4Y30
Crystal structure of human protein arginine methyltransferase PRMT6 bound to SAH and EPZ020411
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protein arginine N-methyltransferase 6 | polymer | 351 | 39524.8 | 2 | UniProt (Q96LA8) Pfam (PF13649) Pfam (PF22528) | Homo sapiens (Human) | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6,Histone-arginine N-methyltransferase PRMT6 |
| 2 | C, H (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 3 | D, I (A, B) | N,N'-dimethyl-N-({3-[4-({trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl}oxy)phenyl]-1H-pyrazol-4-yl}methyl)ethane-1,2-diamine | non-polymer | 442.6 | 2 | Chemie (49L) | |||
| 4 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | F, G, J (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 514 | Chemie (HOH) |
Sequence modifications
A, B: 25 - 375 (UniProt: Q96LA8)
| PDB | External Database | Details |
|---|---|---|
| Gln 268 | Glu 268 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79049.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1954.6 | |
| All* | Total formula weight | 81004.3 |
