Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).

This is a large structure.

Summary for 6QX9

EMDB information4665 4658
DescriptorU1 snRNA, U6 snRNA, U5 small nuclear ribonucleoprotein 40 kDa protein, ... (54 entities in total)
Functional Keywordsrnp complex, splicing, rna, protein, spliceosome
Biological sourceHomo sapiens (Human)
Total number of polymer chains71
Total molecular weight2871622.27
Charenton, C.,Wilkinson, M.E.,Nagai, K. (deposition date: 2019-03-07, release date: 2019-04-17, Last modification date: 2019-05-08)
Primary citation
Charenton, C.,Wilkinson, M.E.,Nagai, K.
Mechanism of 5' splice site transfer for human spliceosome activation.
Science, 364:362-367, 2019
PubMed: 30975767 (PDB entries with the same primary citation)
DOI: 10.1126/science.aax3289
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone12 0.3% 2.1% 0.50MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 6qx9
no rotation
Molmil generated image of 6qx9
rotated about x axis by 90°
Molmil generated image of 6qx9
rotated about y axis by 90°