5SYB
| Crystal structure of human PHF5A | 分子名称: | 1,2-ETHANEDIOL, PHD finger-like domain-containing protein 5A, ZINC ION | 著者 | Tsai, J.H.C, Teng, T, Zhu, P, Fekkes, P, Larsen, N.A. | 登録日 | 2016-08-10 | 公開日 | 2016-09-07 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex. Nat Commun, 8, 2017
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7Q4O
| Substrate-bound A-like U2 snRNP | 分子名称: | BPS oligo, PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, ... | 著者 | Tholen, J, Galej, W.P. | 登録日 | 2021-11-01 | 公開日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
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7Q4P
| U2 snRNP after ATP-dependent remodelling | 分子名称: | PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, Splicing factor 3A subunit 3, ... | 著者 | Tholen, J, Galej, W.P. | 登録日 | 2021-11-01 | 公開日 | 2022-03-30 | 最終更新日 | 2022-04-06 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
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7Q3L
| Human 17S U2 snRNP 5' domain | 分子名称: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ... | 著者 | Tholen, J, Galej, W.P. | 登録日 | 2021-10-28 | 公開日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
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7B9C
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7EVO
| The cryo-EM structure of the human 17S U2 snRNP | 分子名称: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, RNA helicase, ... | 著者 | Zhang, X, Zhan, X, Shi, Y. | 登録日 | 2021-05-21 | 公開日 | 2022-08-03 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural insights into branch site proofreading by human spliceosome. Nat.Struct.Mol.Biol., 2024
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8H6L
| Cryo-EM structure of human exon-defined spliceosome in the early B state. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | 登録日 | 2022-10-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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7EVN
| The cryo-EM structure of the DDX42-SF3b complex | 分子名称: | ATP-dependent RNA helicase DDX42, PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, ... | 著者 | Zhang, X, Zhan, X, Shi, Y. | 登録日 | 2021-05-21 | 公開日 | 2022-08-03 | 最終更新日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural insights into branch site proofreading by human spliceosome Nat.Struct.Mol.Biol., 2024
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8HK1
| The cryo-EM structure of human pre-17S U2 snRNP | 分子名称: | ATP-dependent RNA helicase DDX42, HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, ... | 著者 | Zhang, X, Zhan, X, Shi, Y. | 登録日 | 2022-11-24 | 公開日 | 2023-03-08 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly. Nat Commun, 14, 2023
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8H6K
| Cryo-EM structure of human exon-defined spliceosome in the mature B state. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | 登録日 | 2022-10-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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7DVQ
| Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'-O-[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine, Armadillo repeat-containing protein 7, ... | 著者 | Bai, R, Wan, R, Wang, L, Xu, K, Zhang, Q, Lei, J, Shi, Y. | 登録日 | 2021-01-14 | 公開日 | 2021-03-31 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structure of the activated human minor spliceosome. Science, 371, 2021
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7B0I
| Structure of a minimal SF3B core in complex with spliceostatin A (form II) | 分子名称: | PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3,Splicing factor 3B subunit 3,Splicing factor 3B subunit 3, ... | 著者 | Cretu, C, Pena, V. | 登録日 | 2020-11-19 | 公開日 | 2021-08-04 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
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7VPX
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7OMF
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7B92
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7B91
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6EN4
| SF3b core in complex with a splicing modulator | 分子名称: | PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ... | 著者 | Cretu, C, Pena, V. | 登録日 | 2017-10-04 | 公開日 | 2018-06-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.08 Å) | 主引用文献 | Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds. Mol. Cell, 70, 2018
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7QTT
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5IFE
| Crystal structure of the human SF3b core complex | 分子名称: | PHD finger-like domain-containing protein 5A, POTASSIUM ION, Splicing factor 3B subunit 1, ... | 著者 | Cretu, C, Dybkov, O, De Laurentiis, E, Will, C.L, Luhrmann, R, Pena, V. | 登録日 | 2016-02-25 | 公開日 | 2016-10-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations. Mol.Cell, 64, 2016
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7OPI
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7ONB
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8H6E
| Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | 登録日 | 2022-10-17 | 公開日 | 2024-05-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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8H6J
| Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, W, Zhan, X, Zhang, X, Lei, J, Yan, C, Shi, Y. | 登録日 | 2022-10-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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6QX9
| Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, AdML pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Charenton, C, Wilkinson, M.E, Nagai, K. | 登録日 | 2019-03-07 | 公開日 | 2019-04-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Mechanism of 5' splice site transfer for human spliceosome activation. Science, 364, 2019
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6FF4
| human Bact spliceosome core structure | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | 著者 | Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H. | 登録日 | 2018-01-03 | 公開日 | 2018-08-29 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure and Conformational Dynamics of the Human Spliceosomal BactComplex. Cell, 172, 2018
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