7PZ1

Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH8535

This is a non-PDB format compatible entry.

Summary for 7PZ1

• Entry DOI: 10.2210/pdb7pz1/pdb
• Descriptor: N-glycosylase/DNA lyase, 4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(3-methoxy-4-methyl-phenyl)piperidine-1-carboxamide, NICKEL (II) ION, ... (6 entities in total)
• Functional Keywords: glycosylase, dna binding protein
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 3
• Total formula weight: 108122.15

Authors

Scaletti, E.R.,Helleday, T.,Stenmark, P. (deposition date: 2021-10-11, release date: 2022-11-02, Last modification date: 2024-02-07)

• Primary citation: Wallner, O.,Cazares-Korner, A.,Scaletti, E.R.,Masuyer, G.,Bekkhus, T.,Visnes, T.,Mamonov, K.,Ortis, F.,Lundback, T.,Volkova, M.,Koolmeister, T.,Wiita, E.,Loseva, O.,Pandey, M.,Homan, E.,Benitez-Buelga, C.,Davies, J.,Scobie, M.,Warpman Berglund, U.,Kalderen, C.,Stenmark, P.,Helleday, T.,Michel, M.; Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1.; Chemmedchem, 18:e202200310-e202200310, 2023; PubMed: 36128847; DOI: 10.1002/cmdc.202200310

Experimental method

X-RAY DIFFRACTION (2.45 Å)