PDB: 1406 件ウェブページステータス検索Chemie searchBIRD

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5FEB	Crystal structure of the Voltage-gated Sodium Channel Beta 2 subunit extracellular domain 分子名称: GLYCEROL, Sodium channel subunit beta-2 著者 Das, S, Van Petegem, F. 登録日 2015-12-16 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Binary architecture of the Nav1.2-beta 2 signaling complex. Elife, 5, 2016
5GGS	PD-1 in complex with pembrolizumab Fab 分子名称: Programmed cell death protein 1, heavy chain, light chain 著者 Heo, Y.S. 登録日 2016-06-16 公開日 2016-11-09 最終更新日 2016-11-16 実験手法 X-RAY DIFFRACTION (1.997 Å) 主引用文献 Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy Nat Commun, 7, 2016
5FFL	Crystal structure of mouse CD300lf at 1.6 Angstroms resolution. 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CD300 antigen-like family member F, ... 著者 Nelson, C.A, Fremont, D.H. 登録日 2015-12-18 公開日 2016-08-31 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.602 Å) 主引用文献 Discovery of a proteinaceous cellular receptor for a norovirus. Science, 353, 2016
5GGV	CTLA-4 in complex with tremelimumab Fab 分子名称: Cytotoxic T-lymphocyte protein 4, heavy chain, light chain 著者 Heo, Y.S. 登録日 2016-06-16 公開日 2016-11-09 最終更新日 2016-11-16 実験手法 X-RAY DIFFRACTION (1.998 Å) 主引用文献 Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy Nat Commun, 7, 2016
5EDX	Crystal structure of swine CD8aa homodimer 分子名称: CD8 alpha antigen 著者 Liu, Y.J, Qi, J.X, Zhang, N.Z, Xia, C. 登録日 2015-10-22 公開日 2016-09-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 The structural basis of chicken, swine and bovine CD8 alpha alpha dimers provides insight into the co-evolution with MHC I in endotherm species. Sci Rep, 6, 2016
5GGT	PD-L1 in complex with BMS-936559 Fab 分子名称: IGK@ protein, IgG H chain, Programmed cell death 1 ligand 1 著者 Heo, Y.S. 登録日 2016-06-16 公開日 2016-11-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy Nat Commun, 7, 2016
5DZO	Crystal structure of human T-cell immunoglobulin and mucin domain protein 1 分子名称: Hepatitis A virus cellular receptor 1, NITRATE ION, SODIUM ION 著者 Yuan, S, Rao, Z, Wang, X. 登録日 2015-09-25 公開日 2015-11-25 最終更新日 2016-02-10 実験手法 X-RAY DIFFRACTION (1.301 Å) 主引用文献 TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope. Protein Cell, 6, 2015
5F7H	Human T-cell immunoglobulin and mucin domain protein 4 (hTIM-4) complex with phosphoserine 分子名称: CALCIUM ION, PHOSPHOSERINE, T-cell immunoglobulin and mucin domain-containing protein 4 著者 Gao, G.F, Lu, G, Wang, H, Qi, J. 登録日 2015-12-08 公開日 2016-02-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structures of human TIM members: Ebolavirus entry-enhancing receptors Chin.Sci.Bull., 60, 2015
5DZN	human T-cell immunoglobulin and mucin domain protein 4 分子名称: T-cell immunoglobulin and mucin domain-containing protein 4 著者 Yuan, S, Rao, Z, Wang, X. 登録日 2015-09-25 公開日 2015-11-25 最終更新日 2016-02-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope. Protein Cell, 6, 2015
5DZL	Crystal structure of the protein human CEACAM1 分子名称: Carcinoembryonic antigen-related cell adhesion molecule 1 著者 Huang, Y.H, Russell, A, Gandhi, A.K, Kondo, Y, Chen, Q, Petsko, G.A, Blumberg, R.S. 登録日 2015-09-25 公開日 2015-10-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.4006 Å) 主引用文献 CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature, 517, 2015
5E56	Crystal structure of mouse CTLA-4 分子名称: Cytotoxic T-lymphocyte protein 4, SODIUM ION 著者 Fedorov, A.A, Fedorov, E.V, SAMANTA, D, Bonanno, J.B, Almo, S.C. 登録日 2015-10-07 公開日 2015-10-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.504 Å) 主引用文献 Crystal structure of mouse CTLA-4 To Be Published
5EB9	Crystal Structure Of Chicken CD8aa Homodimer 分子名称: CD8 alpha chain 著者 Liu, Y.J, Qi, J.X, Xia, C. 登録日 2015-10-18 公開日 2016-09-14 実験手法 X-RAY DIFFRACTION (2.006 Å) 主引用文献 The structural basis of chicken, swine and bovine CD8 alpha alpha dimers provides insight into the co-evolution with MHC I in endotherm species. Sci Rep, 6, 2016
5GGR	PD-1 in complex with nivolumab Fab 分子名称: Programmed cell death protein 1, heavy chain, light chain 著者 Heo, Y.S. 登録日 2016-06-16 公開日 2016-11-09 最終更新日 2016-11-16 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy Nat Commun, 7, 2016
5B21	Dimer structure of murine Nectin-1 D1 分子名称: murine Nectin-1 D1 著者 Sangawa, T, Takebe, K, Suzuki, M. 登録日 2015-12-28 公開日 2016-12-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Dimer structure of murine Nectin-1 D1 To Be Published
7CZD	Crystal structure of PD-L1 in complex with a VHH 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Programmed cell death 1 ligand 1, ... 著者 Wang, C. 登録日 2020-09-08 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer. J Immunother Cancer, 9, 2021
5A2K	Crystal structure of scFv-SM3 in complex with APD-TGalNAc-RP 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-galactopyranose, ANTIGEN TN, ... 著者 Martinez-Saez, N, Castro-Lopez, J, Valero-Gonzalez, J, Madariaga, D, Companon, I, Somovilla, V.J, Salvado, M, Asensio, J.L, Jimenez-Barbero, J, Avenoza, A, Busto, J.H, Bernardes, G.J.L, Peregrina, J.M, Hurtado-Guerrero, R, Corzana, F. 登録日 2015-05-20 公開日 2015-06-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an Anti-Muc1 Antibody. Angew.Chem.Int.Ed.Engl., 54, 2015
5A2J	Crystal structure of scFv-SM3 in complex with the naked peptide APDTRP 分子名称: 1,2-ETHANEDIOL, SCFV-SM3, THE NAKED PEPTIDE APDTRP 著者 Martinez-Saez, N, Castro-Lopez, J, Valero-Gonzalez, J, Madariaga, D, Companon, I, Somovilla, V.J, Salvado, M, Asensio, J.L, Jimenez-Barbero, J, Avenoza, A, Busto, J.H, Bernardes, G.J.L, Peregrina, J.M, Hurtado-Guerrero, R, Corzana, F. 登録日 2015-05-20 公開日 2015-06-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an Anti-Muc1 Antibody. Angew.Chem.Int.Ed.Engl., 54, 2015
7DY7	Discovery of Novel Small-molecule Inhibitors of PD-1/PD-L1 Axis that Promotes PD-L1 Internalization and Degradation 分子名称: 2-[[3-[[5-(2-methyl-3-phenyl-phenyl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methylamino]ethanol, Programmed cell death 1 ligand 1 著者 Cheng, Y, Wang, T.Y, Lu, M.L, Jiang, S, Xiao, Y.B. 登録日 2021-01-20 公開日 2022-01-26 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J.Med.Chem., 65, 2022
5C9K	Crystal structure of a highly fibrillogenic Arg24Gly mutant of the Recombinant variable domain 6AJL2 分子名称: ACETATE ION, Amyloid lambda 6 light chain variable region PIP 著者 Hernandez-Santoyo, A, Rodriguez-Romero, A, Luna-Martinez, O.D, Becerril-Lujan, B. 登録日 2015-06-27 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Mutating amyloidogenic lambda6 light chain AR back to germline 6aJL2 To Be Published
5C2B	anti-CXCL13 parental scFv - 3B4 分子名称: CHLORIDE ION, scFv 3B4 著者 Tu, C, Bard, J, Mosyak, L. 登録日 2015-06-15 公開日 2015-11-04 最終更新日 2020-06-17 実験手法 X-RAY DIFFRACTION (1.4049 Å) 主引用文献 Optimization of a scFv-based biotherapeutic by CDR side-chain clash repair To Be Published
5C6W	anti-CXCL13 scFv - E10 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Tu, C, Bard, J, Mosyak, L. 登録日 2015-06-23 公開日 2015-11-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Optimization of a scFv-based biotherapeutic by CDR side-chain clash repair To Be Published
7BEA	Structure of human Programmed cell death 1 ligand 1 (PD-L1) with inhibitor 分子名称: 2-(aminomethyl)-6-[(2-methyl-3-phenyl-phenyl)methoxy]-~{N}-(2-phenylethyl)imidazo[1,2-a]pyridin-3-amine, Programmed cell death 1 ligand 1 著者 Magiera-Mularz, K, Butera, R, Wazynska, M, Holak, T, Domling, A. 登録日 2020-12-22 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists. Acs Med.Chem.Lett., 12, 2021
4ZQK	Structure of the complex of human programmed death-1 (PD-1) and its ligand PD-L1. 分子名称: Programmed cell death 1 ligand 1, Programmed cell death protein 1, SODIUM ION 著者 Zak, K.M, Dubin, G, Holak, T.A. 登録日 2015-05-10 公開日 2015-11-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1. Structure, 23, 2015
5A2L	Crystal structure of scFv-SM3 in complex with APD-CGalNAc-RP 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-galactopyranose, MODIFIED ANTIGEN TN, ... 著者 Martinez-Saez, N, Castro-Lopez, J, Valero-Gonzalez, J, Madariaga, D, Companon, I, Somovilla, V.J, Salvado, M, Asensio, J.L, Jimenez-Barbero, J, Avenoza, A, Busto, J.H, Bernardes, G.J.L, Peregrina, J.M, Hurtado-Guerrero, R, Corzana, F. 登録日 2015-05-20 公開日 2015-06-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an Anti-Muc1 Antibody. Angew.Chem.Int.Ed.Engl., 54, 2015
7DV4	Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4 分子名称: 1,2-ETHANEDIOL, 4003-1(VH), Cytotoxic T-lymphocyte protein 4 著者 Li, H, Gan, X, He, Y. 登録日 2021-01-12 公開日 2022-01-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 An anti-CTLA-4 heavy chain-only antibody with enhanced T reg depletion shows excellent preclinical efficacy and safety profile. Proc.Natl.Acad.Sci.USA, 119, 2022

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