8G1P

Co-crystal structure of Compound 11 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB

Summary for 8G1P

Entry DOI	10.2210/pdb8g1p/pdb
Descriptor	Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (7 entities in total)
Functional Keywords	ternary complex, protacs, transcription, gene regulation
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	119455.90
Authors	Ghimire Rijal, S.,Wurz, R.P.,Vaish, A. (deposition date: 2023-02-02, release date: 2023-07-26, Last modification date: 2023-08-30)
Primary citation	Wurz, R.P.,Rui, H.,Dellamaggiore, K.,Ghimire-Rijal, S.,Choi, K.,Smither, K.,Amegadzie, A.,Chen, N.,Li, X.,Banerjee, A.,Chen, Q.,Mohl, D.,Vaish, A. Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation. Nat Commun, 14:4177-4177, 2023 Cited by PubMed: 37443112 DOI: 10.1038/s41467-023-39904-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation