9BBG
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![BU of 9bbg by Molmil](/molmil-images/mine/9bbg) | Co-crystal structure of human DDB1 bound to fragment UB028671 | 分子名称: | 1,2-ETHANEDIOL, 1H-indol-6-amine, DNA damage-binding protein 1, ... | 著者 | Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2024-04-05 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Co-crystal structure of human DDB1 bound to fragment UB028671 To be published
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9BBI
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![BU of 9bbi by Molmil](/molmil-images/mine/9bbi) | Co-crystal structure of human DDB1 bound to fragment UB028669 | 分子名称: | 3-([1,3]oxazolo[4,5-b]pyridin-2-yl)aniline, DNA damage-binding protein 1, L(+)-TARTARIC ACID, ... | 著者 | Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2024-04-05 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Co-crystal structure of human DDB1 bound to fragment UB028669 To be published
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9BBH
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![BU of 9bbh by Molmil](/molmil-images/mine/9bbh) | Co-crystal structure of human DDB1 bound to fragment UB028670 | 分子名称: | 1,2-ETHANEDIOL, 4-methoxy-1H-indole, DNA damage-binding protein 1, ... | 著者 | Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2024-04-05 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Co-crystal structure of human DDB1 bound to fragment UB028670 To be published
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9BBE
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![BU of 9bbe by Molmil](/molmil-images/mine/9bbe) | Co-crystal structure of human DDB1 bound to fragment UB028668 | 分子名称: | 5-(4-methoxyphenyl)-3-[(3S)-pyrrolidin-3-yl]-1,2,4-oxadiazole, DNA damage-binding protein 1, L(+)-TARTARIC ACID, ... | 著者 | Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2024-04-05 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Co-crystal structure of human DDB1 bound to fragment UB028668 To be published
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8G46
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![BU of 8g46 by Molmil](/molmil-images/mine/8g46) | Cryo-EM structure of DDB1deltaB-DDA1-DCAF16-BRD4(BD2)-MMH2 | 分子名称: | Bromodomain-containing protein 4, DDB1- and CUL4-associated factor 16, DET1- and DDB1-associated protein 1, ... | 著者 | Ma, M.W, Hunkeler, M, Jin, C.Y, Fischer, E.S. | 登録日 | 2023-02-08 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. Biorxiv, 2023
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6UD7
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![BU of 6ud7 by Molmil](/molmil-images/mine/6ud7) | Crystal structure of full-length human DCAF15-DDB1(deltaBPB)-DDA1-RBM39 in complex with indisulam | 分子名称: | DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1,DNA damage-binding protein 1, ... | 著者 | Bussiere, D.E, Shu, W, Xie, L, Knapp, M. | 登録日 | 2019-09-18 | 公開日 | 2019-12-18 | 最終更新日 | 2020-01-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nat.Chem.Biol., 16, 2020
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3EI3
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![BU of 3ei3 by Molmil](/molmil-images/mine/3ei3) | Structure of the hsDDB1-drDDB2 complex | 分子名称: | DNA damage-binding protein 1, DNA damage-binding protein 2, TETRAETHYLENE GLYCOL | 著者 | Scrima, A, Thoma, N.H. | 登録日 | 2008-09-15 | 公開日 | 2009-01-20 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. Cell(Cambridge,Mass.), 135, 2008
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8TNQ
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![BU of 8tnq by Molmil](/molmil-images/mine/8tnq) | Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 1 | 分子名称: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | 登録日 | 2023-08-02 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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3E0C
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![BU of 3e0c by Molmil](/molmil-images/mine/3e0c) | Crystal Structure of DNA Damage-Binding protein 1(DDB1) | 分子名称: | DNA damage-binding protein 1 | 著者 | Amaya, M.F, Xu, L, Hao, H, Bountra, C, Wickstroem, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2008-07-31 | 公開日 | 2008-09-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Structure and function of WD40 domain proteins. Protein Cell, 2, 2011
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5FQD
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![BU of 5fqd by Molmil](/molmil-images/mine/5fqd) | Structural basis of Lenalidomide induced CK1a degradation by the crl4crbn ubiquitin ligase | 分子名称: | CASEIN KINASE I ISOFORM ALPHA, DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, ... | 著者 | Petzold, G, Fischer, E.S, Thoma, N.H. | 登録日 | 2015-12-09 | 公開日 | 2016-02-24 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structural Basis of Lenalidomide-Induced Ck1Alpha Degradation by the Crl4(Crbn) Ubiquitin Ligase. Nature, 532, 2016
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8OIZ
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![BU of 8oiz by Molmil](/molmil-images/mine/8oiz) | Crystal structure of human CRBN-DDB1 in complex with Pomalidomide | 分子名称: | 1,2-ETHANEDIOL, DNA damage-binding protein 1, Protein cereblon, ... | 著者 | Le Bihan, Y.-V, Cabry, M.P, van Montfort, R.L.M. | 登録日 | 2023-03-23 | 公開日 | 2023-07-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A Degron Blocking Strategy Towards Improved CRL4 CRBN Recruiting PROTAC Selectivity. Chembiochem, 24, 2023
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8TNR
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![BU of 8tnr by Molmil](/molmil-images/mine/8tnr) | Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 2 | 分子名称: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | 登録日 | 2023-08-02 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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6ZX9
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![BU of 6zx9 by Molmil](/molmil-images/mine/6zx9) | Crystal structure of SIV Vpr,fused to T4 lysozyme, isolated from moustached monkey, bound to human DDB1 and human DCAF1 (amino acid residues 1046-1396) | 分子名称: | DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, GLYCEROL, ... | 著者 | Schwefel, D, Banchenko, S. | 登録日 | 2020-07-29 | 公開日 | 2021-07-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.519729 Å) | 主引用文献 | Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses. Plos Pathog., 17, 2021
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8B3D
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![BU of 8b3d by Molmil](/molmil-images/mine/8b3d) | |
3EI2
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![BU of 3ei2 by Molmil](/molmil-images/mine/3ei2) | |
6UE5
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![BU of 6ue5 by Molmil](/molmil-images/mine/6ue5) | Crystal structure of full-length human DCAF15-DDB1-deltaPBP-DDA1-RBM39 in complex with 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide | 分子名称: | 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide, DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, ... | 著者 | Knapp, M.S, Shu, W, Xie, L, Bussiere, D.E. | 登録日 | 2019-09-20 | 公開日 | 2019-12-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nat.Chem.Biol., 16, 2020
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8TL6
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![BU of 8tl6 by Molmil](/molmil-images/mine/8tl6) | Cryo-EM structure of DDB1deltaB-DDA1-DCAF5 | 分子名称: | DDB1- and CUL4-associated factor 5, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1 | 著者 | Yue, H, Hunkeler, M, Roy Burman, S.S, Fischer, E.S. | 登録日 | 2023-07-26 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature, 628, 2024
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7OOB
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![BU of 7oob by Molmil](/molmil-images/mine/7oob) | |
8OJH
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![BU of 8ojh by Molmil](/molmil-images/mine/8ojh) | Crystal structure of human CRBN-DDB1 in complex with compound 4 | 分子名称: | 1,2-ETHANEDIOL, 4-azanyl-2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-7-methoxy-isoindole-1,3-dione, DNA damage-binding protein 1, ... | 著者 | Cabry, M.P, Le Bihan, Y.-V, van Montfort, R.L.M. | 登録日 | 2023-03-24 | 公開日 | 2023-07-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | A Degron Blocking Strategy Towards Improved CRL4 CRBN Recruiting PROTAC Selectivity. Chembiochem, 24, 2023
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7OO3
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![BU of 7oo3 by Molmil](/molmil-images/mine/7oo3) | Pol II-CSB-CSA-DDB1-UVSSA (Structure1) | 分子名称: | CSB element, DNA damage-binding protein 1, DNA excision repair protein ERCC-6, ... | 著者 | Kokic, G, Cramer, P. | 登録日 | 2021-05-26 | 公開日 | 2021-10-06 | 最終更新日 | 2021-10-27 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis of human transcription-DNA repair coupling. Nature, 598, 2021
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2B5N
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![BU of 2b5n by Molmil](/molmil-images/mine/2b5n) | Crystal Structure of the DDB1 BPB Domain | 分子名称: | ISOPROPYL ALCOHOL, damage-specific DNA binding protein 1 | 著者 | Li, T, Chen, X, Garbutt, K.C, Zhou, P, Zheng, N. | 登録日 | 2005-09-28 | 公開日 | 2006-02-28 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase. Cell(Cambridge,Mass.), 124, 2006
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3I7O
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![BU of 3i7o by Molmil](/molmil-images/mine/3i7o) | Crystal Structure of DDB1 in Complex with the H-Box Motif of IQWD1 | 分子名称: | DNA damage-binding protein 1, IQ motif and WD repeat-containing protein 1 | 著者 | Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. | 登録日 | 2009-07-08 | 公開日 | 2009-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat.Struct.Mol.Biol., 17, 2010
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3I7N
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![BU of 3i7n by Molmil](/molmil-images/mine/3i7n) | Crystal Structure of DDB1 in Complex with the H-Box Motif of WDTC1 | 分子名称: | DNA damage-binding protein 1, WD and tetratricopeptide repeats protein 1 | 著者 | Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. | 登録日 | 2009-07-08 | 公開日 | 2009-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat.Struct.Mol.Biol., 17, 2010
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3I7L
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![BU of 3i7l by Molmil](/molmil-images/mine/3i7l) | Crystal Structure of DDB1 in Complex with the H-Box Motif of DDB2 | 分子名称: | DNA damage-binding protein 1, DNA damage-binding protein 2 | 著者 | Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. | 登録日 | 2009-07-08 | 公開日 | 2009-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat.Struct.Mol.Biol., 17, 2010
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3I7K
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![BU of 3i7k by Molmil](/molmil-images/mine/3i7k) | Crystal Structure of DDB1 in Complex with the H-Box Motif of WHX | 分子名称: | DNA damage-binding protein 1, X protein | 著者 | Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. | 登録日 | 2009-07-08 | 公開日 | 2009-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat.Struct.Mol.Biol., 17, 2010
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