PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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4XHD	STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN WITH COMPOUND-1 分子名称: GLYCEROL, N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-cyclopropylacetamide, Nuclear receptor subfamily 1 group I member 2 著者 Khan, J.A, Camac, D.M. 登録日 2015-01-05 公開日 2015-01-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR. J.Mol.Biol., 427, 2015
3WPP	Acinetobacter sp. Tol 5 AtaA YDD-DALL3 domains in C-terminal stalk fused to GCN4 adaptors (CstalkC1iii) 分子名称: CHLORIDE ION, Trimeric autotransporter adhesin 著者 Koiwai, K, Hartmann, M.D, Yoshimoto, S, Nur 'Izzah, N, Suzuki, A, Linke, D, Lupas, A.N, Hori, K. 登録日 2014-01-15 公開日 2015-03-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.952 Å) 主引用文献 Structural Basis for Toughness and Flexibility in the C-terminal Passenger Domain of an Acinetobacter Trimeric Autotransporter Adhesin. J.Biol.Chem., 291, 2016
1U3Z	Crystal structure of MLAC mutant of dimerisation domain of NF-kB p50 transcription factor 分子名称: Nuclear factor NF-kappa-B p105 subunit 著者 Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M. 登録日 2004-07-23 公開日 2004-08-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding Structure, 12, 2004
3WQA	Acinetobacter sp. Tol 5 AtaA YDD-DALL3 domains in C-terminal stalk fused to GCN4 adaptors (CstalkC1ii) 分子名称: CHLORIDE ION, NICKEL (II) ION, PHOSPHATE ION, ... 著者 Koiwai, K, Hartmann, M.D, Yoshimoto, S, Nur 'Izzah, N, Suzuki, A, Linke, D, Lupas, A.N, Hori, K. 登録日 2014-01-24 公開日 2015-03-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.401 Å) 主引用文献 Structural Basis for Toughness and Flexibility in the C-terminal Passenger Domain of an Acinetobacter Trimeric Autotransporter Adhesin. J.Biol.Chem., 291, 2016
4XLD	Crystal structure of the human PPARg-LBD/rosiglitazone complex obtained by dry co-crystallization and in situ diffraction 分子名称: 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), FORMIC ACID, ... 著者 Delfosse, V, Guichou, J.-F. 登録日 2015-01-13 公開日 2015-08-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
4Y30	Crystal structure of human protein arginine methyltransferase PRMT6 bound to SAH and EPZ020411 分子名称: GLYCEROL, MAGNESIUM ION, N,N'-dimethyl-N-({3-[4-({trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl}oxy)phenyl]-1H-pyrazol-4-yl}methyl)ethane-1,2-diamine, ... 著者 Swinger, K.K, Boriack-Sjodin, P.A. 登録日 2015-02-10 公開日 2015-04-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. Acs Med.Chem.Lett., 6, 2015
6OJN	Comparative Model of SGIV Major Coat Protein (MCP) Trimer Based on Cryo-EM Map 分子名称: Major capsid protein 著者 Pintilie, G, Chen, D.-H, Tran, B.N, Jakana, J, Wu, J, Hew, C.L, Chiu, W. 登録日 2019-04-11 公開日 2019-06-12 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (8.6 Å) 主引用文献 Segmentation and Comparative Modeling in an 8.6- angstrom Cryo-EM Map of the Singapore Grouper Iridovirus. Structure, 27, 2019
4ERZ	X-ray structure of WDR5-MLL4 Win motif peptide binary complex 分子名称: Histone-lysine N-methyltransferase MLL4, WD repeat-containing protein 5 著者 Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S. 登録日 2012-04-21 公開日 2012-05-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. J.Biol.Chem., 287, 2012
6HWU	Crystal structure of p38alpha in complex with a photoswitchable 2-Azothiazol-based Inhibitor (compound 2) 分子名称: 3-(2,5-dimethoxyphenyl)-~{N}-[4-[4-(4-fluorophenyl)-2-[(~{E})-phenyldiazenyl]-1,3-thiazol-5-yl]pyridin-2-yl]propanamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Mueller, M.P, Rauh, D. 登録日 2018-10-15 公開日 2019-04-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach. Photochem. Photobiol. Sci., 18, 2019
3WPR	Acinetobacter sp. Tol 5 AtaA N-terminal half of C-terminal stalk fused to GCN4 adaptors (CstalkN) 分子名称: Trimeric autotransporter adhesin 著者 Koiwai, K, Hartmann, M.D, Yoshimoto, S, Nur 'Izzah, N, Suzuki, A, Linke, D, Lupas, A.N, Hori, K. 登録日 2014-01-15 公開日 2015-03-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.899 Å) 主引用文献 Structural Basis for Toughness and Flexibility in the C-terminal Passenger Domain of an Acinetobacter Trimeric Autotransporter Adhesin. J.Biol.Chem., 291, 2016
3WWT	Crystal Structure of the Y3:STAT1ND complex 分子名称: C' protein, CALCIUM ION, Signal transducer and activator of transcription 1-alpha/beta 著者 Oda, K, Sakaguchi, T, Matoba, Y. 登録日 2014-06-27 公開日 2015-07-01 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein. J.Virol., 89, 2015
7ZJS	Structural basis of centromeric cohesion protection by SGO1 分子名称: Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog, Shugoshin 1 著者 Patel, A, Panne, D. 登録日 2022-04-11 公開日 2023-04-26 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 Structural basis of centromeric cohesion protection. Nat.Struct.Mol.Biol., 30, 2023
4NYC	Crystal structure of the E. coli thiM riboswitch in complex with thieno[2,3-b]pyrazin-7-amine 分子名称: MAGNESIUM ION, MANGANESE (II) ION, thiM TPP riboswitch, ... 著者 Warner, K.D, Homan, P, Weeks, K.M, Smith, A.G, Abell, C, Ferre-D'Amare, A.R. 登録日 2013-12-10 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically. Chem.Biol., 21, 2014
5IXK	RORgamma in complex with inverse agonist BIO399. 分子名称: N-(5-ethyl-3,3-dimethyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-8-yl)-3,4-dimethyl-N-(2,2,2-trifluoroethyl)benzene-1-sulfonamide, Nuclear receptor ROR-gamma 著者 Marcotte, D.J. 登録日 2016-03-23 公開日 2016-06-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand. Bmc Struct.Biol., 16, 2016
6DMP	De Novo Design of a Protein Heterodimer with Specificity Mediated by Hydrogen Bond Networks 分子名称: Designed orthogonal protein DHD13_XAAA_A, Designed orthogonal protein DHD13_XAAA_B 著者 Chen, Z, Flores-Solis, D, Sgourakis, N.G, Baker, D. 登録日 2018-06-05 公開日 2018-12-19 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Programmable design of orthogonal protein heterodimers. Nature, 565, 2019
4ERQ	X-ray structure of WDR5-MLL2 Win motif peptide binary complex 分子名称: Histone-lysine N-methyltransferase MLL2, WD repeat-containing protein 5 著者 Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S. 登録日 2012-04-20 公開日 2012-05-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.906 Å) 主引用文献 Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. J.Biol.Chem., 287, 2012
5KI6	Human Argonaute-2 bound to a guide RNA with a nucleobase modification at position 1 分子名称: PHENOL, Protein argonaute-2, miR-122 著者 Schirle, N.T, MacRae, I.J. 登録日 2016-06-16 公開日 2016-07-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.153 Å) 主引用文献 Structure-Guided Control of siRNA Off-Target Effects. J.Am.Chem.Soc., 138, 2016
5JWQ	Crystal structure of KaiC S431E in complex with foldswitch-stabilized KaiB from Thermosynechococcus elongatus 分子名称: ADENOSINE-5'-DIPHOSPHATE, Circadian clock protein KaiB, Circadian clock protein kinase KaiC 著者 Tseng, R, Goularte, N.F, Chavan, A, Luu, J, Chang, Y, Heilser, J, Tripathi, S, LiWang, A, Partch, C.L. 登録日 2016-05-12 公開日 2017-03-29 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.871 Å) 主引用文献 Structural basis of the day-night transition in a bacterial circadian clock. Science, 355, 2017
5K1A	Crystal structure of the UAF1-USP12 complex in C2 space group 分子名称: Ubiquitin carboxyl-terminal hydrolase 12, WD repeat-containing protein 48, ZINC ION 著者 Li, H, D'Andrea, A.D, Zheng, N. 登録日 2016-05-18 公開日 2016-07-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20. Mol.Cell, 63, 2016
5K3N	Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain complex with ML209 分子名称: (3S)-3-(2H-1,3-benzodioxol-5-yl)-1-[(3R,5S)-3,5-dimethylpiperidin-1-yl]-3-(2-hydroxy-4,6-dimethoxyphenyl)propan-1-one, Nuclear receptor ROR-gamma 著者 Huang, P, Rastinejad, F, Lu, J. 登録日 2016-05-19 公開日 2017-05-31 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.666 Å) 主引用文献 Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain complex with ML209 To be published
4XMN	Structure of the yeast coat nucleoporin complex, space group P212121 分子名称: Antibody 87 heavy chain, Antibody 87 light chain, Nucleoporin NUP120, ... 著者 Stuwe, T, Correia, A.R, Lin, D.H, Paduch, M, Lu, V.T, Kossiakoff, A.A, Hoelz, A. 登録日 2015-01-14 公開日 2015-03-25 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (7.6 Å) 主引用文献 Nuclear pores. Architecture of the nuclear pore complex coat. Science, 347, 2015
4XTA	MECHANISMS OF PPARgamma ACTIVATION BY NON-STEROIDAL ANTI-INFLAMMATORY DRUGS 分子名称: 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, Peroxisome proliferator-activated receptor gamma 著者 Puhl, A.C, Webb, P, Polikarpov, I. 登録日 2015-01-23 公開日 2015-11-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Mechanisms of peroxisome proliferator activated receptor gamma regulation by non-steroidal anti-inflammatory drugs. Nucl Recept Signal, 13, 2015
5K13	Crystal structure of the RAR alpha ligand-binding domain in complex with an antagonist 分子名称: 4-{5-(3-tert-butylphenyl)-1-[4-(methylsulfonyl)phenyl]-1H-pyrazol-3-yl}benzoic acid, Retinoic acid receptor alpha 著者 Wang, Y, Stout, S.L. 登録日 2016-05-17 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Identification of potent and selective retinoic acid receptor gamma (RAR gamma ) antagonists for the treatment of osteoarthritis pain using structure based drug design. Bioorg.Med.Chem.Lett., 26, 2016
4Y2H	Crystal structure of human protein arginine methyltransferase PRMT6 bound to SAH and an aryl pyrazole inhibitor 分子名称: GLYCEROL, N-{[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl}-N-methylethane-1,2-diamine, Protein arginine N-methyltransferase 6, ... 著者 Swinger, K.K, Boriack-Sjodin, P.A. 登録日 2015-02-09 公開日 2015-04-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. Acs Med.Chem.Lett., 6, 2015
6OCX	Structure of human CIB1 in complex with peptide inhibitor UNC10245109 分子名称: CALCIUM ION, Calcium and integrin-binding protein 1, Peptide inhibitor UNC10245109 著者 Puhl, A.C, Godoy, A.S, Pearce, K. 登録日 2019-03-25 公開日 2020-03-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery and Characterization of Peptide Inhibitors for Calcium and Integrin Binding Protein 1. Acs Chem.Biol., 15, 2020

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