4Y30

Crystal structure of human protein arginine methyltransferase PRMT6 bound to SAH and EPZ020411

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Protein arginine N-methyltransferase 6	polymer	351	39524.8	2	UniProt (Q96LA8) Pfam (PF13649) Pfam (PF22528)	Homo sapiens (Human)	Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6,Histone-arginine N-methyltransferase PRMT6
2	C, H (A, B)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (177678424) PubChem (52224398) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (6419189) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (164157219) PubChem (118374891) PubChem (118560068) PubChem (5284331) PubChem (126969526) PubChem (129105892) PubChem (71170554) PubChem (143518505) PubChem (154578335) PubChem (13231890) PubChem (163054214) PubChem (163335525)
3	D, I (A, B)	N,N'-dimethyl-N-({3-[4-({trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl}oxy)phenyl]-1H-pyrazol-4-yl}methyl)ethane-1,2-diamine	non-polymer		442.6	2	Chemie (49L)
4	E (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG) PubChem (888)
5	F, G, J (A, B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL) PubChem (753)
6	K, L (A, B)	water	water		18.0	514	Chemie (HOH)

Sequence modifications

A, B: 25 - 375 (UniProt: Q96LA8)

PDB	External Database	Details
Gln 268	Glu 268	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	79049.7
Non-Polymers*	Number of molecules	8
	Total formula weight	1954.6
All*	Total formula weight	81004.3

*Water molecules are not included.