6GK9

Inhibited structure of IMPDH from Pseudomonas aeruginosa

Summary for 6GK9

• Entry DOI: 10.2210/pdb6gk9/pdb
• Related: 6GJV
• Descriptor: Inosine-5'-monophosphate dehydrogenase, (5~{S})-7-azanyl-5-(4-chlorophenyl)-2,4-bis(oxidanylidene)-1,5-dihydropyrano[2,3-d]pyrimidine-6-carbonitrile, SULFATE ION, ... (4 entities in total)
• Functional Keywords: imp dehydrogenase, nucleotide biosynthesis, allosteric regulation, oxidoreductase
• Biological source: Pseudomonas aeruginosa PAO1
• Total number of polymer chains: 8
• Total formula weight: 432239.05

Authors

Labesse, G.,Alexandre, T.,Haouz, A.,Munier-Lehmann, H. (deposition date: 2018-05-18, release date: 2019-02-27, Last modification date: 2024-01-17)

• Primary citation: Alexandre, T.,Lupan, A.,Helynck, O.,Vichier-Guerre, S.,Dugue, L.,Gelin, M.,Haouz, A.,Labesse, G.,Munier-Lehmann, H.; First-in-class allosteric inhibitors of bacterial IMPDHs.; Eur J Med Chem, 167:124-132, 2019; PubMed: 30769241; DOI: 10.1016/j.ejmech.2019.01.064

Experimental method

X-RAY DIFFRACTION (2.54 Å)