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PDB: 155 件
5WXS
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Crystal structure of uPA in complex with S2444
分子名称: (2R)-N-[2-[[(2S)-5-carbamimidamido-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-5-oxidanylidene-1,2-dihydropyrrole-2-carboxamide, Urokinase-type plasminogen activator chain B
著者Jiang, L, Huang, M.
登録日2017-01-08
公開日2018-07-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of uPA in complex with S2444
To Be Published
6NMB
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Tranexamic Acid is an Active Site Inhibitor of Urokinase Plasminogen Activator
分子名称: NITRATE ION, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID, Urokinase-type plasminogen activator
著者Law, R.H.P, Wu, G.
登録日2019-01-10
公開日2019-03-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Tranexamic acid is an active site inhibitor of urokinase plasminogen activator.
Blood Adv, 3, 2019
3PB1
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Crystal Structure of a Michaelis Complex between Plasminogen Activator Inhibitor-1 and Urokinase-type Plasminogen Activator
分子名称: Plasminogen activator inhibitor 1, Plasminogen activator, urokinase, ...
著者Lin, Z, Jiang, L, Huang, M, Structure 2 Function Project (S2F)
登録日2010-10-20
公開日2010-12-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1.
J.Biol.Chem., 286, 2011
3OY6
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The crystal structure of uPA complex with peptide inhibitor MH036 at pH4.6
分子名称: MH036, Urokinase-type plasminogen activator
著者Jiang, L.G, Andreasen, P.A, Huang, M.D.
登録日2010-09-22
公開日2011-08-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3OY5
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The crystal structure of uPA complex with peptide inhibitor MH027 at pH7.4
分子名称: MH027, SULFATE ION, Urokinase-type plasminogen activator
著者Jiang, L.G, Andreasen, P.A, Huang, M.D.
登録日2010-09-22
公開日2011-08-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
1OWD
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Substituted 2-Naphthamidine inhibitors of urokinase
分子名称: 6-[AMINO(IMINO)METHYL]-N-[(4R)-4-ETHYL-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL]-2-NAPHTHAMIDE, Urokinase-type plasminogen activator
著者Wendt, M.D, Rockway, T.W, Geyer, A, McClellan, W, Weitzberg, M, Zhao, X, Mantei, R, Nienaber, V.L, Stewart, K, Klinghofer, V, Giranda, V.L.
登録日2003-03-28
公開日2003-09-30
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution.
J.Med.Chem., 47, 2004
3KHV
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Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
分子名称: SULFATE ION, TRIETHYLENE GLYCOL, Urokinase-type plasminogen activator, ...
著者Jiang, L.-G, Zhao, G.-X, Bian, X.-B, Yuan, C, Huang, Z.-X, Huang, M.-D.
登録日2009-10-30
公開日2009-12-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
CHIN.J.STRUCT.CHEM., 28, 2009
3KGP
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Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
分子名称: 4-(aminomethyl)benzoic acid, SULFATE ION, Urokinase-type plasminogen activator
著者Jiang, L.-G, Zhao, G.-X, Bian, X.-B, Yuan, C, Huang, Z.-X, Huang, M.-D.
登録日2009-10-29
公開日2009-12-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
CHIN.J.STRUCT.CHEM., 28, 2009
1VJ9
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Urokinase Plasminogen Activator B-Chain-JT464 Complex
分子名称: N-(BENZYLSULFONYL)-L-SERYL-N~1~-{4-[AMINO(IMINO)METHYL]BENZYL}-O-BENZYL-L-SERINAMIDE, SULFATE ION, plasminogen activator, ...
著者Schweinitz, A, Steinmetzer, T, Banke, I.J, Arlt, M.J.E, Stuerzebecher, A, Schuster, O, Geissler, A, Giersiefen, H, Zeslawska, E, Jacob, U, Kruger, A, Stuerzebecher, J.
登録日2004-02-03
公開日2004-06-22
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents
J.Biol.Chem., 279, 2004
1SC8
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Urokinase Plasminogen Activator B-Chain-J435 Complex
分子名称: N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHYL]BENZYL}GLYCINAMIDE, SULFATE ION, plasminogen activator, ...
著者Schweinitz, A, Steinmetzer, T, Banke, I.J, Arlt, M.J.E, Stuerzebecher, A, Schuster, O, Geissler, A, Giersiefen, H, Zeslawska, E, Jacob, U, Kruger, A, Stuerzebecher, J.
登録日2004-02-12
公開日2004-06-22
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents
J.Biol.Chem., 279, 2004
1W12
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UROKINASE TYPE PLASMINOGEN ACTIVATOR
分子名称: N-((1S)-4-{[AMINO(IMINO)METHYL]AMINO}-1-FORMYLBUTYL)-2-{(3R)-3-[(BENZYLSULFONYL)AMINO]-2-OXO-5-PHENYL-2,3-DIHYDRO-1H-1,4-BENZODIAZEPIN-1-YL}ACETAMIDE, UROKINASE-TYPE PLASMINOGEN ACTIVATOR
著者Jacob, U.
登録日2004-06-15
公開日2008-05-20
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystals of Urokinase Type Plasminogen Activator Complexes Reveal the Binding Mode of Peptidomimetic Inhibitors.
J.Mol.Biol., 328, 2003
6AG3
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Crystal structure of uPA in complex with 3,5-bis(azanyl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide
分子名称: 3,5-bis(azanyl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Majed, H, Huang, M.D, Kelso, M, Ranson, M.
登録日2018-08-09
公開日2019-09-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献uPA-HMA
To Be Published
6L05
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Crystal structure of uPA_H99Y in complex with 50F
分子名称: 3-azanyl-5-(azepan-1-yl)-6-(1-benzofuran-2-yl)-Ncarbamimidoyl-pyrazine-2-carboxamide, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Huang, M.D, Kelso, M, Ranson, M.
登録日2019-09-26
公開日2020-09-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Crystal structure of uPA_H99Y in complex with 50F
To Be Published
3BT2
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Structure of urokinase receptor, urokinase and vitronectin complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, ...
著者Huang, M.
登録日2007-12-27
公開日2008-03-25
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Nat.Struct.Mol.Biol., 15, 2008
1LMW
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LMW U-PA Structure complexed with EGRCMK (GLU-GLY-ARG Chloromethyl Ketone)
分子名称: L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, UROKINASE-TYPE PLASMINOGEN ACTIVATOR
著者Spraggon, G.S, Phillips, C, Nowak, U.K, Ponting, C.P, Saunders, D, Dobson, C.M, Stuart, D.I, Jones, E.Y.
登録日1995-07-26
公開日1996-01-29
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structure of the catalytic domain of human urokinase-type plasminogen activator.
Structure, 3, 1995
1F92
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UROKINASE PLASMINOGEN ACTIVATOR B CHAIN-UKI-1D COMPLEX
分子名称: SULFATE ION, UROKINASE-TYPE PLASMINOGEN ACTIVATOR, [2,4,6-TRIISOPROPYL-PHENYLSULFONYL-L-[3-AMIDINO-PHENYLALANINYL]]-N'-BETA-ALANINYL-PIPERAZINE
著者Zeslawska, E, Schweinitz, A, Karcher, A, Sondermann, P, Sperl, S, Sturzebecher, J, Jacob, U.
登録日2000-07-06
公開日2001-07-06
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based drug design.
J.Mol.Biol., 301, 2000
3KID
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The Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator
分子名称: Urokinase-type plasminogen activator, ethyl 2-amino-1,3-benzothiazole-6-carboxylate
著者Jiang, L.-G, Yu, H.Y, Yuan, C, Wang, J.D, Chen, L.Q, Meehan, E.J, Huang, Z.-X, Huang, M.-D.
登録日2009-11-01
公開日2009-12-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator
CHIN.J.STRUCT.CHEM., 28, 2009
2I9B
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BU of 2i9b by Molmil
Crystal structure of ATF-urokinase receptor complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Urokinase plasminogen activator surface receptor, ...
著者Lubkowski, J, Barinka, C.
登録日2006-09-05
公開日2007-01-02
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis of interaction between urokinase-type plasminogen activator and its receptor.
J.Mol.Biol., 363, 2006
3BT1
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Structure of urokinase receptor, urokinase and vitronectin complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, Urokinase-type plasminogen activator, ...
著者Huang, M.
登録日2007-12-27
公開日2008-03-25
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Nat.Struct.Mol.Biol., 15, 2008
1OWK
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Substituted 2-Naphthamidine Inhibitors of Urokinase
分子名称: 6-[(Z)-AMINO(IMINO)METHYL]-N-(1-ISOPROPYL-1,2,3,4-TETRAHYDROISOQUINOLIN-7-YL)-2-NAPHTHAMIDE, Urokinase-type plasminogen activator
著者Wendt, M.D, Rockway, T.W, Geyer, A, McClellan, W, Weitzberg, M, Zhao, X, Mantei, R, Nienaber, V.L, Stewart, K, Klinghofer, V, Giranda, V.L.
登録日2003-03-28
公開日2003-09-30
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution.
J.Med.Chem., 47, 2004
1OWI
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Substituted 2-Naphthamidine Inhibitors of Urokinase
分子名称: 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE, Urokinase-type plasminogen activator
著者Wendt, M.D, Rockway, T.W, Geyer, A, McClellan, W, Weitzberg, M, Zhao, X, Mantei, R, Nienaber, V.L, Stewart, K, Klinghofer, V, Giranda, V.L.
登録日2003-03-28
公開日2003-09-30
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.93 Å)
主引用文献Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution.
J.Med.Chem., 47, 2004
4DW2
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The crystal structure of uPA in complex with the Fab fragment of mAb-112
分子名称: Fab fragment of pro-uPA antibody mAb-112, SULFATE ION, Urokinase-type plasminogen activator
著者Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M.
登録日2012-02-24
公開日2013-01-16
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Rezymogenation of active urokinase induced by an inhibitory antibody.
Biochem.J., 449, 2013
5ZAH
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uPA-BB2-30F
分子名称: 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2-methoxypyrimidin-5-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator chain B
著者Buckley, B.J, Jiang, L.G, Huang, M.D, Kelso, M.J, Ranson, M.
登録日2018-02-07
公開日2018-12-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5XG4
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Crystal structure of uPA in complex with quercetin
分子名称: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, Urokinase-type plasminogen activator
著者Jiang, L, Huang, M.
登録日2017-04-11
公開日2017-07-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A structural mechanism of flavonoids in inhibiting serine proteases
Food Funct, 8, 2017
1FV9
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Crystal structure of human microurokinase in complex with 2-amino-5-hydroxy-benzimidazole
分子名称: 2-AMINO-5-HYDROXY-BENZIMIDAZOLE, SULFATE ION, UROKINASE
著者Nienaber, V.
登録日2000-09-19
公開日2000-10-18
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Identification of novel inhibitors of urokinase via NMR-based screening.
J.Med.Chem., 43, 2000

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