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PDB: 285 件
1VRD
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Crystal structure of Inosine-5'-monophosphate dehydrogenase (TM1347) from THERMOTOGA MARITIMA at 2.18 A resolution
分子名称: inosine-5'-monophosphate dehydrogenase
著者Joint Center for Structural Genomics (JCSG)
登録日2005-02-22
公開日2005-03-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Crystal structure of Inosine-5'-monophosphate dehydrogenase (TM1347) from THERMOTOGA MARITIMA at 2.18 A resolution
To be published
8C53
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Trypanosoma brucei IMP dehydrogenase (ori) crystallized in High Five cells reveals native ligands ATP, GDP and phosphate. Diffraction data collection at 100 K in cellulo; CrystFEL processing
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, ...
著者Lahey-Rudolph, J.M, Schoenherr, R, Boger, J, Harms, M, Kaiser, J, Nachtschatt, S, Wobbe, M, Duden, R, Bourenkov, G, Schneider, T, Redecke, L.
登録日2023-01-06
公開日2024-01-17
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A streamlined approach to structure elucidation using in cellulo crystallized recombinant proteins, InCellCryst.
Nat Commun, 15, 2024
8C51
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Trypanosoma brucei IMP dehydrogenase (cyto) crystallized in High Five cells revealing native ligands ATP, GDP and phosphate. Diffraction data collection at 100 K in cellulo
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, ...
著者Lahey-Rudolph, J.M, Schoenherr, R, Boger, J, Harms, M, Kaiser, J, Nachtschatt, S, Wobbe, M, Duden, R, Koenig, P, Bourenkov, G, Schneider, T, Redecke, L.
登録日2023-01-06
公開日2024-01-17
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A streamlined approach to structure elucidation using in cellulo crystallized recombinant proteins, InCellCryst.
Nat Commun, 15, 2024
6XWL
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Cystathionine beta-synthase from Toxoplasma gondii
分子名称: Cystathionine beta-synthase, PYRIDOXAL-5'-PHOSPHATE
著者Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A.
登録日2020-01-23
公開日2021-02-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.201 Å)
主引用文献Structural insight into the unique conformation of cystathionine beta-synthase from Toxoplasma gondii .
Comput Struct Biotechnol J, 19, 2021
6LK4
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Crystal structure of GMP reductase from Trypanosoma brucei in complex with guanosine 5'-triphosphate
分子名称: GUANOSINE-5'-TRIPHOSPHATE, Guanosine 5'-monophosphate Reductase, PHOSPHATE ION
著者Mase, H, Otani, T, Imamura, A, Nishimura, S, Inui, T.
登録日2019-12-18
公開日2020-03-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.503 Å)
主引用文献Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-beta-synthase domain.
Nat Commun, 11, 2020
6XYL
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Crystal structure of delta466-491 cystathionine beta-synthase from Toxoplasma gondii with L-serine
分子名称: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine beta-synthase
著者Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A.
登録日2020-01-30
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.151 Å)
主引用文献Structural insight into the unique conformation of cystathionine beta-synthase from Toxoplasma gondii .
Comput Struct Biotechnol J, 19, 2021
6E4T
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Structure of AMPK bound to activator
分子名称: 1-O-{6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carbonyl}-beta-D-glucopyranuronic acid, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, ...
著者Calabrese, M.F, Kurumbail, R.G.
登録日2018-07-18
公開日2018-08-08
最終更新日2018-09-05
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J. Med. Chem., 61, 2018
6E4U
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Structure of AMPK bound to activator
分子名称: 1-O-{6-chloro-5-[6-(dimethylamino)-2-methoxypyridin-3-yl]-1H-indole-3-carbonyl}-beta-D-glucopyranuronic acid, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, ...
著者Calabrese, M.F, Kurumbail, R.G.
登録日2018-07-18
公開日2018-08-08
最終更新日2018-09-05
実験手法X-RAY DIFFRACTION (3.27 Å)
主引用文献Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J. Med. Chem., 61, 2018
6E4W
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Structure of AMPK bound to activator
分子名称: 1-O-(4,6-difluoro-5-{4-[(2S)-oxan-2-yl]phenyl}-1H-indole-3-carbonyl)-beta-D-glucopyranuronic acid, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, ...
著者Calabrese, M.F, Kurumbail, R.G.
登録日2018-07-18
公開日2018-08-08
最終更新日2018-09-05
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J. Med. Chem., 61, 2018
7MYJ
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Structure of full length human AMPK (a2b1g1) in complex with a small molecule activator MSG011
分子名称: (5S,6R,7R,9R,13cR,14R,16aS)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5H,13cH-5,9-epoxy-4b,9a,1 5-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-ol, 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, ...
著者Ovens, A.J, Gee, Y.S, Ling, N.X.Y, Waters, N.J, Yu, D, Scott, J.W, Parker, M.W, Hoffman, N.J, Kemp, B.E, Baell, J.B, Oakhill, J.S, Langendorf, C.G.
登録日2021-05-21
公開日2022-06-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator.
Biochem.J., 479, 2022
6Y21
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Crystal structure of delta466-491 cystathionine beta-synthase from Toxoplasma gondii with L-Cystathionine
分子名称: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine beta-synthase
著者Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A.
登録日2020-02-14
公開日2021-02-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Cystathionine Beta-synthase from Toxoplasma gondii with PLP-Cystathionine
To Be Published
5EZV
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BU of 5ezv by Molmil
X-ray crystal structure of AMP-activated protein kinase alpha-2/alpha-1 RIM chimaera (alpha-2(1-347)/alpha-1(349-401)/alpha-2(397-end) beta-1 gamma-1) co-crystallized with C2 (5-(5-hydroxyl-isoxazol-3-yl)-furan-2-phosphonic acid)
分子名称: 3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7H-thieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-activated protein kinase catalytic subunit alpha-2/alpha-1 RIM SWAP chimera, 5'-AMP-activated protein kinase subunit beta-1, ...
著者Langendorf, C.G, Kemp, B.E.
登録日2015-11-26
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.
Nat Commun, 7, 2016
7OJ1
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Bacillus subtilis IMPDH in complex with Ap4A
分子名称: BIS(ADENOSINE)-5'-TETRAPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, MAGNESIUM ION
著者Giammarinaro, P.I, Bange, G.
登録日2021-05-13
公開日2022-09-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Diadenosine tetraphosphate regulates biosynthesis of GTP in Bacillus subtilis.
Nat Microbiol, 7, 2022
7OY9
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Crystal structure of GMP reductase from mycobacterium smegmatis.
分子名称: Guanosine 5'-monophosphate reductase
著者Dolezal, M, Klima, M, Pichova, I.
登録日2021-06-24
公開日2022-04-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-beta-synthase domain.
Febs J., 289, 2022
6Z3S
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BU of 6z3s by Molmil
Crystal structure of delta466-491 cystathionine beta-synthase from Toxoplasma gondii with O-Acetylserine
分子名称: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine beta-synthase
著者Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A.
登録日2020-05-21
公開日2021-06-02
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.048 Å)
主引用文献Structural insight into the unique conformation of cystathionine beta-synthase from Toxoplasma gondii .
Comput Struct Biotechnol J, 19, 2021
6GK9
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Inhibited structure of IMPDH from Pseudomonas aeruginosa
分子名称: (5~{S})-7-azanyl-5-(4-chlorophenyl)-2,4-bis(oxidanylidene)-1,5-dihydropyrano[2,3-d]pyrimidine-6-carbonitrile, Inosine-5'-monophosphate dehydrogenase, SULFATE ION
著者Labesse, G, Alexandre, T, Haouz, A, Munier-Lehmann, H.
登録日2018-05-18
公開日2019-02-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献First-in-class allosteric inhibitors of bacterial IMPDHs.
Eur J Med Chem, 167, 2019
6WUR
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Crystal structure of PRL-2 phosphatase C101D mutant in complex with the Bateman domain of CNNM3 magnesium transporter
分子名称: Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2, SODIUM ION
著者Kozlov, G, Gehring, K.
登録日2020-05-05
公開日2020-07-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.882 Å)
主引用文献Crystal structure of PRL phosphatase C104D mutant in complex with the Bateman domain of CNNM magnesium transporter
J.Biol.Chem., 2020
1ZFJ
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INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH; EC 1.1.1.205) FROM STREPTOCOCCUS PYOGENES
分子名称: INOSINE MONOPHOSPHATE DEHYDROGENASE, INOSINIC ACID
著者Zhang, R, Evans, G, Rotella, F.J, Westbrook, E.M, Beno, D, Huberman, E, Joachimiak, A, Collart, F.R.
登録日1999-03-29
公開日2000-03-29
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase.
Biochemistry, 38, 1999
7JHG
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Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C) and Fab-nanobody
分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Yan, Y, Murkherjee, S, Zhou, X.E, Xu, T.H, Xu, H.E, Kossiakoff, A.A, Melcher, K.
登録日2020-07-20
公開日2021-07-21
最終更新日2021-12-15
実験手法ELECTRON MICROSCOPY (3.47 Å)
主引用文献Structure of an AMPK complex in an inactive, ATP-bound state.
Science, 373, 2021
7JHH
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Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Fab and nanobody
分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Yan, Y, Murkherjee, S, Zhou, X.E, Xu, T.H, Xu, H.E, Kossiakoff, A.A, Melcher, K.
登録日2020-07-20
公開日2021-07-21
最終更新日2021-12-15
実験手法ELECTRON MICROSCOPY (3.92 Å)
主引用文献Structure of an AMPK complex in an inactive, ATP-bound state.
Science, 373, 2021
7JIJ
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ATP-bound AMP-activated protein kinase
分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Yan, Y, Zhou, X.E, Powell, K, Xu, T, Brunzelle, J.S, Xu, H.X, Melcher, K.
登録日2020-07-23
公開日2021-07-28
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (5.5 Å)
主引用文献Structure of an AMPK complex in an inactive, ATP-bound state.
Science, 373, 2021
8F6D
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Crystal structure of the CNNM2 CBS-pair domain in complex with ARL15
分子名称: ADP-ribosylation factor-like protein 15, Metal transporter CNNM2
著者Kozlov, G, Mahbub, L, Gehring, K.
登録日2022-11-16
公開日2023-07-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15.
Elife, 12, 2023
6GJV
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BU of 6gjv by Molmil
apo-structure of IMPDH from Pseudomonas aeruginosa
分子名称: Inosine-5'-monophosphate dehydrogenase
著者Labesse, G, Haouz, A, Alexandre, T, Munier-Lehmann, H.
登録日2018-05-17
公開日2019-02-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献First-in-class allosteric inhibitors of bacterial IMPDHs.
Eur J Med Chem, 167, 2019
6JIG
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BU of 6jig by Molmil
Crystal structure of GMP reductase C318A from Trypanosoma brucei in complex with guanosine 5'-monophosphate
分子名称: GMP reductase, GUANOSINE-5'-MONOPHOSPHATE, POTASSIUM ION
著者Mase, H, Imamura, A, Nishimura, S, Inui, T.
登録日2019-02-21
公開日2020-02-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.903 Å)
主引用文献Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-beta-synthase domain.
Nat Commun, 11, 2020
6JL8
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Crystal structure of GMP reductase C318A from Trypanosoma brucei
分子名称: GMP reductase
著者Mase, H, Imamura, A, Nishimura, S, Inui, T.
登録日2019-03-04
公開日2020-03-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.804 Å)
主引用文献Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-beta-synthase domain.
Nat Commun, 11, 2020

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