6GK9

Inhibited structure of IMPDH from Pseudomonas aeruginosa

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Inosine-5'-monophosphate dehydrogenase	polymer	509	53938.7	8	UniProt (Q9HXM5) Pfam (PF00478) Pfam (PF00571)	Pseudomonas aeruginosa PAO1	IMPDH
2	I, J (A, D)	(5~{S})-7-azanyl-5-(4-chlorophenyl)-2,4-bis(oxidanylidene)-1,5-dihydropyrano[2,3-d]pyrimidine-6-carbonitrile	non-polymer		316.7	2	Chemie (F2K)
3	K (E)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	L, M, N, O, P... (A, B, C, D, E...)	water	water		18.0	982	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 489 (UniProt: Q9HXM5)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	431509.6
Non-Polymers*	Number of molecules	3
	Total formula weight	729.5
All*	Total formula weight	432239.1

*Water molecules are not included.