2IJN
Isothiazoles as active-site inhibitors of HCV NS5B polymerase
Summary for 2IJN
Entry DOI | 10.2210/pdb2ijn/pdb |
Related | 2HWH 2HWI 2I1R |
Descriptor | RNA polymerase NS5B, (2R,3R)-3-{[3,5-BIS(TRIFLUOROMETHYL)PHENYL]AMINO}-2-CYANO-3-THIOXOPROPANAMIDE (3 entities in total) |
Functional Keywords | hcv; ns5b; viral rna directed rna polymerase; rdrp; active site; covalent inhibitor, transcription, transferase |
Biological source | Hepatitis C virus subtype 1b |
Total number of polymer chains | 2 |
Total formula weight | 128741.20 |
Authors | |
Primary citation | Yan, S.,Appleby, T.,Gunic, E.,Shim, J.H.,Tasu, T.,Kim, H.,Rong, F.,Chen, H.,Hamatake, R.,Wu, J.Z.,Hong, Z.,Yao, N. Isothiazoles as active-site inhibitors of HCV NS5B polymerase Bioorg.Med.Chem.Lett., 17:28-33, 2007 Cited by PubMed: 17049853DOI: 10.1016/j.bmcl.2006.10.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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