4Y2H

Crystal structure of human protein arginine methyltransferase PRMT6 bound to SAH and an aryl pyrazole inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Protein arginine N-methyltransferase 6	polymer	352	39625.0	2	UniProt (Q96LA8) Pfam (PF13649) Pfam (PF22528)	Homo sapiens (Human)	Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6,Histone-arginine N-methyltransferase PRMT6
2	C, E (A, B)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH) PubChem (16760024) PubChem (25210495) PubChem (177678424) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (44361184) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (6419189) PubChem (52224398) PubChem (57544532) PubChem (164157219) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (126969526) PubChem (71170554) PubChem (129105892) PubChem (13231890) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
3	D, F (A, B)	N-{[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl}-N-methylethane-1,2-diamine	non-polymer		248.3	2	Chemie (49K)
4	G (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
5	H, I (A, B)	water	water		18.0	262	Chemie (HOH)

Sequence modifications

A, B: 27 - 375 (UniProt: Q96LA8)

PDB	External Database	Details
Ser 24	-	expression tag
Ile 25	-	expression tag
Ala 26	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	79250.0
Non-Polymers*	Number of molecules	5
	Total formula weight	1357.5
All*	Total formula weight	80607.5

*Water molecules are not included.