PDB: 317 件ウェブページステータス検索Chemie searchBIRD

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7EH0	Thermus thermophilus RNA polymerase transcription initiation complex containing a template-strand purine at position TSS-2, UpA RNA primer and CMPcPP 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (27-MER), DNA (5'-D(*CP*C*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*AP*AP*AP*G)-3'), ... 著者 Li, L, Zhang, Y. 登録日 2021-03-27 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.808 Å) 主引用文献 Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli . Proc.Natl.Acad.Sci.USA, 118, 2021
7EH2	Thermus thermophilus transcription initiation complex containing a template-strand pyrimidine at position TSS-2 and GpG RNA primer 分子名称: DNA (27-MER), DNA (5'-D(*CP*C*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*AP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Li, L, Zhang, Y. 登録日 2021-03-27 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.34 Å) 主引用文献 Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli . Proc.Natl.Acad.Sci.USA, 118, 2021
7EH1	Thermus thermophilus transcription initiation complex containing a template-strand purine at position TSS-2, GpG RNA primer, and CMPcPP 分子名称: 1,4-BUTANEDIOL, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (27-MER), ... 著者 Li, L, Zhang, Y. 登録日 2021-03-27 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli . Proc.Natl.Acad.Sci.USA, 118, 2021
7MKJ	Cryo-EM structure of Escherichia coli RNA polymerase bound to T7A1 promoter DNA 分子名称: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Saecker, R.M, Darst, S.A, Chen, J. 登録日 2021-04-23 公開日 2021-09-29 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKD	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 1) 分子名称: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Saecker, R.M, Darst, S.A, Chen, J. 登録日 2021-04-23 公開日 2021-09-29 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKE	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 2) 分子名称: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Saecker, R.M, Darst, S.A, Chen, J. 登録日 2021-04-23 公開日 2021-09-29 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKI	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR (-5G to C) promoter DNA 分子名称: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Saecker, R.M, Darst, S.A, Chen, J. 登録日 2021-04-23 公開日 2021-09-29 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MLB	Crystal structure of Thermus thermophilus transcription initiation complex with 5nt RNA 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*AP*GP*GP*GP*AP*TP*GP*CP*AP*G)-3'), DNA (5'-D(P*CP*TP*GP*CP*AP*TP*CP*CP*CP*TP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Liu, Y, Ebright, R.H. 登録日 2021-04-28 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7MLI	Crystal structure of Thermus thermophilus reiterative transcription complex with 5nt oligo-C RNA 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*CP*TP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*AP*GP*GP*GP*CP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Liu, Y, Ebright, R.H. 登録日 2021-04-28 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7MLJ	Crystal structure of Thermus thermophilus reiterative transcription complex with 4nt oligo-G RNA 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*GP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*GP*CP*CP*CP*TP*GP*AP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Liu, Y, Ebright, R.H. 登録日 2021-04-28 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.75 Å) 主引用文献 Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7N4E	Escherichia coli sigma 70-dependent paused transcription elongation complex 分子名称: 5'-R(*UP*UP*CP*GP*GP*AP*GP*AP*GP*GP*UP*A)-3', DNA (61-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Molodtsov, V, Su, M, Ebright, R.H. 登録日 2021-06-04 公開日 2022-06-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural and mechanistic basis of sigma-dependent transcriptional pausing. Proc.Natl.Acad.Sci.USA, 119, 2022
7F0R	Cryo-EM structure of Pseudomonas aeruginosa SutA transcription activation complex 分子名称: DNA (70-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 He, D.W, You, L.L, Zhang, Y. 登録日 2021-06-06 公開日 2022-07-27 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (5.8 Å) 主引用文献 Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
7F75	Cryo-EM structure of Spx-dependent transcription activation complex 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Lin, W, Feng, Y, Shi, J. 登録日 2021-06-28 公開日 2021-10-13 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural basis of transcription activation by the global regulator Spx. Nucleic Acids Res., 49, 2021
7RDQ	Cryo-EM structure of Thermus thermophilus reiterative transcription complex with 11nt oligo-G RNA 分子名称: DNA (31-MER) nontemplate strand, DNA (31-MER) template strand, DNA-directed RNA polymerase subunit alpha, ... 著者 Liu, Y, Ebright, R.H. 登録日 2021-07-10 公開日 2022-02-02 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7P5X	Mycobacterial RNAP with transcriptional activator PafBC 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E. 登録日 2021-07-15 公開日 2021-12-22 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Transcriptional control of mycobacterial DNA damage response by sigma adaptation. Sci Adv, 7, 2021
7RWI	Mycobacterium tuberculosis RNA polymerase sigma L holoenzyme open promoter complex containing TNP-2198 分子名称: (3aM,9S,10bP,14S,15R,16S,17R,18R,19R,20S,21S,25R)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]-5,10,26-trioxo-3,5,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl acetate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Molodtsov, V, Ebright, R.H. 登録日 2021-08-19 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. J.Med.Chem., 65, 2022
7VF9	Cryo-EM structure of Pseudomonas aeruginosa RNAP sigmaS holoenzyme complexes 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 He, D.W, You, L.L, Zhang, Y. 登録日 2021-09-10 公開日 2022-07-27 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (4.04 Å) 主引用文献 Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
7PP4	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme comprising sigma factor SigB 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Brodolin, K. 登録日 2021-09-13 公開日 2022-09-21 実験手法 ELECTRON MICROSCOPY (3.84 Å) 主引用文献 Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Biorxiv, 2022
7VPD	Cryo-EM structure of Streptomyces coelicolor RNAP-promoter open complex with one Zur dimers 分子名称: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Yang, X, Zheng, J. 登録日 2021-10-15 公開日 2022-08-03 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.77 Å) 主引用文献 Structural basis of Streptomyces transcription activation by zinc uptake regulator. Nucleic Acids Res., 50, 2022
7VPZ	Cryo-EM structure of Streptomyces coelicolor transcription initial complex with one Zur dimer 分子名称: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Yang, X, Zheng, J. 登録日 2021-10-18 公開日 2022-08-03 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (4.14 Å) 主引用文献 Structural basis of Streptomyces transcription activation by zinc uptake regulator. Nucleic Acids Res., 50, 2022
7Q4U	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme octamer comprising sigma factor SigB 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Brodolin, K. 登録日 2021-11-02 公開日 2022-11-16 最終更新日 2023-02-08 実験手法 ELECTRON MICROSCOPY (4.39 Å) 主引用文献 Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Nat Commun, 14, 2023
7Q59	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme dimer comprising sigma factor SigB 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Brodolin, K. 登録日 2021-11-03 公開日 2022-11-16 最終更新日 2023-02-08 実験手法 ELECTRON MICROSCOPY (4.36 Å) 主引用文献 Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Nat Commun, 14, 2023
7VWZ	Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Lin, W, Feng, Y, Shi, J. 登録日 2021-11-12 公開日 2022-06-08 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator. Nucleic Acids Res., 50, 2022
7VWY	Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Lin, W, Feng, Y. 登録日 2021-11-12 公開日 2022-06-08 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (4.57 Å) 主引用文献 Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator. Nucleic Acids Res., 50, 2022
7SZK	Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex 分子名称: (2S,7R,7aR,13aP,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1,6,15-trioxo-1,2,7,7a-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate, DNA (5'-D(P*CP*TP*CP*GP*TP*AP*GP*AP*GP*TP*CP*CP*GP*TP*GP*TP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Shin, Y, Murakami, K.S. 登録日 2021-11-28 公開日 2022-07-13 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022

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