PDB: 594 件ウェブページステータス検索Chemie searchBIRD

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3K2M	Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex 分子名称: Monobody HA4, PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase ABL1 著者 Wojcik, J.B, Duguid, E. 登録日 2009-09-30 公開日 2010-03-31 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat.Struct.Mol.Biol., 17, 2010
3MAZ	Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide 分子名称: CheD family protein, MALONATE ION, Signal-transducing adaptor protein 1 著者 Kaneko, T, Huang, H, Zhao, B, Li, L, Liu, H, Voss, C.K, Wu, C, Schiller, M.R, Li, S.S. 登録日 2010-03-24 公開日 2010-05-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Loops govern SH2 domain specificity by controlling access to binding pockets. Sci.Signal., 3, 2010
3NHN	Crystal structure of the SRC-family kinase HCK SH3-SH2-linker regulatory region 分子名称: Tyrosine-protein kinase HCK 著者 Alvarado, J.J, Betts, L, Moroco, J.A, Smithgall, T.E, Yeh, J.I. 登録日 2010-06-14 公開日 2010-09-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism. J.Biol.Chem., 285, 2010
2KNO	NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1) 分子名称: Tensin-like C1 domain-containing phosphatase 著者 Chen, L, Feng, R, Liu, C, Zhu, G. 登録日 2009-08-27 公開日 2010-09-01 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1) To be Published
3M7F	Crystal structure of the Nedd4 C2/Grb10 SH2 complex 分子名称: E3 ubiquitin-protein ligase NEDD4, Growth factor receptor-bound protein 10 著者 Huang, Q, Szebenyi, M. 登録日 2010-03-16 公開日 2010-10-27 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4. J.Biol.Chem., 285, 2010
2L4K	Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139 分子名称: Growth factor receptor-bound protein 7, Receptor tyrosine-protein kinase erbB-2 著者 Pias, S.C, Ivancic, M, Brescia, P.J, Johnson, D.L, Smith, D.E, Daly, R.J, Lyons, B.A. 登録日 2010-10-07 公開日 2010-11-17 最終更新日 2012-10-03 実験手法 SOLUTION NMR 主引用文献 Water-Refined Solution Structure of the Human Grb7-SH2 Domain in Complex with the erbB2 Receptor Peptide pY1139. Protein Pept.Lett., 19, 2012
3N8M	Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP 分子名称: GLYCEROL, Growth factor receptor-bound protein 2, PEPTIDE 著者 Whiddon, B.B, Clements, J.H, Martin, S.F. 登録日 2010-05-28 公開日 2010-12-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3N7Y	Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV 分子名称: 20-membered peptide-like macrocyclic ligand, Growth factor receptor-bound protein 2 著者 Whiddon, B.B, Clements, J.H, Martin, S.F. 登録日 2010-05-27 公開日 2011-01-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3N84	Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP 分子名称: 23-membered peptide-like macrocyclic ligand, CHLORIDE ION, GLYCEROL, ... 著者 Clements, J.H, Martin, S.F. 登録日 2010-05-27 公開日 2011-01-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
2Y3A	Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941 分子名称: 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM 著者 Zhang, X, Vadas, O, Perisic, O, Williams, R.L. 登録日 2010-12-20 公開日 2011-03-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism. Mol.Cell, 41, 2011
3PSI	Crystal Structure of the Spt6 core domain from Saccharomyces cerevisiae, Form Spt6(239-1451) 分子名称: Transcription elongation factor SPT6 著者 Close, D, Hill, C.P, Johnson, S.J. 登録日 2010-12-01 公開日 2011-03-30 最終更新日 2011-08-03 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3PSJ	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Se-Spt6 (1247-1451) 分子名称: SULFATE ION, Transcription elongation factor SPT6 著者 Close, D, Hill, C.P. 登録日 2010-12-01 公開日 2011-03-30 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.702 Å) 主引用文献 Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3PSK	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Native Spt6 (1247-1451) 分子名称: SULFATE ION, Transcription elongation factor SPT6 著者 Close, D, Hill, C.P. 登録日 2010-12-01 公開日 2011-03-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3PS5	Crystal structure of the full-length Human Protein Tyrosine Phosphatase SHP-1 分子名称: SULFATE ION, Tyrosine-protein phosphatase non-receptor type 6 著者 Wang, W, Liu, L, Song, X, Mo, Y, Komma, C, Bellamy, H.D, Zhao, Z.J, Zhou, G.W. 登録日 2010-11-30 公開日 2011-04-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation. J.Cell.Biochem., 112, 2011
3MXC	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. 分子名称: AICD peptide, Growth factor receptor-bound protein 2 著者 Sen, U, Das, S. 登録日 2010-05-07 公開日 2011-05-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
3MXY	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. 分子名称: AICD peptide E683V variant, Growth factor receptor-bound protein 2 著者 Sen, U, Das, S. 登録日 2010-05-08 公開日 2011-05-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
2LCT	Solution structure of the Vav1 SH2 domain complexed with a Syk-derived doubly phosphorylated peptide 分子名称: Proto-oncogene vav, Tyrosine-protein kinase SYK 著者 Chen, C, Gorenstein, N, Post, C. 登録日 2011-05-09 公開日 2011-06-01 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav. Mol.Cell.Biol., 31, 2011
3QWX	CED-2 1-174 分子名称: Cell death abnormality protein 2, SULFATE ION 著者 Kang, Y, Sun, J, Liu, Y. 登録日 2011-02-28 公開日 2011-06-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem.Biophys.Res.Commun., 410, 2011
3QWY	CED-2 分子名称: Cell death abnormality protein 2, GLYCEROL, SULFATE ION 著者 Kang, Y, Sun, J, Liu, Y, Sun, D, Hu, Y, Liu, Y.F. 登録日 2011-02-28 公開日 2011-06-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem.Biophys.Res.Commun., 410, 2011
2L3T	Solution structure of tandem SH2 domain from Spt6 分子名称: Transcription elongation factor SPT6 著者 Liu, J, Zhang, J, Wu, J, Shi, Y. 登録日 2010-09-22 公開日 2011-06-15 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution structure of the tandem SH2 domains from Spt6 and their binding to the phosphorylated RNA polymerase II C-terminal domain To be Published
3PQZ	Grb7 SH2 with peptide 分子名称: Growth factor receptor-bound protein 7, cyclic peptide 著者 Wilce, J.A. 登録日 2010-11-29 公開日 2011-07-20 最終更新日 2011-09-21 実験手法 X-RAY DIFFRACTION (2.413 Å) 主引用文献 Structural basis of binding by cyclic nonphosphorylated Peptide antagonists of grb7 implicated in breast cancer progression J.Mol.Biol., 412, 2011
3TL0	Structure of SHP2 N-SH2 domain in complex with RLNpYAQLWHR peptide 分子名称: RLNpYAQLWHR peptide, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. 登録日 2011-08-29 公開日 2011-09-28 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
2L6K	Solution Structure of a Nonphosphorylated Peptide Recognizing Domain 分子名称: Tensin-like C1 domain-containing phosphatase 著者 Dai, K, Liao, S, Zhang, J, Zhang, X, Tu, X. 登録日 2010-11-22 公開日 2011-10-12 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution structure of Tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1 Plos One, 6, 2011
3TKZ	Structure of the SHP-2 N-SH2 domain in a 1:2 complex with RVIpYFVPLNR peptide 分子名称: PROTEIN (RVIpYFVPLNR peptide), Tyrosine-protein phosphatase non-receptor type 11 著者 Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. 登録日 2011-08-29 公開日 2011-10-26 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
3S8N	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide 分子名称: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ... 著者 Clements, J.H, Stephen, F.M. 登録日 2011-05-29 公開日 2011-11-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011

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