2IJN
Isothiazoles as active-site inhibitors of HCV NS5B polymerase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| B | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 221 A 9366 |
| Chain | Residue |
| A | PHE193 |
| A | MET414 |
| A | TYR415 |
| A | TYR448 |
| A | SER556 |
| A | HOH9439 |
| A | HOH9499 |
| A | ARG200 |
| A | ASN316 |
| A | ASP318 |
| A | ASP319 |
| A | CYS366 |
| A | SER368 |
| A | LEU384 |
| A | ARG386 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 221 B 9366 |
| Chain | Residue |
| B | PHE193 |
| B | ARG200 |
| B | ASN316 |
| B | ASP318 |
| B | ASP319 |
| B | CYS366 |
| B | SER367 |
| B | LEU384 |
| B | ARG386 |
| B | MET414 |
| B | TYR415 |
| B | TYR448 |
| B | SER556 |
| B | HOH9425 |
| B | HOH9434 |
