4RG2

Tudor Domain of Tumor suppressor p53BP1 with small molecule ligand

Summary for 4RG2

• Entry DOI: 10.2210/pdb4rg2/pdb
• Descriptor: Tumor suppressor p53-binding protein 1, 3-bromo-N-[3-(tert-butylamino)propyl]benzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: 53bp1 tudor, structural genomics, structural genomics consortium, sgc, transcription
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q12888
• Total number of polymer chains: 2
• Total formula weight: 28743.22

Authors

Dong, A.,Mader, P.,James, L.,Perfetti, M.,Tempel, W.,Frye, S.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2014-09-29, release date: 2014-10-15, Last modification date: 2023-09-20)

• Primary citation: Perfetti, M.T.,Baughman, B.M.,Dickson, B.M.,Mu, Y.,Cui, G.,Mader, P.,Dong, A.,Norris, J.L.,Rothbart, S.B.,Strahl, B.D.,Brown, P.J.,Janzen, W.P.,Arrowsmith, C.H.,Mer, G.,McBride, K.M.,James, L.I.,Frye, S.V.; Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.; ACS Chem. Biol., 10:1072-1081, 2015; PubMed: 25590533; DOI: 10.1021/cb500956g

Experimental method

X-RAY DIFFRACTION (1.5 Å)