4XLD

Crystal structure of the human PPARg-LBD/rosiglitazone complex obtained by dry co-crystallization and in situ diffraction

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Peroxisome proliferator-activated receptor gamma	polymer	296	33752.1	1	UniProt (P37231) Pfam (PF00104)	Homo sapiens (Human)	PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
2	B (A)	FORMIC ACID	non-polymer		46.0	1	Chemie (FMT)
3	C (A)	2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL)	non-polymer		357.4	1	Chemie (BRL)
4	D (A)	water	water		18.0	25	Chemie (HOH)

Sequence modifications

A: 203 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 182	-	initiating methionine
Gly 183	-	expression tag
Ser 184	-	expression tag
Ser 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
His 188	-	expression tag
His 189	-	expression tag
His 190	-	expression tag
His 191	-	expression tag
Ser 192	-	expression tag
Ser 193	-	expression tag
Gly 194	-	expression tag
Leu 195	-	expression tag
Val 196	-	expression tag
Pro 197	-	expression tag
Arg 198	-	expression tag
Gly 199	-	expression tag
Ser 200	-	expression tag
His 201	-	expression tag
Met 202	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33752.1
Non-Polymers*	Number of molecules	2
	Total formula weight	403.5
All*	Total formula weight	34155.5

*Water molecules are not included.