8G1Q

Co-crystal structure of Compound 1 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB

Summary for 8G1Q

• Entry DOI: 10.2210/pdb8g1q/pdb
• Related: 8G1P
• Descriptor: Transcription activator BRG1, Elongin-B, Elongin-C, ... (8 entities in total)
• Functional Keywords: ternary complex, protacs, transcription, gene regulation
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 56767.95

Authors

Ghimire Rijal, S.,Wurz, R.P.,Vaish, A. (deposition date: 2023-02-02, release date: 2023-07-26, Last modification date: 2023-08-30)

• Primary citation: Wurz, R.P.,Rui, H.,Dellamaggiore, K.,Ghimire-Rijal, S.,Choi, K.,Smither, K.,Amegadzie, A.,Chen, N.,Li, X.,Banerjee, A.,Chen, Q.,Mohl, D.,Vaish, A.; Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation.; Nat Commun, 14:4177-4177, 2023; PubMed: 37443112; DOI: 10.1038/s41467-023-39904-5

Experimental method

X-RAY DIFFRACTION (3.73 Å)