Crystal structure of the human PPARg-LBD/rosiglitazone complex obtained by dry co-crystallization and in situ diffraction

Summary for 4XLD

DescriptorPeroxisome proliferator-activated receptor gamma, FORMIC ACID, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), ... (4 entities in total)
Functional Keywordsnuclear receptor ligand screening, gene regulation
Biological sourceHomo sapiens (Human)
Cellular locationNucleus P37231
Total number of polymer chains1
Total molecular weight34155.52
Delfosse, V.,Guichou, J.-F. (deposition date: 2015-01-13, release date: 2015-08-12, Last modification date: 2015-08-19)
Primary citation
Gelin, M.,Delfosse, V.,Allemand, F.,Hoh, F.,Sallaz-Damaz, Y.,Pirocchi, M.,Bourguet, W.,Ferrer, J.L.,Labesse, G.,Guichou, J.F.
Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
Acta Crystallogr.,Sect.D, 71:1777-1787, 2015
PubMed: 26249358 (PDB entries with the same primary citation)
DOI: 10.1107/S1399004715010342
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22430.4%00.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report