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PDB: 45 件
8SVI
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BU of 8svi by Molmil
Ubiquitin variant i53:Mutant L67H with 53BP1 Tudor domain
分子名称: GLYCEROL, Tumor protein p53 binding protein 1, Ubiquitin Variant i53: Mutant L67H
著者Partridge, J.R, Holden, J.K, Wibowo, A.S, Mulichak, A.
登録日2023-05-16
公開日2024-03-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair.
Nat Commun, 15, 2024
8SVH
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BU of 8svh by Molmil
Ubiquitin variant i53 mutant L67R bound to 53BP1 Tudor Domain
分子名称: Tumor protein p53 binding protein 1, Ubiquitin variant i53: mutant L67R
著者Holden, J.K, Partridge, J.R, Wibowo, A.S, Mulichak, A.
登録日2023-05-16
公開日2024-03-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.16 Å)
主引用文献Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair.
Nat Commun, 15, 2024
8SVG
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BU of 8svg by Molmil
Ubiquitin variant i53 in complex with 53BP1 Tudor domain
分子名称: Tumor protein p53 binding protein 1, Ubiquitin variant i53
著者Holden, J.K, Partridge, J.R, Wibowo, A.S, Mulichak, A.
登録日2023-05-16
公開日2024-03-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.21 Å)
主引用文献Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair.
Nat Commun, 15, 2024
2G3R
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BU of 2g3r by Molmil
Crystal Structure of 53BP1 tandem tudor domains at 1.2 A resolution
分子名称: SULFATE ION, Tumor suppressor p53-binding protein 1
著者Lee, J, Botuyan, M.V, Thompson, J.R, Mer, G.
登録日2006-02-20
公開日2007-01-02
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair.
Cell(Cambridge,Mass.), 127, 2006
6VA5
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BU of 6va5 by Molmil
Tudor Domain of Tumor suppressor p53BP1 with MFP-4184
分子名称: 2-(4-methylpiperazin-1-yl)aniline, GLYCEROL, SULFATE ION, ...
著者Zeng, H, Dong, A, Headey, S, Gunzburg, M, Doak, B, James, L.I, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
登録日2019-12-16
公開日2020-04-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Tudor Domain of Tumor suppressor p53BP1 with MFP-4184
to be published
6VIP
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BU of 6vip by Molmil
TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008
分子名称: TP53-binding protein 1, UNKNOWN ATOM OR ION, {4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]phenyl}(4-ethylpiperazin-1-yl)methanone
著者The, J, Hong, Z, Dong, A, Headey, S, Gunzburg, M, Doak, B, James, L.I, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
登録日2020-01-13
公開日2020-02-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008
to be published
7LIN
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BU of 7lin by Molmil
X-ray structure of SPOP MATH domain (D140G) in complex with a 53BP1 peptide
分子名称: SULFATE ION, Speckle-type POZ protein, TP53-binding protein 1 peptide
著者Botuyan, M.V, Cui, G, Mer, G.
登録日2021-01-27
公開日2021-04-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.
Sci Adv, 7, 2021
4RG2
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BU of 4rg2 by Molmil
Tudor Domain of Tumor suppressor p53BP1 with small molecule ligand
分子名称: 1,2-ETHANEDIOL, 3-bromo-N-[3-(tert-butylamino)propyl]benzamide, Tumor suppressor p53-binding protein 1, ...
著者Dong, A, Mader, P, James, L, Perfetti, M, Tempel, W, Frye, S, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
登録日2014-09-29
公開日2014-10-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.
ACS Chem. Biol., 10, 2015
8SVJ
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BU of 8svj by Molmil
Ubiquitin variant i53: mutant VHH with 53BP1 Tudor domain
分子名称: GLYCEROL, Tumor protein p53 binding protein 1, Ubiquitin varient i53 mutant VHH
著者Holden, J, Partridge, J.R, Wibowo, A.S, Mulichak, A.
登録日2023-05-16
公開日2024-03-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair.
Nat Commun, 15, 2024
3LGF
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BU of 3lgf by Molmil
Crystal structure of the 53BP1 tandem tudor domain in complex with p53K370me2
分子名称: DIMETHYLATED p53 Lysine 370 PEPTIDE, SULFATE ION, TRIETHYLENE GLYCOL, ...
著者Roy, S, Kutateladze, T.G.
登録日2010-01-20
公開日2010-03-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.
J.Mol.Biol., 398, 2010
8F0W
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BU of 8f0w by Molmil
Tudor Domain of Tumor suppressor p53BP1 with MFP-5956
分子名称: 1-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]butan-1-one, TP53-binding protein 1, UNKNOWN ATOM OR ION
著者The, J, Hong, Z, Dong, A, Headey, S, Gunzburg, M, Doak, B, James, L.I, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
登録日2022-11-04
公開日2023-01-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Tudor Domain of Tumor suppressor p53BP1 with MFP-5956
to be published
3LGL
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BU of 3lgl by Molmil
Crystal structure of the 53BP1 tandem tudor domain in complex with p53K382me2
分子名称: DIMETHYLATED p53 LYSINE 382 PEPTIDE, SULFATE ION, TRIETHYLENE GLYCOL, ...
著者Roy, S, Kutateladze, T.G.
登録日2010-01-20
公開日2010-03-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.
J.Mol.Biol., 398, 2010
8SWJ
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BU of 8swj by Molmil
Co-crystal structure of 53BP1 tandem Tudor domains in complex with UNC8531
分子名称: (3S)-N-(4'-carbamoyl[1,1'-biphenyl]-3-yl)-1-[4-(4-methylpiperazin-1-yl)pyridine-2-carbonyl]piperidine-3-carboxamide, TP53-binding protein 1, UNKNOWN ATOM OR ION
著者Zeng, H, Dong, A, Shell, D.J, Foley, C, Pearce, K.H, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
登録日2023-05-18
公開日2023-08-02
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Co-crystal structure of 53BP1 tandem Tudor domains in complex with UNC8531
To be published
6MXY
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BU of 6mxy by Molmil
Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC3351
分子名称: N-[3-(tert-butylamino)propyl]-3-(trifluoromethyl)benzamide, PHOSPHATE ION, TP53-binding protein 1
著者Cui, G, Botuyan, M.V, Mer, G.
登録日2018-10-31
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.624 Å)
主引用文献An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
6IUA
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BU of 6iua by Molmil
Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (S1678D)
分子名称: Importin subunit alpha-1, Peptide from TP53-binding protein 1
著者Matsuura, Y.
登録日2018-11-27
公開日2019-01-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha.
Biochem. Biophys. Res. Commun., 510, 2019
2IG0
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BU of 2ig0 by Molmil
Structure of 53BP1/methylated histone peptide complex
分子名称: Dimethylated Histone H4-K20 peptide, SULFATE ION, Tumor suppressor p53-binding protein 1
著者Mer, G.
登録日2006-09-22
公開日2007-01-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair.
Cell(Cambridge,Mass.), 127, 2006
8EOM
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BU of 8eom by Molmil
TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-5973
分子名称: 4-(4-methylpiperazine-1-sulfonyl)benzamide, SULFATE ION, TP53-binding protein 1, ...
著者The, J, Hong, Z, Headey, S, Gunzburg, M, Doak, B, James, L.I, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
登録日2022-10-03
公開日2023-01-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-5973
to be published
8T2D
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BU of 8t2d by Molmil
Ubiquitin variant i53:Mutant T12Y.T14E.L67R with 53BP1 Tudor domain
分子名称: Tumor protein p53 binding protein 1, Ubiquitin variant i53
著者Partridge, J.R, Holden, J.K, Wibowo, A.S, Mulichak, A.
登録日2023-06-05
公開日2024-03-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.751 Å)
主引用文献Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair.
Nat Commun, 15, 2024
5Z78
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BU of 5z78 by Molmil
Structure of TIRR/53BP1 complex
分子名称: TP53-binding protein 1, Tudor-interacting repair regulator protein
著者Dai, Y.X, Shan, S.
登録日2018-01-27
公開日2018-06-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.762 Å)
主引用文献Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR
Nat Commun, 9, 2018
4X34
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BU of 4x34 by Molmil
Crystal structure of the 53BP1 tandem tudor domain in complex with p53K381acK382me2
分子名称: THR-SER-ARG-HIS-ALY-MLY-LEU-MET-PHE-LYS, Tumor suppressor p53-binding protein 1
著者Tong, Q, Kutateladze, T.G.
登録日2014-11-27
公開日2015-03-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献An Acetyl-Methyl Switch Drives a Conformational Change in p53.
Structure, 23, 2015
6IU7
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BU of 6iu7 by Molmil
Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (wild-type)
分子名称: Importin subunit alpha-1, Peptide from TP53-binding protein 1
著者Matsuura, Y.
登録日2018-11-27
公開日2019-01-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha.
Biochem. Biophys. Res. Commun., 510, 2019
3LH0
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BU of 3lh0 by Molmil
Crystal structure of the 53BP1 tandem tudor domain in complex with p53K372me2
分子名称: DIMETHYLATED p53 LYSINE 372 PEPTIDE, SULFATE ION, TRIETHYLENE GLYCOL, ...
著者Roy, S, Kutateladze, T.G.
登録日2010-01-21
公開日2010-03-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.
J.Mol.Biol., 398, 2010
8HKW
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BU of 8hkw by Molmil
Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal
分子名称: Importin subunit alpha-3, Peptide from TP53-binding protein 1
著者Matsuura, Y.
登録日2022-11-28
公開日2022-12-21
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystallographic data of an importin-alpha 3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal.
Data Brief, 47, 2023
6UPT
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BU of 6upt by Molmil
Tudor Domain of Tumor suppressor p53BP1 with MFP-2706
分子名称: 2-((2-chlorobenzyl)thio)-4,5-dihydro-1H-imidazole, TP53-binding protein 1, UNKNOWN ATOM OR ION
著者The, J, Dong, A, Headey, S, Gunzburg, M, Doak, B, James, L.I, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
登録日2019-10-18
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Tudor Domain of Tumor suppressor p53BP1 with MFP-2706
to be published
5ZCJ
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BU of 5zcj by Molmil
Crystal structure of complex
分子名称: TP53-binding protein 1, Tudor-interacting repair regulator protein
著者Wang, J, Yuan, Z, Cui, Y, Xie, R, Wang, M, Ma, Y, Yu, X, Liu, X.
登録日2018-02-17
公開日2018-06-27
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.004 Å)
主引用文献Crystal structure of complex
To Be Published

 

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