7MYJ

Structure of full length human AMPK (a2b1g1) in complex with a small molecule activator MSG011

Summary for 7MYJ

• Entry DOI: 10.2210/pdb7myj/pdb
• Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (6 entities in total)
• Functional Keywords: activator, kinase, ampk, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 268660.49

Authors

Ovens, A.J.,Gee, Y.S.,Ling, N.X.Y.,Waters, N.J.,Yu, D.,Scott, J.W.,Parker, M.W.,Hoffman, N.J.,Kemp, B.E.,Baell, J.B.,Oakhill, J.S.,Langendorf, C.G. (deposition date: 2021-05-21, release date: 2022-06-29, Last modification date: 2023-10-18)

• Primary citation: Ovens, A.J.,Gee, Y.S.,Ling, N.X.Y.,Yu, D.,Hardee, J.P.,Chung, J.D.,Ngoei, K.R.W.,Waters, N.J.,Hoffman, N.J.,Scott, J.W.,Loh, K.,Spengler, K.,Heller, R.,Parker, M.W.,Lynch, G.S.,Huang, F.,Galic, S.,Kemp, B.E.,Baell, J.B.,Oakhill, J.S.,Langendorf, C.G.; Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator.; Biochem.J., 479:1181-1204, 2022; PubMed: 35552369; DOI: 10.1042/BCJ20220067

Experimental method

X-RAY DIFFRACTION (2.95 Å)