6QX9

Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
11	0000243	cellular_component	commitment complex
11	0000244	biological_process	spliceosomal tri-snRNP complex assembly
11	0000245	biological_process	spliceosomal complex assembly
11	0000387	biological_process	spliceosomal snRNP assembly
11	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
11	0000398	biological_process	mRNA splicing, via spliceosome
11	0003723	molecular_function	RNA binding
11	0005515	molecular_function	protein binding
11	0005634	cellular_component	nucleus
11	0005654	cellular_component	nucleoplasm
11	0005681	cellular_component	spliceosomal complex
11	0005682	cellular_component	U5 snRNP
11	0005684	cellular_component	U2-type spliceosomal complex
11	0005685	cellular_component	U1 snRNP
11	0005686	cellular_component	U2 snRNP
11	0005687	cellular_component	U4 snRNP
11	0005689	cellular_component	U12-type spliceosomal complex
11	0005737	cellular_component	cytoplasm
11	0005829	cellular_component	cytosol
11	0006396	biological_process	RNA processing
11	0006397	biological_process	mRNA processing
11	0008380	biological_process	RNA splicing
11	0030532	cellular_component	small nuclear ribonucleoprotein complex
11	0034709	cellular_component	methylosome
11	0034715	cellular_component	pICln-Sm protein complex
11	0034719	cellular_component	SMN-Sm protein complex
11	0036261	biological_process	7-methylguanosine cap hypermethylation
11	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
11	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
11	0071005	cellular_component	U2-type precatalytic spliceosome
11	0071007	cellular_component	U2-type catalytic step 2 spliceosome
11	0071011	cellular_component	precatalytic spliceosome
11	0071013	cellular_component	catalytic step 2 spliceosome
11	0097526	cellular_component	spliceosomal tri-snRNP complex
11	1903241	biological_process	U2-type prespliceosome assembly
11	1990446	molecular_function	U1 snRNP binding
11	1990904	cellular_component	ribonucleoprotein complex
12	0000244	biological_process	spliceosomal tri-snRNP complex assembly
12	0000245	biological_process	spliceosomal complex assembly
12	0000387	biological_process	spliceosomal snRNP assembly
12	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
12	0000398	biological_process	mRNA splicing, via spliceosome
12	0003723	molecular_function	RNA binding
12	0005515	molecular_function	protein binding
12	0005634	cellular_component	nucleus
12	0005654	cellular_component	nucleoplasm
12	0005681	cellular_component	spliceosomal complex
12	0005682	cellular_component	U5 snRNP
12	0005684	cellular_component	U2-type spliceosomal complex
12	0005685	cellular_component	U1 snRNP
12	0005686	cellular_component	U2 snRNP
12	0005687	cellular_component	U4 snRNP
12	0005689	cellular_component	U12-type spliceosomal complex
12	0005829	cellular_component	cytosol
12	0006397	biological_process	mRNA processing
12	0008380	biological_process	RNA splicing
12	0030532	cellular_component	small nuclear ribonucleoprotein complex
12	0034709	cellular_component	methylosome
12	0034715	cellular_component	pICln-Sm protein complex
12	0034719	cellular_component	SMN-Sm protein complex
12	0036261	biological_process	7-methylguanosine cap hypermethylation
12	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
12	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
12	0070062	cellular_component	extracellular exosome
12	0071005	cellular_component	U2-type precatalytic spliceosome
12	0071007	cellular_component	U2-type catalytic step 2 spliceosome
12	0071011	cellular_component	precatalytic spliceosome
12	0071013	cellular_component	catalytic step 2 spliceosome
12	0097525	cellular_component	spliceosomal snRNP complex
12	1903241	biological_process	U2-type prespliceosome assembly
12	1990904	cellular_component	ribonucleoprotein complex
13	0000243	cellular_component	commitment complex
13	0000244	biological_process	spliceosomal tri-snRNP complex assembly
13	0000245	biological_process	spliceosomal complex assembly
13	0000387	biological_process	spliceosomal snRNP assembly
13	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
13	0000398	biological_process	mRNA splicing, via spliceosome
13	0003723	molecular_function	RNA binding
13	0005515	molecular_function	protein binding
13	0005634	cellular_component	nucleus
13	0005654	cellular_component	nucleoplasm
13	0005681	cellular_component	spliceosomal complex
13	0005682	cellular_component	U5 snRNP
13	0005683	cellular_component	U7 snRNP
13	0005684	cellular_component	U2-type spliceosomal complex
13	0005685	cellular_component	U1 snRNP
13	0005686	cellular_component	U2 snRNP
13	0005687	cellular_component	U4 snRNP
13	0005689	cellular_component	U12-type spliceosomal complex
13	0005697	cellular_component	telomerase holoenzyme complex
13	0005737	cellular_component	cytoplasm
13	0005829	cellular_component	cytosol
13	0006396	biological_process	RNA processing
13	0006397	biological_process	mRNA processing
13	0006479	biological_process	protein methylation
13	0008380	biological_process	RNA splicing
13	0016604	cellular_component	nuclear body
13	0019899	molecular_function	enzyme binding
13	0030532	cellular_component	small nuclear ribonucleoprotein complex
13	0034709	cellular_component	methylosome
13	0034715	cellular_component	pICln-Sm protein complex
13	0034719	cellular_component	SMN-Sm protein complex
13	0036261	biological_process	7-methylguanosine cap hypermethylation
13	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
13	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
13	0070034	molecular_function	telomerase RNA binding
13	0071005	cellular_component	U2-type precatalytic spliceosome
13	0071007	cellular_component	U2-type catalytic step 2 spliceosome
13	0071011	cellular_component	precatalytic spliceosome
13	0071013	cellular_component	catalytic step 2 spliceosome
13	0071045	biological_process	nuclear histone mRNA catabolic process
13	0071208	molecular_function	histone pre-mRNA DCP binding
13	0071209	molecular_function	U7 snRNA binding
13	0097526	cellular_component	spliceosomal tri-snRNP complex
13	1903241	biological_process	U2-type prespliceosome assembly
13	1990904	cellular_component	ribonucleoprotein complex
1A	0000387	biological_process	spliceosomal snRNP assembly
1A	0000398	biological_process	mRNA splicing, via spliceosome
1A	0003676	molecular_function	nucleic acid binding
1A	0003677	molecular_function	DNA binding
1A	0003723	molecular_function	RNA binding
1A	0005515	molecular_function	protein binding
1A	0005634	cellular_component	nucleus
1A	0005654	cellular_component	nucleoplasm
1A	0005681	cellular_component	spliceosomal complex
1A	0005685	cellular_component	U1 snRNP
1A	0006397	biological_process	mRNA processing
1A	0008380	biological_process	RNA splicing
1A	0030619	molecular_function	U1 snRNA binding
1A	0042802	molecular_function	identical protein binding
1A	0097525	cellular_component	spliceosomal snRNP complex
1A	1990446	molecular_function	U1 snRNP binding
1A	1990904	cellular_component	ribonucleoprotein complex
1C	0000243	cellular_component	commitment complex
1C	0000387	biological_process	spliceosomal snRNP assembly
1C	0000395	biological_process	mRNA 5'-splice site recognition
1C	0000398	biological_process	mRNA splicing, via spliceosome
1C	0003676	molecular_function	nucleic acid binding
1C	0003723	molecular_function	RNA binding
1C	0003727	molecular_function	single-stranded RNA binding
1C	0003729	molecular_function	mRNA binding
1C	0005515	molecular_function	protein binding
1C	0005634	cellular_component	nucleus
1C	0005654	cellular_component	nucleoplasm
1C	0005685	cellular_component	U1 snRNP
1C	0008270	molecular_function	zinc ion binding
1C	0015030	cellular_component	Cajal body
1C	0030619	molecular_function	U1 snRNA binding
1C	0030627	molecular_function	pre-mRNA 5'-splice site binding
1C	0042803	molecular_function	protein homodimerization activity
1C	0046872	molecular_function	metal ion binding
1C	0071004	cellular_component	U2-type prespliceosome
1C	1990904	cellular_component	ribonucleoprotein complex
1K	0000387	biological_process	spliceosomal snRNP assembly
1K	0000398	biological_process	mRNA splicing, via spliceosome
1K	0003676	molecular_function	nucleic acid binding
1K	0003723	molecular_function	RNA binding
1K	0003729	molecular_function	mRNA binding
1K	0005515	molecular_function	protein binding
1K	0005634	cellular_component	nucleus
1K	0005654	cellular_component	nucleoplasm
1K	0005681	cellular_component	spliceosomal complex
1K	0005685	cellular_component	U1 snRNP
1K	0006397	biological_process	mRNA processing
1K	0016607	cellular_component	nuclear speck
1K	0030619	molecular_function	U1 snRNA binding
1K	0043202	cellular_component	lysosomal lumen
1K	0043484	biological_process	regulation of RNA splicing
1K	0061084	biological_process	negative regulation of protein refolding
1K	0071004	cellular_component	U2-type prespliceosome
1K	0071300	biological_process	cellular response to retinoic acid
1K	0071356	biological_process	cellular response to tumor necrosis factor
1K	0071560	biological_process	cellular response to transforming growth factor beta stimulus
1K	1904715	biological_process	negative regulation of chaperone-mediated autophagy
1K	1990446	molecular_function	U1 snRNP binding
1K	1990904	cellular_component	ribonucleoprotein complex
1b	0000244	biological_process	spliceosomal tri-snRNP complex assembly
1b	0000245	biological_process	spliceosomal complex assembly
1b	0000387	biological_process	spliceosomal snRNP assembly
1b	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
1b	0000398	biological_process	mRNA splicing, via spliceosome
1b	0003723	molecular_function	RNA binding
1b	0005515	molecular_function	protein binding
1b	0005634	cellular_component	nucleus
1b	0005654	cellular_component	nucleoplasm
1b	0005681	cellular_component	spliceosomal complex
1b	0005682	cellular_component	U5 snRNP
1b	0005683	cellular_component	U7 snRNP
1b	0005684	cellular_component	U2-type spliceosomal complex
1b	0005685	cellular_component	U1 snRNP
1b	0005686	cellular_component	U2 snRNP
1b	0005687	cellular_component	U4 snRNP
1b	0005689	cellular_component	U12-type spliceosomal complex
1b	0005697	cellular_component	telomerase holoenzyme complex
1b	0005737	cellular_component	cytoplasm
1b	0005829	cellular_component	cytosol
1b	0006397	biological_process	mRNA processing
1b	0006479	biological_process	protein methylation
1b	0008380	biological_process	RNA splicing
1b	0030532	cellular_component	small nuclear ribonucleoprotein complex
1b	0034709	cellular_component	methylosome
1b	0034719	cellular_component	SMN-Sm protein complex
1b	0036261	biological_process	7-methylguanosine cap hypermethylation
1b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
1b	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
1b	0070034	molecular_function	telomerase RNA binding
1b	0070990	molecular_function	snRNP binding
1b	0071004	cellular_component	U2-type prespliceosome
1b	0071005	cellular_component	U2-type precatalytic spliceosome
1b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
1b	0071013	cellular_component	catalytic step 2 spliceosome
1b	0071045	biological_process	nuclear histone mRNA catabolic process
1b	0071204	cellular_component	histone pre-mRNA 3'end processing complex
1b	0071208	molecular_function	histone pre-mRNA DCP binding
1b	1903241	biological_process	U2-type prespliceosome assembly
1b	1990446	molecular_function	U1 snRNP binding
1b	1990447	molecular_function	U2 snRNP binding
1b	1990904	cellular_component	ribonucleoprotein complex
1e	0000244	biological_process	spliceosomal tri-snRNP complex assembly
1e	0000245	biological_process	spliceosomal complex assembly
1e	0000387	biological_process	spliceosomal snRNP assembly
1e	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
1e	0000398	biological_process	mRNA splicing, via spliceosome
1e	0003723	molecular_function	RNA binding
1e	0005515	molecular_function	protein binding
1e	0005634	cellular_component	nucleus
1e	0005654	cellular_component	nucleoplasm
1e	0005681	cellular_component	spliceosomal complex
1e	0005682	cellular_component	U5 snRNP
1e	0005683	cellular_component	U7 snRNP
1e	0005684	cellular_component	U2-type spliceosomal complex
1e	0005685	cellular_component	U1 snRNP
1e	0005686	cellular_component	U2 snRNP
1e	0005687	cellular_component	U4 snRNP
1e	0005689	cellular_component	U12-type spliceosomal complex
1e	0005697	cellular_component	telomerase holoenzyme complex
1e	0005829	cellular_component	cytosol
1e	0006397	biological_process	mRNA processing
1e	0008380	biological_process	RNA splicing
1e	0030532	cellular_component	small nuclear ribonucleoprotein complex
1e	0034709	cellular_component	methylosome
1e	0034715	cellular_component	pICln-Sm protein complex
1e	0034719	cellular_component	SMN-Sm protein complex
1e	0036261	biological_process	7-methylguanosine cap hypermethylation
1e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
1e	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
1e	0071005	cellular_component	U2-type precatalytic spliceosome
1e	0071007	cellular_component	U2-type catalytic step 2 spliceosome
1e	0071011	cellular_component	precatalytic spliceosome
1e	0071013	cellular_component	catalytic step 2 spliceosome
1e	0071045	biological_process	nuclear histone mRNA catabolic process
1e	1903241	biological_process	U2-type prespliceosome assembly
1e	1990904	cellular_component	ribonucleoprotein complex
1f	0000244	biological_process	spliceosomal tri-snRNP complex assembly
1f	0000245	biological_process	spliceosomal complex assembly
1f	0000387	biological_process	spliceosomal snRNP assembly
1f	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
1f	0000398	biological_process	mRNA splicing, via spliceosome
1f	0003723	molecular_function	RNA binding
1f	0005515	molecular_function	protein binding
1f	0005634	cellular_component	nucleus
1f	0005654	cellular_component	nucleoplasm
1f	0005681	cellular_component	spliceosomal complex
1f	0005683	cellular_component	U7 snRNP
1f	0005684	cellular_component	U2-type spliceosomal complex
1f	0005685	cellular_component	U1 snRNP
1f	0005687	cellular_component	U4 snRNP
1f	0005689	cellular_component	U12-type spliceosomal complex
1f	0005829	cellular_component	cytosol
1f	0006397	biological_process	mRNA processing
1f	0008380	biological_process	RNA splicing
1f	0022618	biological_process	protein-RNA complex assembly
1f	0030532	cellular_component	small nuclear ribonucleoprotein complex
1f	0034709	cellular_component	methylosome
1f	0034715	cellular_component	pICln-Sm protein complex
1f	0034719	cellular_component	SMN-Sm protein complex
1f	0036261	biological_process	7-methylguanosine cap hypermethylation
1f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
1f	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
1f	0071005	cellular_component	U2-type precatalytic spliceosome
1f	0071007	cellular_component	U2-type catalytic step 2 spliceosome
1f	0071013	cellular_component	catalytic step 2 spliceosome
1f	0071045	biological_process	nuclear histone mRNA catabolic process
1f	1903241	biological_process	U2-type prespliceosome assembly
1f	1990904	cellular_component	ribonucleoprotein complex
1g	0000244	biological_process	spliceosomal tri-snRNP complex assembly
1g	0000245	biological_process	spliceosomal complex assembly
1g	0000387	biological_process	spliceosomal snRNP assembly
1g	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
1g	0000398	biological_process	mRNA splicing, via spliceosome
1g	0003723	molecular_function	RNA binding
1g	0005515	molecular_function	protein binding
1g	0005634	cellular_component	nucleus
1g	0005654	cellular_component	nucleoplasm
1g	0005681	cellular_component	spliceosomal complex
1g	0005682	cellular_component	U5 snRNP
1g	0005683	cellular_component	U7 snRNP
1g	0005684	cellular_component	U2-type spliceosomal complex
1g	0005685	cellular_component	U1 snRNP
1g	0005686	cellular_component	U2 snRNP
1g	0005687	cellular_component	U4 snRNP
1g	0005689	cellular_component	U12-type spliceosomal complex
1g	0005829	cellular_component	cytosol
1g	0006397	biological_process	mRNA processing
1g	0008380	biological_process	RNA splicing
1g	0030532	cellular_component	small nuclear ribonucleoprotein complex
1g	0034709	cellular_component	methylosome
1g	0034719	cellular_component	SMN-Sm protein complex
1g	0036261	biological_process	7-methylguanosine cap hypermethylation
1g	0043186	cellular_component	P granule
1g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
1g	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
1g	0071004	cellular_component	U2-type prespliceosome
1g	0071005	cellular_component	U2-type precatalytic spliceosome
1g	0071007	cellular_component	U2-type catalytic step 2 spliceosome
1g	0071011	cellular_component	precatalytic spliceosome
1g	0071013	cellular_component	catalytic step 2 spliceosome
1g	0071045	biological_process	nuclear histone mRNA catabolic process
1g	0097526	cellular_component	spliceosomal tri-snRNP complex
1g	1903241	biological_process	U2-type prespliceosome assembly
1g	1990904	cellular_component	ribonucleoprotein complex
21	0000243	cellular_component	commitment complex
21	0000244	biological_process	spliceosomal tri-snRNP complex assembly
21	0000245	biological_process	spliceosomal complex assembly
21	0000387	biological_process	spliceosomal snRNP assembly
21	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
21	0000398	biological_process	mRNA splicing, via spliceosome
21	0003723	molecular_function	RNA binding
21	0005515	molecular_function	protein binding
21	0005634	cellular_component	nucleus
21	0005654	cellular_component	nucleoplasm
21	0005681	cellular_component	spliceosomal complex
21	0005682	cellular_component	U5 snRNP
21	0005684	cellular_component	U2-type spliceosomal complex
21	0005685	cellular_component	U1 snRNP
21	0005686	cellular_component	U2 snRNP
21	0005687	cellular_component	U4 snRNP
21	0005689	cellular_component	U12-type spliceosomal complex
21	0005737	cellular_component	cytoplasm
21	0005829	cellular_component	cytosol
21	0006396	biological_process	RNA processing
21	0006397	biological_process	mRNA processing
21	0008380	biological_process	RNA splicing
21	0030532	cellular_component	small nuclear ribonucleoprotein complex
21	0034709	cellular_component	methylosome
21	0034715	cellular_component	pICln-Sm protein complex
21	0034719	cellular_component	SMN-Sm protein complex
21	0036261	biological_process	7-methylguanosine cap hypermethylation
21	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
21	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
21	0071005	cellular_component	U2-type precatalytic spliceosome
21	0071007	cellular_component	U2-type catalytic step 2 spliceosome
21	0071011	cellular_component	precatalytic spliceosome
21	0071013	cellular_component	catalytic step 2 spliceosome
21	0097526	cellular_component	spliceosomal tri-snRNP complex
21	1903241	biological_process	U2-type prespliceosome assembly
21	1990446	molecular_function	U1 snRNP binding
21	1990904	cellular_component	ribonucleoprotein complex
22	0000244	biological_process	spliceosomal tri-snRNP complex assembly
22	0000245	biological_process	spliceosomal complex assembly
22	0000387	biological_process	spliceosomal snRNP assembly
22	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
22	0000398	biological_process	mRNA splicing, via spliceosome
22	0003723	molecular_function	RNA binding
22	0005515	molecular_function	protein binding
22	0005634	cellular_component	nucleus
22	0005654	cellular_component	nucleoplasm
22	0005681	cellular_component	spliceosomal complex
22	0005682	cellular_component	U5 snRNP
22	0005684	cellular_component	U2-type spliceosomal complex
22	0005685	cellular_component	U1 snRNP
22	0005686	cellular_component	U2 snRNP
22	0005687	cellular_component	U4 snRNP
22	0005689	cellular_component	U12-type spliceosomal complex
22	0005829	cellular_component	cytosol
22	0006397	biological_process	mRNA processing
22	0008380	biological_process	RNA splicing
22	0030532	cellular_component	small nuclear ribonucleoprotein complex
22	0034709	cellular_component	methylosome
22	0034715	cellular_component	pICln-Sm protein complex
22	0034719	cellular_component	SMN-Sm protein complex
22	0036261	biological_process	7-methylguanosine cap hypermethylation
22	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
22	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
22	0070062	cellular_component	extracellular exosome
22	0071005	cellular_component	U2-type precatalytic spliceosome
22	0071007	cellular_component	U2-type catalytic step 2 spliceosome
22	0071011	cellular_component	precatalytic spliceosome
22	0071013	cellular_component	catalytic step 2 spliceosome
22	0097525	cellular_component	spliceosomal snRNP complex
22	1903241	biological_process	U2-type prespliceosome assembly
22	1990904	cellular_component	ribonucleoprotein complex
23	0000243	cellular_component	commitment complex
23	0000244	biological_process	spliceosomal tri-snRNP complex assembly
23	0000245	biological_process	spliceosomal complex assembly
23	0000387	biological_process	spliceosomal snRNP assembly
23	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
23	0000398	biological_process	mRNA splicing, via spliceosome
23	0003723	molecular_function	RNA binding
23	0005515	molecular_function	protein binding
23	0005634	cellular_component	nucleus
23	0005654	cellular_component	nucleoplasm
23	0005681	cellular_component	spliceosomal complex
23	0005682	cellular_component	U5 snRNP
23	0005683	cellular_component	U7 snRNP
23	0005684	cellular_component	U2-type spliceosomal complex
23	0005685	cellular_component	U1 snRNP
23	0005686	cellular_component	U2 snRNP
23	0005687	cellular_component	U4 snRNP
23	0005689	cellular_component	U12-type spliceosomal complex
23	0005697	cellular_component	telomerase holoenzyme complex
23	0005737	cellular_component	cytoplasm
23	0005829	cellular_component	cytosol
23	0006396	biological_process	RNA processing
23	0006397	biological_process	mRNA processing
23	0006479	biological_process	protein methylation
23	0008380	biological_process	RNA splicing
23	0016604	cellular_component	nuclear body
23	0019899	molecular_function	enzyme binding
23	0030532	cellular_component	small nuclear ribonucleoprotein complex
23	0034709	cellular_component	methylosome
23	0034715	cellular_component	pICln-Sm protein complex
23	0034719	cellular_component	SMN-Sm protein complex
23	0036261	biological_process	7-methylguanosine cap hypermethylation
23	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
23	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
23	0070034	molecular_function	telomerase RNA binding
23	0071005	cellular_component	U2-type precatalytic spliceosome
23	0071007	cellular_component	U2-type catalytic step 2 spliceosome
23	0071011	cellular_component	precatalytic spliceosome
23	0071013	cellular_component	catalytic step 2 spliceosome
23	0071045	biological_process	nuclear histone mRNA catabolic process
23	0071208	molecular_function	histone pre-mRNA DCP binding
23	0071209	molecular_function	U7 snRNA binding
23	0097526	cellular_component	spliceosomal tri-snRNP complex
23	1903241	biological_process	U2-type prespliceosome assembly
23	1990904	cellular_component	ribonucleoprotein complex
2A	0000387	biological_process	spliceosomal snRNP assembly
2A	0000398	biological_process	mRNA splicing, via spliceosome
2A	0003723	molecular_function	RNA binding
2A	0005515	molecular_function	protein binding
2A	0005634	cellular_component	nucleus
2A	0005654	cellular_component	nucleoplasm
2A	0005681	cellular_component	spliceosomal complex
2A	0005684	cellular_component	U2-type spliceosomal complex
2A	0005686	cellular_component	U2 snRNP
2A	0006397	biological_process	mRNA processing
2A	0007283	biological_process	spermatogenesis
2A	0008380	biological_process	RNA splicing
2A	0016604	cellular_component	nuclear body
2A	0016607	cellular_component	nuclear speck
2A	0030532	cellular_component	small nuclear ribonucleoprotein complex
2A	0030620	molecular_function	U2 snRNA binding
2A	0071005	cellular_component	U2-type precatalytic spliceosome
2A	0071007	cellular_component	U2-type catalytic step 2 spliceosome
2A	0071013	cellular_component	catalytic step 2 spliceosome
2A	1903241	biological_process	U2-type prespliceosome assembly
2A	1990904	cellular_component	ribonucleoprotein complex
2B	0000387	biological_process	spliceosomal snRNP assembly
2B	0000398	biological_process	mRNA splicing, via spliceosome
2B	0003676	molecular_function	nucleic acid binding
2B	0003723	molecular_function	RNA binding
2B	0005515	molecular_function	protein binding
2B	0005634	cellular_component	nucleus
2B	0005654	cellular_component	nucleoplasm
2B	0005681	cellular_component	spliceosomal complex
2B	0005684	cellular_component	U2-type spliceosomal complex
2B	0005685	cellular_component	U1 snRNP
2B	0005686	cellular_component	U2 snRNP
2B	0006397	biological_process	mRNA processing
2B	0008380	biological_process	RNA splicing
2B	0016607	cellular_component	nuclear speck
2B	0030619	molecular_function	U1 snRNA binding
2B	0071005	cellular_component	U2-type precatalytic spliceosome
2B	0071007	cellular_component	U2-type catalytic step 2 spliceosome
2B	0071013	cellular_component	catalytic step 2 spliceosome
2B	0097525	cellular_component	spliceosomal snRNP complex
2B	1903241	biological_process	U2-type prespliceosome assembly
2B	1990904	cellular_component	ribonucleoprotein complex
2b	0000244	biological_process	spliceosomal tri-snRNP complex assembly
2b	0000245	biological_process	spliceosomal complex assembly
2b	0000387	biological_process	spliceosomal snRNP assembly
2b	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
2b	0000398	biological_process	mRNA splicing, via spliceosome
2b	0003723	molecular_function	RNA binding
2b	0005515	molecular_function	protein binding
2b	0005634	cellular_component	nucleus
2b	0005654	cellular_component	nucleoplasm
2b	0005681	cellular_component	spliceosomal complex
2b	0005682	cellular_component	U5 snRNP
2b	0005683	cellular_component	U7 snRNP
2b	0005684	cellular_component	U2-type spliceosomal complex
2b	0005685	cellular_component	U1 snRNP
2b	0005686	cellular_component	U2 snRNP
2b	0005687	cellular_component	U4 snRNP
2b	0005689	cellular_component	U12-type spliceosomal complex
2b	0005697	cellular_component	telomerase holoenzyme complex
2b	0005737	cellular_component	cytoplasm
2b	0005829	cellular_component	cytosol
2b	0006397	biological_process	mRNA processing
2b	0006479	biological_process	protein methylation
2b	0008380	biological_process	RNA splicing
2b	0030532	cellular_component	small nuclear ribonucleoprotein complex
2b	0034709	cellular_component	methylosome
2b	0034719	cellular_component	SMN-Sm protein complex
2b	0036261	biological_process	7-methylguanosine cap hypermethylation
2b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
2b	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
2b	0070034	molecular_function	telomerase RNA binding
2b	0070990	molecular_function	snRNP binding
2b	0071004	cellular_component	U2-type prespliceosome
2b	0071005	cellular_component	U2-type precatalytic spliceosome
2b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
2b	0071013	cellular_component	catalytic step 2 spliceosome
2b	0071045	biological_process	nuclear histone mRNA catabolic process
2b	0071204	cellular_component	histone pre-mRNA 3'end processing complex
2b	0071208	molecular_function	histone pre-mRNA DCP binding
2b	1903241	biological_process	U2-type prespliceosome assembly
2b	1990446	molecular_function	U1 snRNP binding
2b	1990447	molecular_function	U2 snRNP binding
2b	1990904	cellular_component	ribonucleoprotein complex
2e	0000244	biological_process	spliceosomal tri-snRNP complex assembly
2e	0000245	biological_process	spliceosomal complex assembly
2e	0000387	biological_process	spliceosomal snRNP assembly
2e	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
2e	0000398	biological_process	mRNA splicing, via spliceosome
2e	0003723	molecular_function	RNA binding
2e	0005515	molecular_function	protein binding
2e	0005634	cellular_component	nucleus
2e	0005654	cellular_component	nucleoplasm
2e	0005681	cellular_component	spliceosomal complex
2e	0005682	cellular_component	U5 snRNP
2e	0005683	cellular_component	U7 snRNP
2e	0005684	cellular_component	U2-type spliceosomal complex
2e	0005685	cellular_component	U1 snRNP
2e	0005686	cellular_component	U2 snRNP
2e	0005687	cellular_component	U4 snRNP
2e	0005689	cellular_component	U12-type spliceosomal complex
2e	0005697	cellular_component	telomerase holoenzyme complex
2e	0005829	cellular_component	cytosol
2e	0006397	biological_process	mRNA processing
2e	0008380	biological_process	RNA splicing
2e	0030532	cellular_component	small nuclear ribonucleoprotein complex
2e	0034709	cellular_component	methylosome
2e	0034715	cellular_component	pICln-Sm protein complex
2e	0034719	cellular_component	SMN-Sm protein complex
2e	0036261	biological_process	7-methylguanosine cap hypermethylation
2e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
2e	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
2e	0071005	cellular_component	U2-type precatalytic spliceosome
2e	0071007	cellular_component	U2-type catalytic step 2 spliceosome
2e	0071011	cellular_component	precatalytic spliceosome
2e	0071013	cellular_component	catalytic step 2 spliceosome
2e	0071045	biological_process	nuclear histone mRNA catabolic process
2e	1903241	biological_process	U2-type prespliceosome assembly
2e	1990904	cellular_component	ribonucleoprotein complex
2f	0000244	biological_process	spliceosomal tri-snRNP complex assembly
2f	0000245	biological_process	spliceosomal complex assembly
2f	0000387	biological_process	spliceosomal snRNP assembly
2f	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
2f	0000398	biological_process	mRNA splicing, via spliceosome
2f	0003723	molecular_function	RNA binding
2f	0005515	molecular_function	protein binding
2f	0005634	cellular_component	nucleus
2f	0005654	cellular_component	nucleoplasm
2f	0005681	cellular_component	spliceosomal complex
2f	0005683	cellular_component	U7 snRNP
2f	0005684	cellular_component	U2-type spliceosomal complex
2f	0005685	cellular_component	U1 snRNP
2f	0005687	cellular_component	U4 snRNP
2f	0005689	cellular_component	U12-type spliceosomal complex
2f	0005829	cellular_component	cytosol
2f	0006397	biological_process	mRNA processing
2f	0008380	biological_process	RNA splicing
2f	0022618	biological_process	protein-RNA complex assembly
2f	0030532	cellular_component	small nuclear ribonucleoprotein complex
2f	0034709	cellular_component	methylosome
2f	0034715	cellular_component	pICln-Sm protein complex
2f	0034719	cellular_component	SMN-Sm protein complex
2f	0036261	biological_process	7-methylguanosine cap hypermethylation
2f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
2f	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
2f	0071005	cellular_component	U2-type precatalytic spliceosome
2f	0071007	cellular_component	U2-type catalytic step 2 spliceosome
2f	0071013	cellular_component	catalytic step 2 spliceosome
2f	0071045	biological_process	nuclear histone mRNA catabolic process
2f	1903241	biological_process	U2-type prespliceosome assembly
2f	1990904	cellular_component	ribonucleoprotein complex
2g	0000244	biological_process	spliceosomal tri-snRNP complex assembly
2g	0000245	biological_process	spliceosomal complex assembly
2g	0000387	biological_process	spliceosomal snRNP assembly
2g	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
2g	0000398	biological_process	mRNA splicing, via spliceosome
2g	0003723	molecular_function	RNA binding
2g	0005515	molecular_function	protein binding
2g	0005634	cellular_component	nucleus
2g	0005654	cellular_component	nucleoplasm
2g	0005681	cellular_component	spliceosomal complex
2g	0005682	cellular_component	U5 snRNP
2g	0005683	cellular_component	U7 snRNP
2g	0005684	cellular_component	U2-type spliceosomal complex
2g	0005685	cellular_component	U1 snRNP
2g	0005686	cellular_component	U2 snRNP
2g	0005687	cellular_component	U4 snRNP
2g	0005689	cellular_component	U12-type spliceosomal complex
2g	0005829	cellular_component	cytosol
2g	0006397	biological_process	mRNA processing
2g	0008380	biological_process	RNA splicing
2g	0030532	cellular_component	small nuclear ribonucleoprotein complex
2g	0034709	cellular_component	methylosome
2g	0034719	cellular_component	SMN-Sm protein complex
2g	0036261	biological_process	7-methylguanosine cap hypermethylation
2g	0043186	cellular_component	P granule
2g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
2g	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
2g	0071004	cellular_component	U2-type prespliceosome
2g	0071005	cellular_component	U2-type precatalytic spliceosome
2g	0071007	cellular_component	U2-type catalytic step 2 spliceosome
2g	0071011	cellular_component	precatalytic spliceosome
2g	0071013	cellular_component	catalytic step 2 spliceosome
2g	0071045	biological_process	nuclear histone mRNA catabolic process
2g	0097526	cellular_component	spliceosomal tri-snRNP complex
2g	1903241	biological_process	U2-type prespliceosome assembly
2g	1990904	cellular_component	ribonucleoprotein complex
41	0000243	cellular_component	commitment complex
41	0000244	biological_process	spliceosomal tri-snRNP complex assembly
41	0000245	biological_process	spliceosomal complex assembly
41	0000387	biological_process	spliceosomal snRNP assembly
41	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
41	0000398	biological_process	mRNA splicing, via spliceosome
41	0003723	molecular_function	RNA binding
41	0005515	molecular_function	protein binding
41	0005634	cellular_component	nucleus
41	0005654	cellular_component	nucleoplasm
41	0005681	cellular_component	spliceosomal complex
41	0005682	cellular_component	U5 snRNP
41	0005684	cellular_component	U2-type spliceosomal complex
41	0005685	cellular_component	U1 snRNP
41	0005686	cellular_component	U2 snRNP
41	0005687	cellular_component	U4 snRNP
41	0005689	cellular_component	U12-type spliceosomal complex
41	0005737	cellular_component	cytoplasm
41	0005829	cellular_component	cytosol
41	0006396	biological_process	RNA processing
41	0006397	biological_process	mRNA processing
41	0008380	biological_process	RNA splicing
41	0030532	cellular_component	small nuclear ribonucleoprotein complex
41	0034709	cellular_component	methylosome
41	0034715	cellular_component	pICln-Sm protein complex
41	0034719	cellular_component	SMN-Sm protein complex
41	0036261	biological_process	7-methylguanosine cap hypermethylation
41	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
41	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
41	0071005	cellular_component	U2-type precatalytic spliceosome
41	0071007	cellular_component	U2-type catalytic step 2 spliceosome
41	0071011	cellular_component	precatalytic spliceosome
41	0071013	cellular_component	catalytic step 2 spliceosome
41	0097526	cellular_component	spliceosomal tri-snRNP complex
41	1903241	biological_process	U2-type prespliceosome assembly
41	1990446	molecular_function	U1 snRNP binding
41	1990904	cellular_component	ribonucleoprotein complex
42	0000244	biological_process	spliceosomal tri-snRNP complex assembly
42	0000245	biological_process	spliceosomal complex assembly
42	0000387	biological_process	spliceosomal snRNP assembly
42	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
42	0000398	biological_process	mRNA splicing, via spliceosome
42	0003723	molecular_function	RNA binding
42	0005515	molecular_function	protein binding
42	0005634	cellular_component	nucleus
42	0005654	cellular_component	nucleoplasm
42	0005681	cellular_component	spliceosomal complex
42	0005682	cellular_component	U5 snRNP
42	0005684	cellular_component	U2-type spliceosomal complex
42	0005685	cellular_component	U1 snRNP
42	0005686	cellular_component	U2 snRNP
42	0005687	cellular_component	U4 snRNP
42	0005689	cellular_component	U12-type spliceosomal complex
42	0005829	cellular_component	cytosol
42	0006397	biological_process	mRNA processing
42	0008380	biological_process	RNA splicing
42	0030532	cellular_component	small nuclear ribonucleoprotein complex
42	0034709	cellular_component	methylosome
42	0034715	cellular_component	pICln-Sm protein complex
42	0034719	cellular_component	SMN-Sm protein complex
42	0036261	biological_process	7-methylguanosine cap hypermethylation
42	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
42	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
42	0070062	cellular_component	extracellular exosome
42	0071005	cellular_component	U2-type precatalytic spliceosome
42	0071007	cellular_component	U2-type catalytic step 2 spliceosome
42	0071011	cellular_component	precatalytic spliceosome
42	0071013	cellular_component	catalytic step 2 spliceosome
42	0097525	cellular_component	spliceosomal snRNP complex
42	1903241	biological_process	U2-type prespliceosome assembly
42	1990904	cellular_component	ribonucleoprotein complex
43	0000243	cellular_component	commitment complex
43	0000244	biological_process	spliceosomal tri-snRNP complex assembly
43	0000245	biological_process	spliceosomal complex assembly
43	0000387	biological_process	spliceosomal snRNP assembly
43	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
43	0000398	biological_process	mRNA splicing, via spliceosome
43	0003723	molecular_function	RNA binding
43	0005515	molecular_function	protein binding
43	0005634	cellular_component	nucleus
43	0005654	cellular_component	nucleoplasm
43	0005681	cellular_component	spliceosomal complex
43	0005682	cellular_component	U5 snRNP
43	0005683	cellular_component	U7 snRNP
43	0005684	cellular_component	U2-type spliceosomal complex
43	0005685	cellular_component	U1 snRNP
43	0005686	cellular_component	U2 snRNP
43	0005687	cellular_component	U4 snRNP
43	0005689	cellular_component	U12-type spliceosomal complex
43	0005697	cellular_component	telomerase holoenzyme complex
43	0005737	cellular_component	cytoplasm
43	0005829	cellular_component	cytosol
43	0006396	biological_process	RNA processing
43	0006397	biological_process	mRNA processing
43	0006479	biological_process	protein methylation
43	0008380	biological_process	RNA splicing
43	0016604	cellular_component	nuclear body
43	0019899	molecular_function	enzyme binding
43	0030532	cellular_component	small nuclear ribonucleoprotein complex
43	0034709	cellular_component	methylosome
43	0034715	cellular_component	pICln-Sm protein complex
43	0034719	cellular_component	SMN-Sm protein complex
43	0036261	biological_process	7-methylguanosine cap hypermethylation
43	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
43	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
43	0070034	molecular_function	telomerase RNA binding
43	0071005	cellular_component	U2-type precatalytic spliceosome
43	0071007	cellular_component	U2-type catalytic step 2 spliceosome
43	0071011	cellular_component	precatalytic spliceosome
43	0071013	cellular_component	catalytic step 2 spliceosome
43	0071045	biological_process	nuclear histone mRNA catabolic process
43	0071208	molecular_function	histone pre-mRNA DCP binding
43	0071209	molecular_function	U7 snRNA binding
43	0097526	cellular_component	spliceosomal tri-snRNP complex
43	1903241	biological_process	U2-type prespliceosome assembly
43	1990904	cellular_component	ribonucleoprotein complex
4A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4A	0000245	biological_process	spliceosomal complex assembly
4A	0000375	biological_process	RNA splicing, via transesterification reactions
4A	0000387	biological_process	spliceosomal snRNP assembly
4A	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4A	0000398	biological_process	mRNA splicing, via spliceosome
4A	0003723	molecular_function	RNA binding
4A	0005515	molecular_function	protein binding
4A	0005634	cellular_component	nucleus
4A	0005654	cellular_component	nucleoplasm
4A	0005681	cellular_component	spliceosomal complex
4A	0006397	biological_process	mRNA processing
4A	0008380	biological_process	RNA splicing
4A	0015030	cellular_component	Cajal body
4A	0016607	cellular_component	nuclear speck
4A	0032991	cellular_component	protein-containing complex
4A	0042802	molecular_function	identical protein binding
4A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4A	0071005	cellular_component	U2-type precatalytic spliceosome
4B	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4B	0000245	biological_process	spliceosomal complex assembly
4B	0000375	biological_process	RNA splicing, via transesterification reactions
4B	0000387	biological_process	spliceosomal snRNP assembly
4B	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4B	0000398	biological_process	mRNA splicing, via spliceosome
4B	0005515	molecular_function	protein binding
4B	0005634	cellular_component	nucleus
4B	0005654	cellular_component	nucleoplasm
4B	0005681	cellular_component	spliceosomal complex
4B	0006396	biological_process	RNA processing
4B	0006397	biological_process	mRNA processing
4B	0008380	biological_process	RNA splicing
4B	0015030	cellular_component	Cajal body
4B	0016607	cellular_component	nuclear speck
4B	0017070	molecular_function	U6 snRNA binding
4B	0030621	molecular_function	U4 snRNA binding
4B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4B	0071001	cellular_component	U4/U6 snRNP
4B	0071005	cellular_component	U2-type precatalytic spliceosome
4B	0097525	cellular_component	spliceosomal snRNP complex
4C	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4C	0000387	biological_process	spliceosomal snRNP assembly
4C	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4C	0000398	biological_process	mRNA splicing, via spliceosome
4C	0003723	molecular_function	RNA binding
4C	0005515	molecular_function	protein binding
4C	0005634	cellular_component	nucleus
4C	0005654	cellular_component	nucleoplasm
4C	0005681	cellular_component	spliceosomal complex
4C	0005684	cellular_component	U2-type spliceosomal complex
4C	0005687	cellular_component	U4 snRNP
4C	0005690	cellular_component	U4atac snRNP
4C	0006397	biological_process	mRNA processing
4C	0008380	biological_process	RNA splicing
4C	0015030	cellular_component	Cajal body
4C	0016607	cellular_component	nuclear speck
4C	0030621	molecular_function	U4 snRNA binding
4C	0030622	molecular_function	U4atac snRNA binding
4C	0030674	molecular_function	protein-macromolecule adaptor activity
4C	0042802	molecular_function	identical protein binding
4C	0043021	molecular_function	ribonucleoprotein complex binding
4C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4C	0048254	biological_process	snoRNA localization
4C	0070990	molecular_function	snRNP binding
4C	0071005	cellular_component	U2-type precatalytic spliceosome
4C	0071011	cellular_component	precatalytic spliceosome
4C	0071166	biological_process	ribonucleoprotein complex localization
4C	0071339	cellular_component	MLL1 complex
4C	0097526	cellular_component	spliceosomal tri-snRNP complex
4C	1990904	cellular_component	ribonucleoprotein complex
4D	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4D	0000245	biological_process	spliceosomal complex assembly
4D	0000387	biological_process	spliceosomal snRNP assembly
4D	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4D	0000398	biological_process	mRNA splicing, via spliceosome
4D	0000451	biological_process	rRNA 2'-O-methylation
4D	0000492	biological_process	box C/D snoRNP assembly
4D	0001651	cellular_component	dense fibrillar component
4D	0003723	molecular_function	RNA binding
4D	0005515	molecular_function	protein binding
4D	0005634	cellular_component	nucleus
4D	0005654	cellular_component	nucleoplasm
4D	0005681	cellular_component	spliceosomal complex
4D	0005690	cellular_component	U4atac snRNP
4D	0005730	cellular_component	nucleolus
4D	0006397	biological_process	mRNA processing
4D	0008380	biological_process	RNA splicing
4D	0016556	biological_process	mRNA modification
4D	0030182	biological_process	neuron differentiation
4D	0030490	biological_process	maturation of SSU-rRNA
4D	0030515	molecular_function	snoRNA binding
4D	0030621	molecular_function	U4 snRNA binding
4D	0030622	molecular_function	U4atac snRNA binding
4D	0031428	cellular_component	box C/D methylation guide snoRNP complex
4D	0032040	cellular_component	small-subunit processome
4D	0032991	cellular_component	protein-containing complex
4D	0034511	molecular_function	U3 snoRNA binding
4D	0034512	molecular_function	box C/D sno(s)RNA binding
4D	0042254	biological_process	ribosome biogenesis
4D	0042274	biological_process	ribosomal small subunit biogenesis
4D	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4D	0051117	molecular_function	ATPase binding
4D	0071005	cellular_component	U2-type precatalytic spliceosome
4D	0071011	cellular_component	precatalytic spliceosome
4D	1990904	cellular_component	ribonucleoprotein complex
4b	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4b	0000245	biological_process	spliceosomal complex assembly
4b	0000387	biological_process	spliceosomal snRNP assembly
4b	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4b	0000398	biological_process	mRNA splicing, via spliceosome
4b	0003723	molecular_function	RNA binding
4b	0005515	molecular_function	protein binding
4b	0005634	cellular_component	nucleus
4b	0005654	cellular_component	nucleoplasm
4b	0005681	cellular_component	spliceosomal complex
4b	0005682	cellular_component	U5 snRNP
4b	0005683	cellular_component	U7 snRNP
4b	0005684	cellular_component	U2-type spliceosomal complex
4b	0005685	cellular_component	U1 snRNP
4b	0005686	cellular_component	U2 snRNP
4b	0005687	cellular_component	U4 snRNP
4b	0005689	cellular_component	U12-type spliceosomal complex
4b	0005697	cellular_component	telomerase holoenzyme complex
4b	0005737	cellular_component	cytoplasm
4b	0005829	cellular_component	cytosol
4b	0006397	biological_process	mRNA processing
4b	0006479	biological_process	protein methylation
4b	0008380	biological_process	RNA splicing
4b	0030532	cellular_component	small nuclear ribonucleoprotein complex
4b	0034709	cellular_component	methylosome
4b	0034719	cellular_component	SMN-Sm protein complex
4b	0036261	biological_process	7-methylguanosine cap hypermethylation
4b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4b	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
4b	0070034	molecular_function	telomerase RNA binding
4b	0070990	molecular_function	snRNP binding
4b	0071004	cellular_component	U2-type prespliceosome
4b	0071005	cellular_component	U2-type precatalytic spliceosome
4b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
4b	0071013	cellular_component	catalytic step 2 spliceosome
4b	0071045	biological_process	nuclear histone mRNA catabolic process
4b	0071204	cellular_component	histone pre-mRNA 3'end processing complex
4b	0071208	molecular_function	histone pre-mRNA DCP binding
4b	1903241	biological_process	U2-type prespliceosome assembly
4b	1990446	molecular_function	U1 snRNP binding
4b	1990447	molecular_function	U2 snRNP binding
4b	1990904	cellular_component	ribonucleoprotein complex
4e	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4e	0000245	biological_process	spliceosomal complex assembly
4e	0000387	biological_process	spliceosomal snRNP assembly
4e	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4e	0000398	biological_process	mRNA splicing, via spliceosome
4e	0003723	molecular_function	RNA binding
4e	0005515	molecular_function	protein binding
4e	0005634	cellular_component	nucleus
4e	0005654	cellular_component	nucleoplasm
4e	0005681	cellular_component	spliceosomal complex
4e	0005682	cellular_component	U5 snRNP
4e	0005683	cellular_component	U7 snRNP
4e	0005684	cellular_component	U2-type spliceosomal complex
4e	0005685	cellular_component	U1 snRNP
4e	0005686	cellular_component	U2 snRNP
4e	0005687	cellular_component	U4 snRNP
4e	0005689	cellular_component	U12-type spliceosomal complex
4e	0005697	cellular_component	telomerase holoenzyme complex
4e	0005829	cellular_component	cytosol
4e	0006397	biological_process	mRNA processing
4e	0008380	biological_process	RNA splicing
4e	0030532	cellular_component	small nuclear ribonucleoprotein complex
4e	0034709	cellular_component	methylosome
4e	0034715	cellular_component	pICln-Sm protein complex
4e	0034719	cellular_component	SMN-Sm protein complex
4e	0036261	biological_process	7-methylguanosine cap hypermethylation
4e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4e	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
4e	0071005	cellular_component	U2-type precatalytic spliceosome
4e	0071007	cellular_component	U2-type catalytic step 2 spliceosome
4e	0071011	cellular_component	precatalytic spliceosome
4e	0071013	cellular_component	catalytic step 2 spliceosome
4e	0071045	biological_process	nuclear histone mRNA catabolic process
4e	1903241	biological_process	U2-type prespliceosome assembly
4e	1990904	cellular_component	ribonucleoprotein complex
4f	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4f	0000245	biological_process	spliceosomal complex assembly
4f	0000387	biological_process	spliceosomal snRNP assembly
4f	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4f	0000398	biological_process	mRNA splicing, via spliceosome
4f	0003723	molecular_function	RNA binding
4f	0005515	molecular_function	protein binding
4f	0005634	cellular_component	nucleus
4f	0005654	cellular_component	nucleoplasm
4f	0005681	cellular_component	spliceosomal complex
4f	0005683	cellular_component	U7 snRNP
4f	0005684	cellular_component	U2-type spliceosomal complex
4f	0005685	cellular_component	U1 snRNP
4f	0005687	cellular_component	U4 snRNP
4f	0005689	cellular_component	U12-type spliceosomal complex
4f	0005829	cellular_component	cytosol
4f	0006397	biological_process	mRNA processing
4f	0008380	biological_process	RNA splicing
4f	0022618	biological_process	protein-RNA complex assembly
4f	0030532	cellular_component	small nuclear ribonucleoprotein complex
4f	0034709	cellular_component	methylosome
4f	0034715	cellular_component	pICln-Sm protein complex
4f	0034719	cellular_component	SMN-Sm protein complex
4f	0036261	biological_process	7-methylguanosine cap hypermethylation
4f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4f	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
4f	0071005	cellular_component	U2-type precatalytic spliceosome
4f	0071007	cellular_component	U2-type catalytic step 2 spliceosome
4f	0071013	cellular_component	catalytic step 2 spliceosome
4f	0071045	biological_process	nuclear histone mRNA catabolic process
4f	1903241	biological_process	U2-type prespliceosome assembly
4f	1990904	cellular_component	ribonucleoprotein complex
4g	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4g	0000245	biological_process	spliceosomal complex assembly
4g	0000387	biological_process	spliceosomal snRNP assembly
4g	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4g	0000398	biological_process	mRNA splicing, via spliceosome
4g	0003723	molecular_function	RNA binding
4g	0005515	molecular_function	protein binding
4g	0005634	cellular_component	nucleus
4g	0005654	cellular_component	nucleoplasm
4g	0005681	cellular_component	spliceosomal complex
4g	0005682	cellular_component	U5 snRNP
4g	0005683	cellular_component	U7 snRNP
4g	0005684	cellular_component	U2-type spliceosomal complex
4g	0005685	cellular_component	U1 snRNP
4g	0005686	cellular_component	U2 snRNP
4g	0005687	cellular_component	U4 snRNP
4g	0005689	cellular_component	U12-type spliceosomal complex
4g	0005829	cellular_component	cytosol
4g	0006397	biological_process	mRNA processing
4g	0008380	biological_process	RNA splicing
4g	0030532	cellular_component	small nuclear ribonucleoprotein complex
4g	0034709	cellular_component	methylosome
4g	0034719	cellular_component	SMN-Sm protein complex
4g	0036261	biological_process	7-methylguanosine cap hypermethylation
4g	0043186	cellular_component	P granule
4g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4g	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
4g	0071004	cellular_component	U2-type prespliceosome
4g	0071005	cellular_component	U2-type precatalytic spliceosome
4g	0071007	cellular_component	U2-type catalytic step 2 spliceosome
4g	0071011	cellular_component	precatalytic spliceosome
4g	0071013	cellular_component	catalytic step 2 spliceosome
4g	0071045	biological_process	nuclear histone mRNA catabolic process
4g	0097526	cellular_component	spliceosomal tri-snRNP complex
4g	1903241	biological_process	U2-type prespliceosome assembly
4g	1990904	cellular_component	ribonucleoprotein complex
51	0000243	cellular_component	commitment complex
51	0000244	biological_process	spliceosomal tri-snRNP complex assembly
51	0000245	biological_process	spliceosomal complex assembly
51	0000387	biological_process	spliceosomal snRNP assembly
51	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
51	0000398	biological_process	mRNA splicing, via spliceosome
51	0003723	molecular_function	RNA binding
51	0005515	molecular_function	protein binding
51	0005634	cellular_component	nucleus
51	0005654	cellular_component	nucleoplasm
51	0005681	cellular_component	spliceosomal complex
51	0005682	cellular_component	U5 snRNP
51	0005684	cellular_component	U2-type spliceosomal complex
51	0005685	cellular_component	U1 snRNP
51	0005686	cellular_component	U2 snRNP
51	0005687	cellular_component	U4 snRNP
51	0005689	cellular_component	U12-type spliceosomal complex
51	0005737	cellular_component	cytoplasm
51	0005829	cellular_component	cytosol
51	0006396	biological_process	RNA processing
51	0006397	biological_process	mRNA processing
51	0008380	biological_process	RNA splicing
51	0030532	cellular_component	small nuclear ribonucleoprotein complex
51	0034709	cellular_component	methylosome
51	0034715	cellular_component	pICln-Sm protein complex
51	0034719	cellular_component	SMN-Sm protein complex
51	0036261	biological_process	7-methylguanosine cap hypermethylation
51	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
51	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
51	0071005	cellular_component	U2-type precatalytic spliceosome
51	0071007	cellular_component	U2-type catalytic step 2 spliceosome
51	0071011	cellular_component	precatalytic spliceosome
51	0071013	cellular_component	catalytic step 2 spliceosome
51	0097526	cellular_component	spliceosomal tri-snRNP complex
51	1903241	biological_process	U2-type prespliceosome assembly
51	1990446	molecular_function	U1 snRNP binding
51	1990904	cellular_component	ribonucleoprotein complex
52	0000244	biological_process	spliceosomal tri-snRNP complex assembly
52	0000245	biological_process	spliceosomal complex assembly
52	0000387	biological_process	spliceosomal snRNP assembly
52	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
52	0000398	biological_process	mRNA splicing, via spliceosome
52	0003723	molecular_function	RNA binding
52	0005515	molecular_function	protein binding
52	0005634	cellular_component	nucleus
52	0005654	cellular_component	nucleoplasm
52	0005681	cellular_component	spliceosomal complex
52	0005682	cellular_component	U5 snRNP
52	0005684	cellular_component	U2-type spliceosomal complex
52	0005685	cellular_component	U1 snRNP
52	0005686	cellular_component	U2 snRNP
52	0005687	cellular_component	U4 snRNP
52	0005689	cellular_component	U12-type spliceosomal complex
52	0005829	cellular_component	cytosol
52	0006397	biological_process	mRNA processing
52	0008380	biological_process	RNA splicing
52	0030532	cellular_component	small nuclear ribonucleoprotein complex
52	0034709	cellular_component	methylosome
52	0034715	cellular_component	pICln-Sm protein complex
52	0034719	cellular_component	SMN-Sm protein complex
52	0036261	biological_process	7-methylguanosine cap hypermethylation
52	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
52	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
52	0070062	cellular_component	extracellular exosome
52	0071005	cellular_component	U2-type precatalytic spliceosome
52	0071007	cellular_component	U2-type catalytic step 2 spliceosome
52	0071011	cellular_component	precatalytic spliceosome
52	0071013	cellular_component	catalytic step 2 spliceosome
52	0097525	cellular_component	spliceosomal snRNP complex
52	1903241	biological_process	U2-type prespliceosome assembly
52	1990904	cellular_component	ribonucleoprotein complex
53	0000243	cellular_component	commitment complex
53	0000244	biological_process	spliceosomal tri-snRNP complex assembly
53	0000245	biological_process	spliceosomal complex assembly
53	0000387	biological_process	spliceosomal snRNP assembly
53	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
53	0000398	biological_process	mRNA splicing, via spliceosome
53	0003723	molecular_function	RNA binding
53	0005515	molecular_function	protein binding
53	0005634	cellular_component	nucleus
53	0005654	cellular_component	nucleoplasm
53	0005681	cellular_component	spliceosomal complex
53	0005682	cellular_component	U5 snRNP
53	0005683	cellular_component	U7 snRNP
53	0005684	cellular_component	U2-type spliceosomal complex
53	0005685	cellular_component	U1 snRNP
53	0005686	cellular_component	U2 snRNP
53	0005687	cellular_component	U4 snRNP
53	0005689	cellular_component	U12-type spliceosomal complex
53	0005697	cellular_component	telomerase holoenzyme complex
53	0005737	cellular_component	cytoplasm
53	0005829	cellular_component	cytosol
53	0006396	biological_process	RNA processing
53	0006397	biological_process	mRNA processing
53	0006479	biological_process	protein methylation
53	0008380	biological_process	RNA splicing
53	0016604	cellular_component	nuclear body
53	0019899	molecular_function	enzyme binding
53	0030532	cellular_component	small nuclear ribonucleoprotein complex
53	0034709	cellular_component	methylosome
53	0034715	cellular_component	pICln-Sm protein complex
53	0034719	cellular_component	SMN-Sm protein complex
53	0036261	biological_process	7-methylguanosine cap hypermethylation
53	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
53	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
53	0070034	molecular_function	telomerase RNA binding
53	0071005	cellular_component	U2-type precatalytic spliceosome
53	0071007	cellular_component	U2-type catalytic step 2 spliceosome
53	0071011	cellular_component	precatalytic spliceosome
53	0071013	cellular_component	catalytic step 2 spliceosome
53	0071045	biological_process	nuclear histone mRNA catabolic process
53	0071208	molecular_function	histone pre-mRNA DCP binding
53	0071209	molecular_function	U7 snRNA binding
53	0097526	cellular_component	spliceosomal tri-snRNP complex
53	1903241	biological_process	U2-type prespliceosome assembly
53	1990904	cellular_component	ribonucleoprotein complex
5A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5A	0000375	biological_process	RNA splicing, via transesterification reactions
5A	0000387	biological_process	spliceosomal snRNP assembly
5A	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5A	0000398	biological_process	mRNA splicing, via spliceosome
5A	0003723	molecular_function	RNA binding
5A	0005515	molecular_function	protein binding
5A	0005634	cellular_component	nucleus
5A	0005654	cellular_component	nucleoplasm
5A	0005681	cellular_component	spliceosomal complex
5A	0005682	cellular_component	U5 snRNP
5A	0006397	biological_process	mRNA processing
5A	0008233	molecular_function	peptidase activity
5A	0008237	molecular_function	metallopeptidase activity
5A	0008380	biological_process	RNA splicing
5A	0016020	cellular_component	membrane
5A	0016607	cellular_component	nuclear speck
5A	0017070	molecular_function	U6 snRNA binding
5A	0030532	cellular_component	small nuclear ribonucleoprotein complex
5A	0030619	molecular_function	U1 snRNA binding
5A	0030620	molecular_function	U2 snRNA binding
5A	0030623	molecular_function	U5 snRNA binding
5A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5A	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
5A	0070530	molecular_function	K63-linked polyubiquitin modification-dependent protein binding
5A	0071005	cellular_component	U2-type precatalytic spliceosome
5A	0071006	cellular_component	U2-type catalytic step 1 spliceosome
5A	0071007	cellular_component	U2-type catalytic step 2 spliceosome
5A	0071013	cellular_component	catalytic step 2 spliceosome
5A	0071222	biological_process	cellular response to lipopolysaccharide
5A	0071356	biological_process	cellular response to tumor necrosis factor
5A	0097157	molecular_function	pre-mRNA intronic binding
5A	0140492	molecular_function	metal-dependent deubiquitinase activity
5A	1990904	cellular_component	ribonucleoprotein complex
5B	0000166	molecular_function	nucleotide binding
5B	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5B	0000354	biological_process	cis assembly of pre-catalytic spliceosome
5B	0000387	biological_process	spliceosomal snRNP assembly
5B	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5B	0000398	biological_process	mRNA splicing, via spliceosome
5B	0001649	biological_process	osteoblast differentiation
5B	0003676	molecular_function	nucleic acid binding
5B	0003723	molecular_function	RNA binding
5B	0003724	molecular_function	RNA helicase activity
5B	0004386	molecular_function	helicase activity
5B	0005515	molecular_function	protein binding
5B	0005524	molecular_function	ATP binding
5B	0005634	cellular_component	nucleus
5B	0005654	cellular_component	nucleoplasm
5B	0005681	cellular_component	spliceosomal complex
5B	0005682	cellular_component	U5 snRNP
5B	0006397	biological_process	mRNA processing
5B	0008380	biological_process	RNA splicing
5B	0016020	cellular_component	membrane
5B	0016787	molecular_function	hydrolase activity
5B	0016887	molecular_function	ATP hydrolysis activity
5B	0030532	cellular_component	small nuclear ribonucleoprotein complex
5B	0042802	molecular_function	identical protein binding
5B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5B	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
5B	0071005	cellular_component	U2-type precatalytic spliceosome
5B	0071006	cellular_component	U2-type catalytic step 1 spliceosome
5B	0071013	cellular_component	catalytic step 2 spliceosome
5C	0003924	molecular_function	GTPase activity
5C	0005525	molecular_function	GTP binding
5D	0000245	biological_process	spliceosomal complex assembly
5D	0000375	biological_process	RNA splicing, via transesterification reactions
5D	0000387	biological_process	spliceosomal snRNP assembly
5D	0000398	biological_process	mRNA splicing, via spliceosome
5D	0005515	molecular_function	protein binding
5D	0005634	cellular_component	nucleus
5D	0005654	cellular_component	nucleoplasm
5D	0005681	cellular_component	spliceosomal complex
5D	0005682	cellular_component	U5 snRNP
5D	0006397	biological_process	mRNA processing
5D	0008380	biological_process	RNA splicing
5D	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5D	0051301	biological_process	cell division
5D	0071005	cellular_component	U2-type precatalytic spliceosome
5J	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5J	0000245	biological_process	spliceosomal complex assembly
5J	0000375	biological_process	RNA splicing, via transesterification reactions
5J	0000387	biological_process	spliceosomal snRNP assembly
5J	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5J	0000398	biological_process	mRNA splicing, via spliceosome
5J	0003723	molecular_function	RNA binding
5J	0005515	molecular_function	protein binding
5J	0005634	cellular_component	nucleus
5J	0005654	cellular_component	nucleoplasm
5J	0005681	cellular_component	spliceosomal complex
5J	0005682	cellular_component	U5 snRNP
5J	0006396	biological_process	RNA processing
5J	0006397	biological_process	mRNA processing
5J	0006403	biological_process	RNA localization
5J	0008380	biological_process	RNA splicing
5J	0016020	cellular_component	membrane
5J	0016607	cellular_component	nuclear speck
5J	0030674	molecular_function	protein-macromolecule adaptor activity
5J	0042802	molecular_function	identical protein binding
5J	0043021	molecular_function	ribonucleoprotein complex binding
5J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
5J	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5J	0071005	cellular_component	U2-type precatalytic spliceosome
5J	0071013	cellular_component	catalytic step 2 spliceosome
5O	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5O	0000375	biological_process	RNA splicing, via transesterification reactions
5O	0000387	biological_process	spliceosomal snRNP assembly
5O	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5O	0000398	biological_process	mRNA splicing, via spliceosome
5O	0003723	molecular_function	RNA binding
5O	0005515	molecular_function	protein binding
5O	0005634	cellular_component	nucleus
5O	0005654	cellular_component	nucleoplasm
5O	0005681	cellular_component	spliceosomal complex
5O	0005682	cellular_component	U5 snRNP
5O	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
5O	0006396	biological_process	RNA processing
5O	0006397	biological_process	mRNA processing
5O	0008380	biological_process	RNA splicing
5O	0016607	cellular_component	nuclear speck
5O	0071007	cellular_component	U2-type catalytic step 2 spliceosome
5O	0071013	cellular_component	catalytic step 2 spliceosome
5X	0000166	molecular_function	nucleotide binding
5X	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5X	0000354	biological_process	cis assembly of pre-catalytic spliceosome
5X	0000375	biological_process	RNA splicing, via transesterification reactions
5X	0000387	biological_process	spliceosomal snRNP assembly
5X	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5X	0000398	biological_process	mRNA splicing, via spliceosome
5X	0000785	cellular_component	chromatin
5X	0003676	molecular_function	nucleic acid binding
5X	0003723	molecular_function	RNA binding
5X	0003724	molecular_function	RNA helicase activity
5X	0003729	molecular_function	mRNA binding
5X	0004386	molecular_function	helicase activity
5X	0005515	molecular_function	protein binding
5X	0005524	molecular_function	ATP binding
5X	0005634	cellular_component	nucleus
5X	0005654	cellular_component	nucleoplasm
5X	0005681	cellular_component	spliceosomal complex
5X	0005682	cellular_component	U5 snRNP
5X	0005694	cellular_component	chromosome
5X	0005730	cellular_component	nucleolus
5X	0006397	biological_process	mRNA processing
5X	0008380	biological_process	RNA splicing
5X	0016787	molecular_function	hydrolase activity
5X	0016887	molecular_function	ATP hydrolysis activity
5X	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5X	0062176	biological_process	R-loop processing
5X	0070062	cellular_component	extracellular exosome
5X	0071013	cellular_component	catalytic step 2 spliceosome
5b	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5b	0000245	biological_process	spliceosomal complex assembly
5b	0000387	biological_process	spliceosomal snRNP assembly
5b	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5b	0000398	biological_process	mRNA splicing, via spliceosome
5b	0003723	molecular_function	RNA binding
5b	0005515	molecular_function	protein binding
5b	0005634	cellular_component	nucleus
5b	0005654	cellular_component	nucleoplasm
5b	0005681	cellular_component	spliceosomal complex
5b	0005682	cellular_component	U5 snRNP
5b	0005683	cellular_component	U7 snRNP
5b	0005684	cellular_component	U2-type spliceosomal complex
5b	0005685	cellular_component	U1 snRNP
5b	0005686	cellular_component	U2 snRNP
5b	0005687	cellular_component	U4 snRNP
5b	0005689	cellular_component	U12-type spliceosomal complex
5b	0005697	cellular_component	telomerase holoenzyme complex
5b	0005737	cellular_component	cytoplasm
5b	0005829	cellular_component	cytosol
5b	0006397	biological_process	mRNA processing
5b	0006479	biological_process	protein methylation
5b	0008380	biological_process	RNA splicing
5b	0030532	cellular_component	small nuclear ribonucleoprotein complex
5b	0034709	cellular_component	methylosome
5b	0034719	cellular_component	SMN-Sm protein complex
5b	0036261	biological_process	7-methylguanosine cap hypermethylation
5b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5b	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
5b	0070034	molecular_function	telomerase RNA binding
5b	0070990	molecular_function	snRNP binding
5b	0071004	cellular_component	U2-type prespliceosome
5b	0071005	cellular_component	U2-type precatalytic spliceosome
5b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
5b	0071013	cellular_component	catalytic step 2 spliceosome
5b	0071045	biological_process	nuclear histone mRNA catabolic process
5b	0071204	cellular_component	histone pre-mRNA 3'end processing complex
5b	0071208	molecular_function	histone pre-mRNA DCP binding
5b	1903241	biological_process	U2-type prespliceosome assembly
5b	1990446	molecular_function	U1 snRNP binding
5b	1990447	molecular_function	U2 snRNP binding
5b	1990904	cellular_component	ribonucleoprotein complex
5e	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5e	0000245	biological_process	spliceosomal complex assembly
5e	0000387	biological_process	spliceosomal snRNP assembly
5e	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5e	0000398	biological_process	mRNA splicing, via spliceosome
5e	0003723	molecular_function	RNA binding
5e	0005515	molecular_function	protein binding
5e	0005634	cellular_component	nucleus
5e	0005654	cellular_component	nucleoplasm
5e	0005681	cellular_component	spliceosomal complex
5e	0005682	cellular_component	U5 snRNP
5e	0005683	cellular_component	U7 snRNP
5e	0005684	cellular_component	U2-type spliceosomal complex
5e	0005685	cellular_component	U1 snRNP
5e	0005686	cellular_component	U2 snRNP
5e	0005687	cellular_component	U4 snRNP
5e	0005689	cellular_component	U12-type spliceosomal complex
5e	0005697	cellular_component	telomerase holoenzyme complex
5e	0005829	cellular_component	cytosol
5e	0006397	biological_process	mRNA processing
5e	0008380	biological_process	RNA splicing
5e	0030532	cellular_component	small nuclear ribonucleoprotein complex
5e	0034709	cellular_component	methylosome
5e	0034715	cellular_component	pICln-Sm protein complex
5e	0034719	cellular_component	SMN-Sm protein complex
5e	0036261	biological_process	7-methylguanosine cap hypermethylation
5e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5e	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
5e	0071005	cellular_component	U2-type precatalytic spliceosome
5e	0071007	cellular_component	U2-type catalytic step 2 spliceosome
5e	0071011	cellular_component	precatalytic spliceosome
5e	0071013	cellular_component	catalytic step 2 spliceosome
5e	0071045	biological_process	nuclear histone mRNA catabolic process
5e	1903241	biological_process	U2-type prespliceosome assembly
5e	1990904	cellular_component	ribonucleoprotein complex
5f	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5f	0000245	biological_process	spliceosomal complex assembly
5f	0000387	biological_process	spliceosomal snRNP assembly
5f	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5f	0000398	biological_process	mRNA splicing, via spliceosome
5f	0003723	molecular_function	RNA binding
5f	0005515	molecular_function	protein binding
5f	0005634	cellular_component	nucleus
5f	0005654	cellular_component	nucleoplasm
5f	0005681	cellular_component	spliceosomal complex
5f	0005683	cellular_component	U7 snRNP
5f	0005684	cellular_component	U2-type spliceosomal complex
5f	0005685	cellular_component	U1 snRNP
5f	0005687	cellular_component	U4 snRNP
5f	0005689	cellular_component	U12-type spliceosomal complex
5f	0005829	cellular_component	cytosol
5f	0006397	biological_process	mRNA processing
5f	0008380	biological_process	RNA splicing
5f	0022618	biological_process	protein-RNA complex assembly
5f	0030532	cellular_component	small nuclear ribonucleoprotein complex
5f	0034709	cellular_component	methylosome
5f	0034715	cellular_component	pICln-Sm protein complex
5f	0034719	cellular_component	SMN-Sm protein complex
5f	0036261	biological_process	7-methylguanosine cap hypermethylation
5f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5f	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
5f	0071005	cellular_component	U2-type precatalytic spliceosome
5f	0071007	cellular_component	U2-type catalytic step 2 spliceosome
5f	0071013	cellular_component	catalytic step 2 spliceosome
5f	0071045	biological_process	nuclear histone mRNA catabolic process
5f	1903241	biological_process	U2-type prespliceosome assembly
5f	1990904	cellular_component	ribonucleoprotein complex
5g	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5g	0000245	biological_process	spliceosomal complex assembly
5g	0000387	biological_process	spliceosomal snRNP assembly
5g	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5g	0000398	biological_process	mRNA splicing, via spliceosome
5g	0003723	molecular_function	RNA binding
5g	0005515	molecular_function	protein binding
5g	0005634	cellular_component	nucleus
5g	0005654	cellular_component	nucleoplasm
5g	0005681	cellular_component	spliceosomal complex
5g	0005682	cellular_component	U5 snRNP
5g	0005683	cellular_component	U7 snRNP
5g	0005684	cellular_component	U2-type spliceosomal complex
5g	0005685	cellular_component	U1 snRNP
5g	0005686	cellular_component	U2 snRNP
5g	0005687	cellular_component	U4 snRNP
5g	0005689	cellular_component	U12-type spliceosomal complex
5g	0005829	cellular_component	cytosol
5g	0006397	biological_process	mRNA processing
5g	0008380	biological_process	RNA splicing
5g	0030532	cellular_component	small nuclear ribonucleoprotein complex
5g	0034709	cellular_component	methylosome
5g	0034719	cellular_component	SMN-Sm protein complex
5g	0036261	biological_process	7-methylguanosine cap hypermethylation
5g	0043186	cellular_component	P granule
5g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5g	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
5g	0071004	cellular_component	U2-type prespliceosome
5g	0071005	cellular_component	U2-type precatalytic spliceosome
5g	0071007	cellular_component	U2-type catalytic step 2 spliceosome
5g	0071011	cellular_component	precatalytic spliceosome
5g	0071013	cellular_component	catalytic step 2 spliceosome
5g	0071045	biological_process	nuclear histone mRNA catabolic process
5g	0097526	cellular_component	spliceosomal tri-snRNP complex
5g	1903241	biological_process	U2-type prespliceosome assembly
5g	1990904	cellular_component	ribonucleoprotein complex
62	0000244	biological_process	spliceosomal tri-snRNP complex assembly
62	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
62	0000387	biological_process	spliceosomal snRNP assembly
62	0000398	biological_process	mRNA splicing, via spliceosome
62	0000932	cellular_component	P-body
62	0003723	molecular_function	RNA binding
62	0005634	cellular_component	nucleus
62	0005654	cellular_component	nucleoplasm
62	0005681	cellular_component	spliceosomal complex
62	0005688	cellular_component	U6 snRNP
62	0005737	cellular_component	cytoplasm
62	0005829	cellular_component	cytosol
62	0006397	biological_process	mRNA processing
62	0006402	biological_process	mRNA catabolic process
62	0008380	biological_process	RNA splicing
62	0017070	molecular_function	U6 snRNA binding
62	0031267	molecular_function	small GTPase binding
62	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
62	0071005	cellular_component	U2-type precatalytic spliceosome
62	0071011	cellular_component	precatalytic spliceosome
62	0071013	cellular_component	catalytic step 2 spliceosome
62	0120115	cellular_component	Lsm2-8 complex
62	1990726	cellular_component	Lsm1-7-Pat1 complex
62	1990904	cellular_component	ribonucleoprotein complex
63	0000244	biological_process	spliceosomal tri-snRNP complex assembly
63	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
63	0000387	biological_process	spliceosomal snRNP assembly
63	0000398	biological_process	mRNA splicing, via spliceosome
63	0000932	cellular_component	P-body
63	0003723	molecular_function	RNA binding
63	0005515	molecular_function	protein binding
63	0005634	cellular_component	nucleus
63	0005654	cellular_component	nucleoplasm
63	0005681	cellular_component	spliceosomal complex
63	0005688	cellular_component	U6 snRNP
63	0005737	cellular_component	cytoplasm
63	0005829	cellular_component	cytosol
63	0006397	biological_process	mRNA processing
63	0008380	biological_process	RNA splicing
63	0030629	molecular_function	U6 snRNA 3'-end binding
63	0033962	biological_process	P-body assembly
63	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
63	0071005	cellular_component	U2-type precatalytic spliceosome
63	0071011	cellular_component	precatalytic spliceosome
63	0071013	cellular_component	catalytic step 2 spliceosome
63	0120115	cellular_component	Lsm2-8 complex
63	1990726	cellular_component	Lsm1-7-Pat1 complex
63	1990904	cellular_component	ribonucleoprotein complex
64	0000244	biological_process	spliceosomal tri-snRNP complex assembly
64	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
64	0000387	biological_process	spliceosomal snRNP assembly
64	0000398	biological_process	mRNA splicing, via spliceosome
64	0000932	cellular_component	P-body
64	0000956	biological_process	nuclear-transcribed mRNA catabolic process
64	0003723	molecular_function	RNA binding
64	0005515	molecular_function	protein binding
64	0005634	cellular_component	nucleus
64	0005654	cellular_component	nucleoplasm
64	0005681	cellular_component	spliceosomal complex
64	0005688	cellular_component	U6 snRNP
64	0005737	cellular_component	cytoplasm
64	0005829	cellular_component	cytosol
64	0006396	biological_process	RNA processing
64	0006397	biological_process	mRNA processing
64	0008380	biological_process	RNA splicing
64	0016020	cellular_component	membrane
64	0017070	molecular_function	U6 snRNA binding
64	0032991	cellular_component	protein-containing complex
64	0033962	biological_process	P-body assembly
64	0042731	molecular_function	PH domain binding
64	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
64	0071005	cellular_component	U2-type precatalytic spliceosome
64	0097526	cellular_component	spliceosomal tri-snRNP complex
64	0120115	cellular_component	Lsm2-8 complex
64	1990904	cellular_component	ribonucleoprotein complex
65	0000244	biological_process	spliceosomal tri-snRNP complex assembly
65	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
65	0000387	biological_process	spliceosomal snRNP assembly
65	0000398	biological_process	mRNA splicing, via spliceosome
65	0003723	molecular_function	RNA binding
65	0005634	cellular_component	nucleus
65	0005654	cellular_component	nucleoplasm
65	0005681	cellular_component	spliceosomal complex
65	0005688	cellular_component	U6 snRNP
65	0005737	cellular_component	cytoplasm
65	0005829	cellular_component	cytosol
65	0006397	biological_process	mRNA processing
65	0006402	biological_process	mRNA catabolic process
65	0008380	biological_process	RNA splicing
65	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
65	0046982	molecular_function	protein heterodimerization activity
65	0071005	cellular_component	U2-type precatalytic spliceosome
65	0120115	cellular_component	Lsm2-8 complex
65	1990726	cellular_component	Lsm1-7-Pat1 complex
65	1990904	cellular_component	ribonucleoprotein complex
66	0000244	biological_process	spliceosomal tri-snRNP complex assembly
66	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
66	0000387	biological_process	spliceosomal snRNP assembly
66	0000398	biological_process	mRNA splicing, via spliceosome
66	0000932	cellular_component	P-body
66	0003723	molecular_function	RNA binding
66	0005515	molecular_function	protein binding
66	0005634	cellular_component	nucleus
66	0005654	cellular_component	nucleoplasm
66	0005681	cellular_component	spliceosomal complex
66	0005688	cellular_component	U6 snRNP
66	0005730	cellular_component	nucleolus
66	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
66	0005737	cellular_component	cytoplasm
66	0005829	cellular_component	cytosol
66	0006364	biological_process	rRNA processing
66	0006397	biological_process	mRNA processing
66	0006402	biological_process	mRNA catabolic process
66	0008033	biological_process	tRNA processing
66	0008380	biological_process	RNA splicing
66	0030490	biological_process	maturation of SSU-rRNA
66	0030532	cellular_component	small nuclear ribonucleoprotein complex
66	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
66	0046982	molecular_function	protein heterodimerization activity
66	0071005	cellular_component	U2-type precatalytic spliceosome
66	0120115	cellular_component	Lsm2-8 complex
66	1990904	cellular_component	ribonucleoprotein complex
67	0000244	biological_process	spliceosomal tri-snRNP complex assembly
67	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
67	0000387	biological_process	spliceosomal snRNP assembly
67	0000398	biological_process	mRNA splicing, via spliceosome
67	0000956	biological_process	nuclear-transcribed mRNA catabolic process
67	0003723	molecular_function	RNA binding
67	0005515	molecular_function	protein binding
67	0005634	cellular_component	nucleus
67	0005654	cellular_component	nucleoplasm
67	0005681	cellular_component	spliceosomal complex
67	0005688	cellular_component	U6 snRNP
67	0005689	cellular_component	U12-type spliceosomal complex
67	0005737	cellular_component	cytoplasm
67	0005829	cellular_component	cytosol
67	0006397	biological_process	mRNA processing
67	0008380	biological_process	RNA splicing
67	0017070	molecular_function	U6 snRNA binding
67	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
67	0071004	cellular_component	U2-type prespliceosome
67	0071005	cellular_component	U2-type precatalytic spliceosome
67	0071013	cellular_component	catalytic step 2 spliceosome
67	0097526	cellular_component	spliceosomal tri-snRNP complex
67	0120115	cellular_component	Lsm2-8 complex
67	1990726	cellular_component	Lsm1-7-Pat1 complex
67	1990904	cellular_component	ribonucleoprotein complex
68	0000244	biological_process	spliceosomal tri-snRNP complex assembly
68	0000387	biological_process	spliceosomal snRNP assembly
68	0000398	biological_process	mRNA splicing, via spliceosome
68	0003723	molecular_function	RNA binding
68	0003729	molecular_function	mRNA binding
68	0005515	molecular_function	protein binding
68	0005634	cellular_component	nucleus
68	0005654	cellular_component	nucleoplasm
68	0005681	cellular_component	spliceosomal complex
68	0005688	cellular_component	U6 snRNP
68	0006397	biological_process	mRNA processing
68	0008380	biological_process	RNA splicing
68	0017070	molecular_function	U6 snRNA binding
68	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
68	0071005	cellular_component	U2-type precatalytic spliceosome
68	0071011	cellular_component	precatalytic spliceosome
68	0120115	cellular_component	Lsm2-8 complex
68	1990904	cellular_component	ribonucleoprotein complex
A1	0003723	molecular_function	RNA binding
A1	0006396	biological_process	RNA processing
A1	0045292	biological_process	mRNA cis splicing, via spliceosome
A2	0003676	molecular_function	nucleic acid binding
A2	0005634	cellular_component	nucleus
A2	0008270	molecular_function	zinc ion binding
A3	0000375	biological_process	RNA splicing, via transesterification reactions
A3	0000387	biological_process	spliceosomal snRNP assembly
A3	0000389	biological_process	mRNA 3'-splice site recognition
A3	0000398	biological_process	mRNA splicing, via spliceosome
A3	0003676	molecular_function	nucleic acid binding
A3	0003723	molecular_function	RNA binding
A3	0005515	molecular_function	protein binding
A3	0005634	cellular_component	nucleus
A3	0005654	cellular_component	nucleoplasm
A3	0005681	cellular_component	spliceosomal complex
A3	0005684	cellular_component	U2-type spliceosomal complex
A3	0005686	cellular_component	U2 snRNP
A3	0006397	biological_process	mRNA processing
A3	0008270	molecular_function	zinc ion binding
A3	0008380	biological_process	RNA splicing
A3	0016607	cellular_component	nuclear speck
A3	0046872	molecular_function	metal ion binding
A3	0071005	cellular_component	U2-type precatalytic spliceosome
A3	0071013	cellular_component	catalytic step 2 spliceosome
A3	1903241	biological_process	U2-type prespliceosome assembly
B1	0000245	biological_process	spliceosomal complex assembly
B1	0000375	biological_process	RNA splicing, via transesterification reactions
B1	0000387	biological_process	spliceosomal snRNP assembly
B1	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B1	0000398	biological_process	mRNA splicing, via spliceosome
B1	0000785	cellular_component	chromatin
B1	0003723	molecular_function	RNA binding
B1	0003729	molecular_function	mRNA binding
B1	0005515	molecular_function	protein binding
B1	0005634	cellular_component	nucleus
B1	0005654	cellular_component	nucleoplasm
B1	0005681	cellular_component	spliceosomal complex
B1	0005684	cellular_component	U2-type spliceosomal complex
B1	0005686	cellular_component	U2 snRNP
B1	0005689	cellular_component	U12-type spliceosomal complex
B1	0005730	cellular_component	nucleolus
B1	0006338	biological_process	chromatin remodeling
B1	0006397	biological_process	mRNA processing
B1	0008380	biological_process	RNA splicing
B1	0016607	cellular_component	nuclear speck
B1	0031981	cellular_component	nuclear lumen
B1	0034693	cellular_component	U11/U12 snRNP
B1	0036002	molecular_function	pre-mRNA binding
B1	0045943	biological_process	positive regulation of transcription by RNA polymerase I
B1	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B1	0045945	biological_process	positive regulation of transcription by RNA polymerase III
B1	0071004	cellular_component	U2-type prespliceosome
B1	0071005	cellular_component	U2-type precatalytic spliceosome
B1	0071013	cellular_component	catalytic step 2 spliceosome
B1	1903241	biological_process	U2-type prespliceosome assembly
B1	1990935	molecular_function	splicing factor binding
B2	0000387	biological_process	spliceosomal snRNP assembly
B2	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B2	0000398	biological_process	mRNA splicing, via spliceosome
B2	0003723	molecular_function	RNA binding
B2	0005515	molecular_function	protein binding
B2	0005634	cellular_component	nucleus
B2	0005654	cellular_component	nucleoplasm
B2	0005681	cellular_component	spliceosomal complex
B2	0005684	cellular_component	U2-type spliceosomal complex
B2	0005686	cellular_component	U2 snRNP
B2	0005689	cellular_component	U12-type spliceosomal complex
B2	0006397	biological_process	mRNA processing
B2	0008380	biological_process	RNA splicing
B2	0016607	cellular_component	nuclear speck
B2	0071005	cellular_component	U2-type precatalytic spliceosome
B2	0071011	cellular_component	precatalytic spliceosome
B2	0071013	cellular_component	catalytic step 2 spliceosome
B2	1903241	biological_process	U2-type prespliceosome assembly
B3	0000375	biological_process	RNA splicing, via transesterification reactions
B3	0000387	biological_process	spliceosomal snRNP assembly
B3	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B3	0000398	biological_process	mRNA splicing, via spliceosome
B3	0003676	molecular_function	nucleic acid binding
B3	0005515	molecular_function	protein binding
B3	0005634	cellular_component	nucleus
B3	0005654	cellular_component	nucleoplasm
B3	0005681	cellular_component	spliceosomal complex
B3	0005684	cellular_component	U2-type spliceosomal complex
B3	0005686	cellular_component	U2 snRNP
B3	0005689	cellular_component	U12-type spliceosomal complex
B3	0005730	cellular_component	nucleolus
B3	0006282	biological_process	regulation of DNA repair
B3	0006397	biological_process	mRNA processing
B3	0008380	biological_process	RNA splicing
B3	0030620	molecular_function	U2 snRNA binding
B3	0042177	biological_process	negative regulation of protein catabolic process
B3	0043484	biological_process	regulation of RNA splicing
B3	0044877	molecular_function	protein-containing complex binding
B3	0045893	biological_process	positive regulation of DNA-templated transcription
B3	0071005	cellular_component	U2-type precatalytic spliceosome
B3	0071013	cellular_component	catalytic step 2 spliceosome
B3	1903241	biological_process	U2-type prespliceosome assembly
B4	0000375	biological_process	RNA splicing, via transesterification reactions
B4	0000387	biological_process	spliceosomal snRNP assembly
B4	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B4	0000398	biological_process	mRNA splicing, via spliceosome
B4	0003676	molecular_function	nucleic acid binding
B4	0003723	molecular_function	RNA binding
B4	0005515	molecular_function	protein binding
B4	0005634	cellular_component	nucleus
B4	0005654	cellular_component	nucleoplasm
B4	0005681	cellular_component	spliceosomal complex
B4	0005684	cellular_component	U2-type spliceosomal complex
B4	0005686	cellular_component	U2 snRNP
B4	0005689	cellular_component	U12-type spliceosomal complex
B4	0006397	biological_process	mRNA processing
B4	0008380	biological_process	RNA splicing
B4	0071005	cellular_component	U2-type precatalytic spliceosome
B4	0071011	cellular_component	precatalytic spliceosome
B4	1903241	biological_process	U2-type prespliceosome assembly
B4	1990935	molecular_function	splicing factor binding
B5	0000387	biological_process	spliceosomal snRNP assembly
B5	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B5	0000398	biological_process	mRNA splicing, via spliceosome
B5	0003723	molecular_function	RNA binding
B5	0005515	molecular_function	protein binding
B5	0005634	cellular_component	nucleus
B5	0005654	cellular_component	nucleoplasm
B5	0005681	cellular_component	spliceosomal complex
B5	0005684	cellular_component	U2-type spliceosomal complex
B5	0005686	cellular_component	U2 snRNP
B5	0005689	cellular_component	U12-type spliceosomal complex
B5	0006282	biological_process	regulation of DNA repair
B5	0006397	biological_process	mRNA processing
B5	0008380	biological_process	RNA splicing
B5	0043484	biological_process	regulation of RNA splicing
B5	0045893	biological_process	positive regulation of DNA-templated transcription
B5	0071005	cellular_component	U2-type precatalytic spliceosome
B5	0071011	cellular_component	precatalytic spliceosome
B5	1903241	biological_process	U2-type prespliceosome assembly
B5	1990935	molecular_function	splicing factor binding
BP	0000387	biological_process	spliceosomal snRNP assembly
BP	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
BP	0000398	biological_process	mRNA splicing, via spliceosome
BP	0003677	molecular_function	DNA binding
BP	0003723	molecular_function	RNA binding
BP	0005515	molecular_function	protein binding
BP	0005634	cellular_component	nucleus
BP	0005654	cellular_component	nucleoplasm
BP	0005681	cellular_component	spliceosomal complex
BP	0005684	cellular_component	U2-type spliceosomal complex
BP	0005686	cellular_component	U2 snRNP
BP	0005689	cellular_component	U12-type spliceosomal complex
BP	0006351	biological_process	DNA-templated transcription
BP	0006397	biological_process	mRNA processing
BP	0008270	molecular_function	zinc ion binding
BP	0008380	biological_process	RNA splicing
BP	0016363	cellular_component	nuclear matrix
BP	0016607	cellular_component	nuclear speck
BP	0045893	biological_process	positive regulation of DNA-templated transcription
BP	0046872	molecular_function	metal ion binding
BP	0048863	biological_process	stem cell differentiation
BP	0071005	cellular_component	U2-type precatalytic spliceosome
BP	0071011	cellular_component	precatalytic spliceosome
BP	1903241	biological_process	U2-type prespliceosome assembly
K	0000166	molecular_function	nucleotide binding
K	0000244	biological_process	spliceosomal tri-snRNP complex assembly
K	0000387	biological_process	spliceosomal snRNP assembly
K	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0000776	cellular_component	kinetochore
K	0003723	molecular_function	RNA binding
K	0004672	molecular_function	protein kinase activity
K	0004674	molecular_function	protein serine/threonine kinase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005681	cellular_component	spliceosomal complex
K	0005694	cellular_component	chromosome
K	0006397	biological_process	mRNA processing
K	0006468	biological_process	protein phosphorylation
K	0008380	biological_process	RNA splicing
K	0016301	molecular_function	kinase activity
K	0016607	cellular_component	nuclear speck
K	0016740	molecular_function	transferase activity
K	0035332	biological_process	positive regulation of hippo signaling
K	0045292	biological_process	mRNA cis splicing, via spliceosome
K	0046827	biological_process	positive regulation of protein export from nucleus
K	0071013	cellular_component	catalytic step 2 spliceosome
K	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
K	0106310	molecular_function	protein serine kinase activity
R	0000387	biological_process	spliceosomal snRNP assembly
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0003676	molecular_function	nucleic acid binding
R	0003723	molecular_function	RNA binding
R	0003729	molecular_function	mRNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
S	0000244	biological_process	spliceosomal tri-snRNP complex assembly
S	0000387	biological_process	spliceosomal snRNP assembly
S	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0000481	biological_process	maturation of 5S rRNA
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005681	cellular_component	spliceosomal complex
S	0005737	cellular_component	cytoplasm
S	0005794	cellular_component	Golgi apparatus
S	0005829	cellular_component	cytosol
S	0006397	biological_process	mRNA processing
S	0008380	biological_process	RNA splicing
S	0015030	cellular_component	Cajal body
S	0016607	cellular_component	nuclear speck
S	0045292	biological_process	mRNA cis splicing, via spliceosome
S	0045585	biological_process	positive regulation of cytotoxic T cell differentiation
S	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
S	0071005	cellular_component	U2-type precatalytic spliceosome
S	0071013	cellular_component	catalytic step 2 spliceosome
U	0000244	biological_process	spliceosomal tri-snRNP complex assembly
U	0000245	biological_process	spliceosomal complex assembly
U	0000387	biological_process	spliceosomal snRNP assembly
U	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
U	0000398	biological_process	mRNA splicing, via spliceosome
U	0004843	molecular_function	cysteine-type deubiquitinase activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005681	cellular_component	spliceosomal complex
U	0006397	biological_process	mRNA processing
U	0008270	molecular_function	zinc ion binding
U	0008380	biological_process	RNA splicing
U	0016579	biological_process	protein deubiquitination
U	0016787	molecular_function	hydrolase activity
U	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
U	0046872	molecular_function	metal ion binding
U	0051301	biological_process	cell division
X	0000387	biological_process	spliceosomal snRNP assembly
X	0000398	biological_process	mRNA splicing, via spliceosome
X	0003676	molecular_function	nucleic acid binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0006397	biological_process	mRNA processing
X	0008380	biological_process	RNA splicing

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A2 500

Chain	Residue
A2	CYS56
A2	CYS59
A2	HIS72
A2	HIS78

---

site_id	AC2
Number of Residues	3
Details	binding site for residue MG 5C 1001

Chain	Residue
5C	THR143
5C	ASP204
5C	GTP1002

---

site_id	AC3
Number of Residues	23
Details	binding site for residue GTP 5C 1002

Chain	Residue
5C	HIS139
5C	HIS140
5C	GLY141
5C	LYS142
5C	THR143
5C	CYS144
5C	ASP164
5C	GLY178
5C	VAL179
5C	GLY180
5C	GLY207
5C	HIS208
5C	ASN258
5C	LYS259
5C	ASP261
5C	ARG262
5C	GLU266
5C	SER311
5C	SER312
5C	GLN313
5C	MG1001
5A	PRO335
5C	LEU138

---

site_id	AC4
Number of Residues	12
Details	binding site for residue IHP 5A 2401

Chain	Residue
5A	ARG163
5A	LYS442
5A	HIS584
5A	LYS606
5A	LYS609
5A	HIS610
5A	TYR613
5A	TYR614
5A	ASN617
5A	LYS623
5A	GLY624
5X	GLU275

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN U 601

Chain	Residue
U	CYS136
U	CYS139
U	HIS155
U	HIS161

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN BP 201

Chain	Residue
BP	CYS11
BP	CYS46
BP	CYS49
BP	CYS85

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN BP 202

Chain	Residue
BP	CYS23
BP	CYS26
BP	CYS58
BP	CYS61

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN BP 203

Chain	Residue
BP	CYS30
BP	CYS33
BP	CYS72
BP	CYS75

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN 1C 201

Chain	Residue
1C	CYS6
1C	CYS9
1C	HIS24
1C	HIS30

---

site_id	AD1
Number of Residues	8
Details	binding site for Ligand GLY A3 353 bound to THR 21 78

Chain	Residue
21	PRO75
21	ASP77
21	THR78
A3	THR352
A3	GLU354
A3	GLU355
A3	ARG356
A3	GLU357

---

site_id	AD2
Number of Residues	7
Details	binding site for Ligand GLU A3 354 bound to THR 21 78

Chain	Residue
21	THR78
A3	THR352
A3	GLY353
A3	GLU355
A3	ARG356
A3	GLU357
A3	GLU358

---

site_id	AD3
Number of Residues	10
Details	binding site for Di-nucleotide M7M 4 0 and A 4 1

Chain	Residue
4	G2
4A	LYS526
4A	ILE530
4A	LEU533
4A	ASN563
4A	GLN566
4A	TYR568
6	U74
6	G75
6	A76

---

site_id	AD4
Number of Residues	15
Details	binding site for Di-peptide M7M 4 0 and LYS 4A 526

Chain	Residue
6	U74
6	G75
6	A76
4	A1
4A	GLU523
4A	GLN524
4A	ARG525
4A	VAL527
4A	LYS528
4A	LYS529
4A	ILE530
4A	LEU533
4A	ASN563
4A	GLN566
4A	TYR568

---

site_id	AD5
Number of Residues	8
Details	binding site for Di-peptide UNK A1 431 and GLN 4A 451

Chain	Residue
4A	LYS447
4A	LEU448
4A	ARG449
4A	ARG450
4A	THR452
4A	ARG453
4A	ARG454
4A	GLU455

---

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmI

Chain	Residue	Details
5X	VAL547-ILE555

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHaDIKpdNILV

Chain	Residue	Details
K	ILE811-VAL823

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH

Chain	Residue	Details
B3	PHE287-HIS293

---

site_id	PS00436
Number of Residues	12
Details	PEROXIDASE_2 Peroxidases active site signature. TVrvARVmWHPS

Chain	Residue	Details
4B	THR323-SER334

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LGTTcyDrSWRLWDL

Chain	Residue	Details
4B	LEU338-LEU352
4B	ILE422-LEU436
5O	LEU81-VAL95
5O	LEU124-SER138
5O	VAL167-ILE181
5O	ILE208-LEU222
5O	ILE300-THR314

---

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CedknVPYvfVrSKqaLG

Chain	Residue	Details
4D	CYS73-GLY90

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	78
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	86
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	79
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	78
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	78
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	79
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	63
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1013
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	156
Details	Domain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	61
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	110
Details	Region: {"description":"Required for interaction with U1 RNA","evidences":[{"source":"PubMed","id":"2467746","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	30
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	9
Details	Compositional bias: {"description":"Gly residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	10
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	34
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	13
Details	Motif: {"description":"Nuclear localization signal (NLS)","evidences":[{"source":"PubMed","id":"12444105","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Site: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	3
Details	Site: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Site: {"description":"Interaction with U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	79
Details	Region: {"description":"Sufficient for interaction with CLNS1A","evidences":[{"source":"PubMed","id":"11747828","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	158
Details	Domain: {"description":"RRM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	61
Details	Zinc finger: {"description":"Matrin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00130","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	Modified residue: {"description":"Symmetric dimethylarginine; by PRMT9; alternate","evidences":[{"source":"PubMed","id":"25737013","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	14
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	282
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	28
Details	Motif: {"description":"Q motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00552","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	3
Details	Motif: {"description":"DEAD box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	77
Details	Region: {"description":"Interaction with SF3B1 and SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	7
Details	Site: {"description":"Interaction with RNA","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	32
Details	Repeat: {"description":"HAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	26
Details	Repeat: {"description":"HAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	31
Details	Repeat: {"description":"HAT 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	32
Details	Repeat: {"description":"HAT 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	32
Details	Repeat: {"description":"HAT 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	32
Details	Repeat: {"description":"HAT 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	32
Details	Repeat: {"description":"HAT 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI51
Number of Residues	32
Details	Repeat: {"description":"HAT 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI52
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O94906","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI53
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O94906","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI54
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI55
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI56
Number of Residues	12
Details	Region: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21784869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI57
Number of Residues	32
Details	Region: {"description":"Important for U4 snRNA-binding","evidences":[{"source":"PubMed","id":"10545122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI58
Number of Residues	2
Details	Site: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21784869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI59
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D0T1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI60
Number of Residues	37
Details	Region: {"description":"Interaction with PHF5A, SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI61
Number of Residues	56
Details	Region: {"description":"Interaction with SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI62
Number of Residues	21
Details	Region: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI63
Number of Residues	23
Details	Region: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI64
Number of Residues	5
Details	Site: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI65
Number of Residues	2
Details	Site: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI66
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI67
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI68
Number of Residues	131
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI69
Number of Residues	491
Details	Region: {"description":"Reverse transcriptase homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI70
Number of Residues	13
Details	Region: {"description":"Important for branch point selection","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI71
Number of Residues	171
Details	Region: {"description":"Restriction endonuclease homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI72
Number of Residues	34
Details	Region: {"description":"Required for interaction with EFTUD2 and SNRNP200","evidences":[{"source":"PubMed","id":"17317632","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI73
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI74
Number of Residues	1
Details	Modified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI75
Number of Residues	4
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"21349847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI76
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2004","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI77
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI78
Number of Residues	330
Details	Domain: {"description":"USP"}

Chain

Residue

Details

---

site_id	SWS_FT_FI79
Number of Residues	97
Details	Zinc finger: {"description":"UBP-type; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00502","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI80
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00502","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI81
Number of Residues	3
Details	Region: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI82
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28541300","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IFE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SYB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI83
Number of Residues	4
Details	Site: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI84
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P83870","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI85
Number of Residues	32
Details	Zinc finger: {"description":"Matrin-type","evidences":[{"source":"HAMAP-Rule","id":"MF_03153","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI86
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI87
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI88
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI89
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI90
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q5RKH1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI91
Number of Residues	21
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI92
Number of Residues	21
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI93
Number of Residues	21
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI94
Number of Residues	21
Details	Repeat: {"description":"LRR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI95
Number of Residues	38
Details	Domain: {"description":"LRRCT"}

Chain

Residue

Details

---

site_id	SWS_FT_FI96
Number of Residues	42
Details	Repeat: {"description":"SURP motif 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI97
Number of Residues	1
Details	Site: {"description":"Critical for binding to SF3A3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI98
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI99
Number of Residues	183
Details	Domain: {"description":"Helicase ATP-binding 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI100
Number of Residues	237
Details	Domain: {"description":"Helicase C-terminal 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI101
Number of Residues	305
Details	Domain: {"description":"SEC63 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI102
Number of Residues	175
Details	Domain: {"description":"Helicase ATP-binding 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI103
Number of Residues	208
Details	Domain: {"description":"Helicase C-terminal 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI104
Number of Residues	312
Details	Domain: {"description":"SEC63 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI105
Number of Residues	30
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI106
Number of Residues	3
Details	Motif: {"description":"DEIH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI107
Number of Residues	3
Details	Motif: {"description":"DEVH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI108
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23045696","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F93","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI109
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"F1LNJ2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI110
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q6P4T2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI111
Number of Residues	39
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI112
Number of Residues	34
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI113
Number of Residues	37
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI114
Number of Residues	34
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI115
Number of Residues	38
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI116
Number of Residues	38
Details	Repeat: {"description":"HEAT 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI117
Number of Residues	38
Details	Repeat: {"description":"HEAT 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI118
Number of Residues	38
Details	Repeat: {"description":"HEAT 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI119
Number of Residues	38
Details	Repeat: {"description":"HEAT 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI120
Number of Residues	38
Details	Repeat: {"description":"HEAT 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI121
Number of Residues	38
Details	Repeat: {"description":"HEAT 11"}

Chain

Residue

Details

---

site_id	SWS_FT_FI122
Number of Residues	39
Details	Region: {"description":"Interaction with SF3B14"}

Chain

Residue

Details

---

site_id	SWS_FT_FI123
Number of Residues	4
Details	Region: {"description":"Interaction with PHF5A","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI124
Number of Residues	56
Details	Region: {"description":"Interaction with SF3B3 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI125
Number of Residues	1
Details	Site: {"description":"Interaction with PHF5A","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI126
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---