4Y2H
Crystal structure of human protein arginine methyltransferase PRMT6 bound to SAH and an aryl pyrazole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protein arginine N-methyltransferase 6 | polymer | 352 | 39625.0 | 2 | UniProt (Q96LA8) Pfam (PF13649) Pfam (PF22528) | Homo sapiens (Human) | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6,Histone-arginine N-methyltransferase PRMT6 |
| 2 | C, E (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 3 | D, F (A, B) | N-{[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl}-N-methylethane-1,2-diamine | non-polymer | 248.3 | 2 | Chemie (49K) | |||
| 4 | G (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 262 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 375 (UniProt: Q96LA8)
| PDB | External Database | Details |
|---|---|---|
| Ser 24 | - | expression tag |
| Ile 25 | - | expression tag |
| Ala 26 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79250.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1357.5 | |
| All* | Total formula weight | 80607.5 |
