6QX9

Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).

This is a large structure.

Summary for 6QX9

Related6QW6
EMDB information4665 4658
DescriptorU1 snRNA, U6 snRNA, U5 small nuclear ribonucleoprotein 40 kDa protein, ... (54 entities in total)
Functional Keywordsrnp complex, splicing, rna, protein, spliceosome
Biological sourceHomo sapiens (Human)
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Total number of polymer chains71
Total molecular weight2871622.27
Authors
Charenton, C.,Wilkinson, M.E.,Nagai, K. (deposition date: 2019-03-07, release date: 2019-04-17, Last modification date: 2019-05-08)
Primary citation
Charenton, C.,Wilkinson, M.E.,Nagai, K.
Mechanism of 5' splice site transfer for human spliceosome activation.
Science, 364:362-367, 2019
PubMed: 30975767 (PDB entries with the same primary citation)
DOI: 10.1126/science.aax3289
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone12 0.3% 2.1% 0.50MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

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Molmil generated image of 6qx9
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Molmil generated image of 6qx9
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