8G6J
| mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2) | 分子名称: | (3R,6R,9S,12S,15S,18S,20R,24aR)-6-[(2S)-butan-2-yl]-3,12-bis[(1R)-1-hydroxy-2-methylpropyl]-8,9,11,17,18-pentamethyl-15-[(2S)-2-methylbutyl]hexadecahydropyrido[1,2-a][1,4,7,10,13,16,19]heptaazacyclohenicosine-1,4,7,10,13,16,19(21H)-heptone, (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 1,4-DIAMINOBUTANE, ... | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | 登録日 | 2023-02-15 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
|
|
8G6H
| H2BK120ub+H3K79me2-modified nucleosome ubiquitin position 6 | 分子名称: | 601 DNA (185-MER), Histone H2A, Histone H2B 1.1, ... | 著者 | Hicks, C.W, Wolberger, C, Keogh, M. | 登録日 | 2023-02-15 | 公開日 | 2024-02-21 | 最終更新日 | 2024-09-25 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch. Nucleic Acids Res., 52, 2024
|
|
8G60
| mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state) | 分子名称: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | 登録日 | 2023-02-14 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
|
|
8G61
| mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state) | 分子名称: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | 登録日 | 2023-02-14 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
|
|
8G5Y
| mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state) | 分子名称: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | 登録日 | 2023-02-14 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.29 Å) | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
|
|
8ID2
| Crystal structure of the ubiquitin-like domain in the SF3A1 subunit of human U2 snRNP complexed with the stem-loop 4 of U1 snRNA | 分子名称: | RNA (5'-R(*GP*GP*GP*GP*AP*CP*UP*GP*CP*GP*UP*UP*CP*GP*CP*GP*CP*UP*UP*UP*CP*CP*CP*C)-3'), Splicing factor 3A subunit 1 | 著者 | Terawaki, S, Nameki, N, Kuwasako, K. | 登録日 | 2023-02-12 | 公開日 | 2023-05-17 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural insights into recognition of SL4, the UUCG stem-loop, of human U1 snRNA by the ubiquitin-like domain, including the C-terminal tail in the SF3A1 subunit of U2 snRNP. J.Biochem., 174, 2023
|
|
8IC9
| Lys48-linked K48C-diubiquitin | 分子名称: | Polyubiquitin-B, Ubiquitin | 著者 | Hiranyakorn, M, Yagi-Utsumi, M, Yanaka, S, Ohtsuka, N, Momiyama, N, Satoh, T, Kato, K. | 登録日 | 2023-02-11 | 公開日 | 2023-04-26 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Mutational and Environmental Effects on the Dynamic Conformational Distributions of Lys48-Linked Ubiquitin Chains. Int J Mol Sci, 24, 2023
|
|
8CIV
| Translocation intermediate 5 (TI-5) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | 著者 | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | 登録日 | 2023-02-10 | 公開日 | 2023-09-20 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.47 Å) | 主引用文献 | mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024
|
|
8CH6
| Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex). | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | 著者 | Cretu, C, Schmitzova, J, Pena, V. | 登録日 | 2023-02-07 | 公開日 | 2023-05-10 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | Structural basis of catalytic activation in human splicing. Nature, 617, 2023
|
|
8CGN
| Non-rotated 80S S. cerevisiae ribosome with ligands | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | 著者 | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | 登録日 | 2023-02-06 | 公開日 | 2023-09-20 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.28 Å) | 主引用文献 | mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024
|
|
8CG8
| Translocation intermediate 3 (TI-3) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | 著者 | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | 登録日 | 2023-02-03 | 公開日 | 2023-09-20 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | 主引用文献 | mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024
|
|
8G1P
| Co-crystal structure of Compound 11 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | 分子名称: | (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | 著者 | Ghimire Rijal, S, Wurz, R.P, Vaish, A. | 登録日 | 2023-02-02 | 公開日 | 2023-07-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation. Nat Commun, 14, 2023
|
|
8G1Q
| Co-crystal structure of Compound 1 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB | 分子名称: | DI(HYDROXYETHYL)ETHER, Elongin-B, Elongin-C, ... | 著者 | Ghimire Rijal, S, Wurz, R.P, Vaish, A. | 登録日 | 2023-02-02 | 公開日 | 2023-07-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.73 Å) | 主引用文献 | Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation. Nat Commun, 14, 2023
|
|
8CF5
| Translocation intermediate 1 (TI-1) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | 著者 | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | 登録日 | 2023-02-02 | 公開日 | 2023-09-20 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024
|
|
8CEH
| Translocation intermediate 4 (TI-4) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | 著者 | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | 登録日 | 2023-02-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.05 Å) | 主引用文献 | mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024
|
|
8CDL
| 80S S. cerevisiae ribosome with ligands in hybrid-2 pre-translocation (PRE-H2) complex | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | 著者 | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | 登録日 | 2023-01-31 | 公開日 | 2023-09-20 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | 主引用文献 | mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024
|
|
8CDR
| Translocation intermediate 2 (TI-2) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | 著者 | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | 登録日 | 2023-01-31 | 公開日 | 2023-09-20 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.04 Å) | 主引用文献 | mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024
|
|
8I7J
| |
8CCS
| 80S S. cerevisiae ribosome with ligands in hybrid-1 pre-translocation (PRE-H1) complex | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | 著者 | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | 登録日 | 2023-01-27 | 公開日 | 2023-09-20 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (1.97 Å) | 主引用文献 | mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024
|
|
8FY2
| E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2) | 分子名称: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | 著者 | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Ruben, E, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | 登録日 | 2023-01-25 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
|
|
8FY0
| E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL) | 分子名称: | Bcl-2-like protein 1, CACODYLIC ACID, Elongin-B, ... | 著者 | Olsen, S.K, Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D. | 登録日 | 2023-01-25 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
|
|
8FY1
| E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2) | 分子名称: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | 著者 | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | 登録日 | 2023-01-25 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
|
|
8CAF
| N8C_Fab3b in complex with NEDD8-CUL1(WHB) | 分子名称: | Cullin-1, Fab Heavy Chain, Fab Light Chain, ... | 著者 | Duda, D.M, Yanishevski, D, Henneberg, L.T, Schulman, B.A. | 登録日 | 2023-01-24 | 公開日 | 2023-09-13 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | Activity-based profiling of cullin-RING E3 networks by conformation-specific probes. Nat.Chem.Biol., 19, 2023
|
|
8CAS
| Cryo-EM structure of native Otu2-bound ubiquitinated 48S initiation complex (partial) | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | 著者 | Ikeuchi, K, Buschauer, R, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | 登録日 | 2023-01-24 | 公開日 | 2023-05-24 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2. Nat Commun, 14, 2023
|
|
8CAH
| Cryo-EM structure of native Otu2-bound ubiquitinated 43S pre-initiation complex | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | 著者 | Ikeuchi, K, Buschauer, R, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | 登録日 | 2023-01-24 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2. Nat Commun, 14, 2023
|
|