4XLD

Crystal structure of the human PPARg-LBD/rosiglitazone complex obtained by dry co-crystallization and in situ diffraction

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue BRL A 502

Chain	Residue
A	PHE282
A	TYR473
A	HOH620
A	CYS285
A	SER289
A	HIS323
A	TYR327
A	ILE341
A	PHE363
A	MET364
A	HIS449

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG

Chain	Residue	Details
A	GLN314
A	GLU351
A	TYR477

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649

Chain	Residue	Details
A	MET252

---