1EBM
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![BU of 1ebm by Molmil](/molmil-images/mine/1ebm) | CRYSTAL STRUCTURE OF THE HUMAN 8-OXOGUANINE GLYCOSYLASE (HOGG1) BOUND TO A SUBSTRATE OLIGONUCLEOTIDE | 分子名称: | 8-OXOGUANINE DNA GLYCOSYLASE, CALCIUM ION, DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3'), ... | 著者 | Bruner, S.D, Norman, D.P, Verdine, G.L. | 登録日 | 2000-01-24 | 公開日 | 2000-03-20 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Nature, 403, 2000
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6RLW
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![BU of 6rlw by Molmil](/molmil-images/mine/6rlw) | |
2I5W
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![BU of 2i5w by Molmil](/molmil-images/mine/2i5w) | |
5AN4
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![BU of 5an4 by Molmil](/molmil-images/mine/5an4) | Crystal structure of the human 8-oxoguanine glycosylase (OGG1) processed with the CrystalDirect automated mounting and cryo-cooling technology | 分子名称: | N-GLYCOSYLASE/DNA LYASE, SULFATE ION | 著者 | Zander, U, Ytre-Arne, M, Dalhus, B, Hoffmann, G, Cornaciu, I, Cipriani, F, Marquez, J.A. | 登録日 | 2015-09-04 | 公開日 | 2016-04-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Automated Harvesting and Processing of Protein Crystals Through Laser Photoablation. Acta Crystallogr.,Sect.D, 72, 2016
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2XHI
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![BU of 2xhi by Molmil](/molmil-images/mine/2xhi) | Separation-of-function mutants unravel the dual reaction mode of human 8-oxoguanine DNA glycosylase | 分子名称: | 5'-D(*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | 著者 | Dalhus, B, Forsbring, M, Helle, I.H, Backe, P.H, Forstrom, R.J, Alseth, I, Bjoras, M. | 登録日 | 2010-06-16 | 公開日 | 2011-01-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Separation-of-Function Mutants Unravel the Dual- Reaction Mode of Human 8-Oxoguanine DNA Glycosylase. Structure, 19, 2011
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7PZ1
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![BU of 7pz1 by Molmil](/molmil-images/mine/7pz1) | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH8535 | 分子名称: | 1,2-ETHANEDIOL, 4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(3-methoxy-4-methyl-phenyl)piperidine-1-carboxamide, GLYCEROL, ... | 著者 | Scaletti, E.R, Helleday, T, Stenmark, P. | 登録日 | 2021-10-11 | 公開日 | 2022-11-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1. Chemmedchem, 18, 2023
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3F0Z
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![BU of 3f0z by Molmil](/molmil-images/mine/3f0z) | |
1FN7
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![BU of 1fn7 by Molmil](/molmil-images/mine/1fn7) | COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN | 分子名称: | 8-OXOGUANINE DNA GLYCOSYLASE 1, CALCIUM ION, DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*CP*C)-3'), ... | 著者 | Norman, D.P.G, Bruner, S.D, Verdine, G.L. | 登録日 | 2000-08-21 | 公開日 | 2001-04-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein. J.Am.Chem.Soc., 123, 2001
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4EJY
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![BU of 4ejy by Molmil](/molmil-images/mine/4ejy) | Structure of MBOgg1 in complex with high affinity DNA ligand | 分子名称: | 3-Methyladenine DNA glycosylase, DNA (5'-D(*AP*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*CP*C)-3'), DNA (5'-D(*T*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'), ... | 著者 | Jiang, T, Yu, H.J, Bi, L.J, Zhang, X.E, Yang, M.Z. | 登録日 | 2012-04-08 | 公開日 | 2013-03-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of MBOgg1 in complex with two abasic DNA ligands J.Struct.Biol., 181, 2013
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7QEL
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![BU of 7qel by Molmil](/molmil-images/mine/7qel) | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH011247 | 分子名称: | (2~{R})-~{N}-(4,5,6,7-tetrahydro-1,2-benzoxazol-3-yl)spiro[2.3]hexane-2-carboxamide, N-glycosylase/DNA lyase, NICKEL (II) ION | 著者 | Davies, J.R, Scaletti, E.R, Stenmark, P. | 登録日 | 2021-12-03 | 公開日 | 2022-12-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH011247 To Be Published
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3F10
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1HU0
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![BU of 1hu0 by Molmil](/molmil-images/mine/1hu0) | CRYSTAL STRUCTURE OF AN HOGG1-DNA BOROHYDRIDE TRAPPED INTERMEDIATE COMPLEX | 分子名称: | 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 8-OXOGUANINE, ... | 著者 | Fromme, J.C, Bruner, S.D, Yang, W, Karplus, M, Verdine, G.L. | 登録日 | 2001-01-03 | 公開日 | 2003-02-25 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Product-Assisted Catalysis in base-excision DNA Repair Nat.Struct.Biol., 10, 2003
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4EJZ
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![BU of 4ejz by Molmil](/molmil-images/mine/4ejz) | Structure of MBOgg1 in complex with low affinity DNA ligand | 分子名称: | 3-Methyladenine DNA glycosylase, DNA (5'-D(*AP*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*CP*C)-3'), DNA (5'-D(*T*GP*GP*TP*AP*GP*AP*CP*TP*TP*GP*GP*AP*CP*GP*C)-3') | 著者 | Jiang, T, Yu, H.J, Bi, L.J, Zhang, X.E, Yang, M.Z. | 登録日 | 2012-04-08 | 公開日 | 2013-03-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Crystal structures of MBOgg1 in complex with two abasic DNA ligands J.Struct.Biol., 181, 2013
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1N39
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![BU of 1n39 by Molmil](/molmil-images/mine/1n39) | Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase | 分子名称: | CALCIUM ION, DNA complement strand, DNA inhibitor strand, ... | 著者 | Norman, D.P, Chung, S.J, Verdine, G.L. | 登録日 | 2002-10-25 | 公開日 | 2003-03-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase Biochemistry, 42, 2003
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6G3X
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![BU of 6g3x by Molmil](/molmil-images/mine/6g3x) | |
6W13
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![BU of 6w13 by Molmil](/molmil-images/mine/6w13) | |
6G3Y
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![BU of 6g3y by Molmil](/molmil-images/mine/6g3y) | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH5675 | 分子名称: | 4-(4-azanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide, ACETATE ION, N-glycosylase/DNA lyase, ... | 著者 | Masuyer, G, Helleday, T, Stenmark, P. | 登録日 | 2018-03-26 | 公開日 | 2018-11-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science, 362, 2018
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7AYY
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![BU of 7ayy by Molmil](/molmil-images/mine/7ayy) | Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, N-glycosylase/DNA lyase, ... | 著者 | Masuyer, G, Davies, J.R, Stenmark, P. | 登録日 | 2020-11-13 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science, 376, 2022
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7AYZ
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![BU of 7ayz by Molmil](/molmil-images/mine/7ayz) | |
7AZ0
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![BU of 7az0 by Molmil](/molmil-images/mine/7az0) | |
6G40
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![BU of 6g40 by Molmil](/molmil-images/mine/6g40) | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH9525 | 分子名称: | ACETATE ION, DI(HYDROXYETHYL)ETHER, N-glycosylase/DNA lyase, ... | 著者 | Masuyer, G, Helleday, T, Stenmark, P. | 登録日 | 2018-03-26 | 公開日 | 2019-04-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1. Chemmedchem, 18, 2023
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6W0M
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![BU of 6w0m by Molmil](/molmil-images/mine/6w0m) | |
6W0R
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![BU of 6w0r by Molmil](/molmil-images/mine/6w0r) | |
1N3A
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![BU of 1n3a by Molmil](/molmil-images/mine/1n3a) | Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase | 分子名称: | CALCIUM ION, DNA complement strand, DNA inhibitor strand, ... | 著者 | Norman, D.P, Chung, S.J, Verdine, G.L. | 登録日 | 2002-10-25 | 公開日 | 2003-03-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase Biochemistry, 42, 2003
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1N3C
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![BU of 1n3c by Molmil](/molmil-images/mine/1n3c) | Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase | 分子名称: | 8-oxoG-containing DNA, CALCIUM ION, DNA complement strand, ... | 著者 | Norman, D.P, Chung, S.J, Verdine, G.L. | 登録日 | 2002-10-25 | 公開日 | 2003-03-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase Biochemistry, 42, 2003
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