6G3X

Native Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1

Summary for 6G3X

• Entry DOI: 10.2210/pdb6g3x/pdb
• Descriptor: N-glycosylase/DNA lyase, NICKEL (II) ION (3 entities in total)
• Functional Keywords: n-glycosylase, dna lyase, dna binding protein
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 3
• Total formula weight: 107508.65

Authors

Masuyer, G.,Helleday, T.,Stenmark, P. (deposition date: 2018-03-26, release date: 2018-11-28, Last modification date: 2024-01-17)

• Primary citation: Visnes, T.,Cazares-Korner, A.,Hao, W.,Wallner, O.,Masuyer, G.,Loseva, O.,Mortusewicz, O.,Wiita, E.,Sarno, A.,Manoilov, A.,Astorga-Wells, J.,Jemth, A.S.,Pan, L.,Sanjiv, K.,Karsten, S.,Gokturk, C.,Grube, M.,Homan, E.J.,Hanna, B.M.F.,Paulin, C.B.J.,Pham, T.,Rasti, A.,Berglund, U.W.,von Nicolai, C.,Benitez-Buelga, C.,Koolmeister, T.,Ivanic, D.,Iliev, P.,Scobie, M.,Krokan, H.E.,Baranczewski, P.,Artursson, P.,Altun, M.,Jensen, A.J.,Kalderen, C.,Ba, X.,Zubarev, R.A.,Stenmark, P.,Boldogh, I.,Helleday, T.; Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.; Science, 362:834-839, 2018; PubMed: 30442810; DOI: 10.1126/science.aar8048

Experimental method

X-RAY DIFFRACTION (2.1 Å)