4Y30

Crystal structure of human protein arginine methyltransferase PRMT6 bound to SAH and EPZ020411

Summary for 4Y30

• Entry DOI: 10.2210/pdb4y30/pdb
• Related: 4Y2H
• Descriptor: Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, N,N'-dimethyl-N-({3-[4-({trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl}oxy)phenyl]-1H-pyrazol-4-yl}methyl)ethane-1,2-diamine, ... (6 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q96LA8
• Total number of polymer chains: 2
• Total formula weight: 81004.27

Authors

Swinger, K.K.,Boriack-Sjodin, P.A. (deposition date: 2015-02-10, release date: 2015-04-22, Last modification date: 2024-02-28)

• Primary citation: Mitchell, L.H.,Drew, A.E.,Ribich, S.A.,Rioux, N.,Swinger, K.K.,Jacques, S.L.,Lingaraj, T.,Boriack-Sjodin, P.A.,Waters, N.J.,Wigle, T.J.,Moradei, O.,Jin, L.,Riera, T.,Porter-Scott, M.,Moyer, M.P.,Smith, J.J.,Chesworth, R.,Copeland, R.A.; Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.; Acs Med.Chem.Lett., 6:655-659, 2015; PubMed: 26101569; DOI: 10.1021/acsmedchemlett.5b00071

Experimental method

X-RAY DIFFRACTION (2.1 Å)