PDB: 729 件ウェブページステータス検索Chemie searchBIRD

---

3QCM	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]-4-{[3-({N-[2-(methylamino)ethyl]glycyl}amino)phenyl]ethynyl}benzoic acid 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[(3,4-dichlorobenzyl)sulfanyl]-4-{[3-({N-[2-(methylamino)ethyl]glycyl}amino)phenyl]ethynyl}benzoic acid, Receptor-type tyrosine-protein phosphatase gamma 著者 Sheriff, S. 登録日 2011-01-16 公開日 2011-12-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCK	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]benzoic acid 分子名称: 2-[(3,4-dichlorobenzyl)sulfanyl]benzoic acid, Receptor-type tyrosine-protein phosphatase gamma 著者 Sheriff, S. 登録日 2011-01-16 公開日 2011-12-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCI	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with N-[(3-aminophenyl)sulfonyl]-3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxamide 分子名称: N-[(3-aminophenyl)sulfonyl]-3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxamide, Receptor-type tyrosine-protein phosphatase gamma 著者 Sheriff, S. 登録日 2011-01-16 公開日 2011-12-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCD	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, trigonal crystal form 分子名称: ACETIC ACID, Receptor-type tyrosine-protein phosphatase gamma, VANADATE ION 著者 Sheriff, S. 登録日 2011-01-16 公開日 2011-12-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCJ	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 5-[({3-[(3,4-dichlorobenzyl)sulfanyl]thiophen-2-yl}carbonyl)sulfamoyl]-2-methoxybenzoic acid 分子名称: 5-[({3-[(3,4-dichlorobenzyl)sulfanyl]thiophen-2-yl}carbonyl)sulfamoyl]-2-methoxybenzoic acid, Receptor-type tyrosine-protein phosphatase gamma 著者 Sheriff, S. 登録日 2011-01-16 公開日 2011-12-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCB	Human receptor protein tyrosine phosphatase gamma, domain 1, apo 分子名称: Receptor-type tyrosine-protein phosphatase gamma, SULFATE ION 著者 Sheriff, S. 登録日 2011-01-16 公開日 2011-12-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCN	Human receptor protein tyrosine phosphatase gamma, domain 1, trigonal crystal form 分子名称: Receptor-type tyrosine-protein phosphatase gamma 著者 Sheriff, S. 登録日 2011-01-16 公開日 2011-12-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QKQ	Protein Tyrosine Phosphatase 1B - W179F mutant bound with vanadate 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... 著者 Brandao, T.A.S, Johnson, S.J, Hengge, A.C. 登録日 2011-02-01 公開日 2012-08-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch.Biochem.Biophys., 525, 2012
3QKP	Protein Tyrosine Phosphatase 1B - Apo W179F mutant with open WPD-loop 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1 著者 Brandao, T.A.S, Johnson, S.J, Hengge, A.C. 登録日 2011-02-01 公開日 2012-08-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch.Biochem.Biophys., 525, 2012
2YDU	Crystal structure of YopH in complex with 3-(1,1-dioxido-3- oxoisothiazolidin-5-yl)benzaldeyde 分子名称: 3-[(2S)-1,1-DIOXIDO-4-OXOTETRAHYDROTHIOPHEN-2-YL]BENZALDEHYDE, OUTER PROTEIN H PHOSPHATASE 著者 Lountos, G.T, Kim, S.E, Bahta, M, Ulrich, R.G, Waugh, D.S, Burke, T.R. 登録日 2011-03-24 公開日 2011-11-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Isothiazolidinone (Izd) as a Phosphoryl Mimetic in Inhibitors of the Yersinia Pestis Protein Tyrosine Phosphatase Yoph. Acta Crystallogr.,Sect.D, 67, 2011
3RO1	Crystal structure of the complex of the archaeal sulfolobus PTP-fold phosphatase with terpyridine platinum(II) 分子名称: 2,2':6',2''-TERPYRIDINE PLATINUM(II) Chloride, protein tyrosine phosphatase 著者 Lo, Y.-C, Wang, A.H.-J. 登録日 2011-04-25 公開日 2011-10-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Terpyridine platinum(II) complexes inhibit cysteine proteases by binding to active-site cysteine. J.Biomol.Struct.Dyn., 29, 2011
3S3H	Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a phosphopeptide substrate GP4 分子名称: 1,4-BUTANEDIOL, 1-BUTANOL, Tyrosine-protein phosphatase 10D, ... 著者 Madan, L.L, Gopal, B. 登録日 2011-05-18 公開日 2011-11-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3S3F	Crystal Structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecule inhibitor Vanadate 分子名称: 1,4-BUTANEDIOL, 1-BUTANOL, ISOPROPYL ALCOHOL, ... 著者 Madan, L.L, Gopal, B. 登録日 2011-05-18 公開日 2011-11-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3S3K	Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecular inhibitor para-NitroCatechol Sulphate 分子名称: N,4-DIHYDROXY-N-OXO-3-(SULFOOXY)BENZENAMINIUM, Tyrosine-protein phosphatase 10D 著者 Madan, L.L, Gopal, B. 登録日 2011-05-18 公開日 2011-11-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3S3E	Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster 分子名称: 1,4-BUTANEDIOL, 1-BUTANOL, ISOPROPYL ALCOHOL, ... 著者 Madan, L.L, Gopal, B. 登録日 2011-05-18 公開日 2011-11-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3S4O	Protein Tyrosine Phosphatase (putative) from Leishmania major 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Protein tyrosine phosphatase-like protein, THIOSULFATE 著者 Merritt, E.A, Arakaki, T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP), Structural Genomics of Pathogenic Protozoa Consortium (SGPP) 登録日 2011-05-19 公開日 2011-06-15 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Protein Tyrosine Phosphatase from Leishmania major To be Published
3SME	Structure of PTP1B inactivated by H2O2/bicarbonate 分子名称: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 著者 Tanner, J.J, Singh, H. 登録日 2011-06-27 公開日 2011-10-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The Biological Buffer Bicarbonate/CO(2) Potentiates H(2)O(2)-Mediated Inactivation of Protein Tyrosine Phosphatases. J.Am.Chem.Soc., 133, 2011
3SR9	Crystal structure of mouse PTPsigma 分子名称: Receptor-type tyrosine-protein phosphatase S 著者 Wang, J, Hou, L, Li, J, Ding, J. 登録日 2011-07-07 公開日 2012-05-30 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma Acta Biochim.Biophys.Sin., 43, 2011
3ZV2	Human protein-tyrosine phosphatase 1b C215A, S216A mutant 分子名称: Tyrosine-protein phosphatase non-receptor type 1 著者 Barford, D, Salmeen, A, Tonks, N.K. 登録日 2011-07-22 公開日 2011-08-31 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity. Cell, 147, 2011
3U96	Crystal Structure of YopHQ357F(Catalytic Domain, Residues 163-468) in complex with pNCS 分子名称: N,4-DIHYDROXY-N-OXO-3-(SULFOOXY)BENZENAMINIUM, SULFATE ION, Tyrosine-protein phosphatase yopH 著者 Ho, M.C, Ke, S. 登録日 2011-10-17 公開日 2012-08-29 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Investigation of catalytic loop structure, dynamics, and function relationship of Yersinia protein tyrosine phosphatase by temperature-jump relaxation spectroscopy and X-ray structural determination. J.Phys.Chem.B, 116, 2012
4DGP	The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2) 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. 登録日 2012-01-26 公開日 2013-03-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013
4DGX	LEOPARD Syndrome-Associated SHP2/Y279C mutant 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. 登録日 2012-01-27 公開日 2013-03-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013
4AZ1	Crystal structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas' disease 分子名称: 1,2-ETHANEDIOL, FORMIC ACID, TYROSINE SPECIFIC PROTEIN PHOSPHATASE 著者 Lountos, G.T, Tropea, J.E, Waugh, D.S. 登録日 2012-06-22 公開日 2012-11-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.181 Å) 主引用文献 Structure of the Trypanosoma Cruzi Protein Tyrosine Phosphatase Tcptp1, a Potential Therapeutic Target for Chagas' Disease. Mol.Biochem.Parasitol., 187, 2012
4GE2	Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 3 分子名称: N-acetyl-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9 著者 Zhang, Z.-Y, Liu, S, Zhang, S. 登録日 2012-08-01 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012
4GE5	Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 5 分子名称: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9 著者 Zhang, Z.-Y, Liu, S, Zhang, S. 登録日 2012-08-01 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012

<3456789101112131415161718>