4Y2H

Crystal structure of human protein arginine methyltransferase PRMT6 bound to SAH and an aryl pyrazole inhibitor

Summary for 4Y2H

Entry DOI	10.2210/pdb4y2h/pdb
Related	4Y30
Descriptor	Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, N-{[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl}-N-methylethane-1,2-diamine, ... (5 entities in total)
Functional Keywords	transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q96LA8
Total number of polymer chains	2
Total formula weight	80607.50
Authors	Swinger, K.K.,Boriack-Sjodin, P.A. (deposition date: 2015-02-09, release date: 2015-04-22, Last modification date: 2024-02-28)
Primary citation	Mitchell, L.H.,Drew, A.E.,Ribich, S.A.,Rioux, N.,Swinger, K.K.,Jacques, S.L.,Lingaraj, T.,Boriack-Sjodin, P.A.,Waters, N.J.,Wigle, T.J.,Moradei, O.,Jin, L.,Riera, T.,Porter-Scott, M.,Moyer, M.P.,Smith, J.J.,Chesworth, R.,Copeland, R.A. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. Acs Med.Chem.Lett., 6:655-659, 2015 Cited by PubMed: 26101569 DOI: 10.1021/acsmedchemlett.5b00071 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation