2J7W

Dengue virus NS5 RNA dependent RNA polymerase domain complexed with 3' dGTP

Summary for 2J7W

DescriptorPOLYPROTEIN, ZINC ION, GUANOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywordsnucleoside binding site, rna-dependent rna polymerase, dengue, flavivirus, high-throughput assay, viral protein
Biological sourceDENGUE VIRUS
Cellular locationEnvelope protein E: Virion membrane; Multi- pass membrane protein Q6DLV0
Total number of polymer chains1
Total molecular weight74356.93
Authors
Yap, T.L.,Xu, T.,Chen, Y.L.,Malet, H.,Egloff, M.P.,Canard, B.,Vasudevan, S.G.,Lescar, J. (deposition date: 2006-10-17, release date: 2007-03-13, Last modification date: 2011-07-13)
Primary citation
Yap, T.L.,Xu, T.,Chen, Y.L.,Malet, H.,Egloff, M.P.,Canard, B.,Vasudevan, S.G.,Lescar, J.
Crystal Structure of the Dengue Virus RNA- Dependent RNA Polymerase Catalytic Domain at 1.85 Angstrom Resolution.
J.Virol., 81:4753-, 2007
PubMed: 17301146 (PDB entries with the same primary citation)
DOI: 10.1128/JVI.02283-06
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.28061.1%4.3%10.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution