6ZX9

Crystal structure of SIV Vpr,fused to T4 lysozyme, isolated from moustached monkey, bound to human DDB1 and human DCAF1 (amino acid residues 1046-1396)

Summary for 6ZX9

Entry DOI	10.2210/pdb6zx9/pdb
Descriptor	DNA damage-binding protein 1, DDB1- and CUL4-associated factor 1, Vpr protein fused to T4 lysozyme, ... (6 entities in total)
Functional Keywords	viral protein vpr, viral hijacking of human ubiquitin ligase crl4, ddb1, dcaf1, viral protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	198623.62
Authors	Schwefel, D.,Banchenko, S. (deposition date: 2020-07-29, release date: 2021-07-21, Last modification date: 2024-01-31)
Primary citation	Banchenko, S.,Krupp, F.,Gotthold, C.,Burger, J.,Graziadei, A.,O'Reilly, F.J.,Sinn, L.,Ruda, O.,Rappsilber, J.,Spahn, C.M.T.,Mielke, T.,Taylor, I.A.,Schwefel, D. Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses. Plos Pathog., 17:e1009775-e1009775, 2021 Cited by PubMed: 34339457 DOI: 10.1371/journal.ppat.1009775 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5197288426 Å)

Structure validation