Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8G1P

Co-crystal structure of Compound 11 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000151	cellular_component	ubiquitin ligase complex
A	0001222	molecular_function	transcription corepressor binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006351	biological_process	DNA-templated transcription
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0016567	biological_process	protein ubiquitination
A	0030891	cellular_component	VCB complex
A	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
A	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0065003	biological_process	protein-containing complex assembly
A	0070449	cellular_component	elongin complex
A	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
A	0140958	biological_process	target-directed miRNA degradation
A	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
A	2000104	biological_process	negative regulation of DNA-templated DNA replication
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000151	cellular_component	ubiquitin ligase complex
B	0001222	molecular_function	transcription corepressor binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006351	biological_process	DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0016567	biological_process	protein ubiquitination
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
B	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0070449	cellular_component	elongin complex
B	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
B	0140958	biological_process	target-directed miRNA degradation
B	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
B	2000104	biological_process	negative regulation of DNA-templated DNA replication
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000151	cellular_component	ubiquitin ligase complex
D	0001222	molecular_function	transcription corepressor binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006351	biological_process	DNA-templated transcription
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0016567	biological_process	protein ubiquitination
D	0030891	cellular_component	VCB complex
D	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
D	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0065003	biological_process	protein-containing complex assembly
D	0070449	cellular_component	elongin complex
D	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D	0140958	biological_process	target-directed miRNA degradation
D	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
D	2000104	biological_process	negative regulation of DNA-templated DNA replication
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000151	cellular_component	ubiquitin ligase complex
E	0001222	molecular_function	transcription corepressor binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006351	biological_process	DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0016567	biological_process	protein ubiquitination
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
E	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0070449	cellular_component	elongin complex
E	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
E	0140958	biological_process	target-directed miRNA degradation
E	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
E	2000104	biological_process	negative regulation of DNA-templated DNA replication
G	0006338	biological_process	chromatin remodeling
G	0016586	cellular_component	RSC-type complex
H	0006338	biological_process	chromatin remodeling
H	0016586	cellular_component	RSC-type complex

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SevFiqlpSrkelp..EYYelIrkpVdfkkIkerirnhk..Yrslgdlekdvml.LchNAqtF

Chain	Residue	Details
G	SER1406-PHE1463

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	130
Details	Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	110
Details	Region: {"description":"Involved in binding to CCT complex"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	18
Details	Region: {"description":"Interaction with Elongin BC complex"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39570797","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9E30","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39570797","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9E31","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)