2DXS
Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Genome polyprotein | polymer | 552 | 61357.3 | 2 | UniProt (P26663) | Hepatitis C virus | NS5B, p68 |
| 2 | C, D (A, B) | N-[(13-CYCLOHEXYL-6,7-DIHYDROINDOLO[1,2-D][1,4]BENZOXAZEPIN-10-YL)CARBONYL]-2-METHYL-L-ALANINE | non-polymer | 446.5 | 2 | Chemie (JTP) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 584 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 544 (UniProt: P26663)
| PDB | External Database | Details |
|---|---|---|
| Gln 544 | Arg 2962 | SEE REMARK 999 |
| Gly 545 | - | cloning artifact |
| Ser 546 | - | cloning artifact |
| His 547 | - | cloning artifact |
| His 548 | - | cloning artifact |
| Asp 549 | - | cloning artifact |
| His 550 | - | cloning artifact |
| His 551 | - | cloning artifact |
| His 552 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 122714.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 893.1 | |
| All* | Total formula weight | 123607.7 |
