7RFX
| Importin alpha2 in complex with MERS ORF4B | 分子名称: | Importin subunit alpha-1, ORF4b | 著者 | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | 登録日 | 2021-07-14 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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7RFZ
| Importin alpha 2 in complex with MERS ORF4B NLS peptide | 分子名称: | Importin subunit alpha-1, ORF4b | 著者 | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | 登録日 | 2021-07-14 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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7RG4
| Importin alpha2 in complex with p50 NLS | 分子名称: | Importin subunit alpha-1, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit | 著者 | Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K. | 登録日 | 2021-07-14 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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7RG3
| Importin alpha2 in complex with MERS ORF4B R37A mutant | 分子名称: | Importin subunit alpha-1, ORF4b | 著者 | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | 登録日 | 2021-07-14 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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7RG6
| Importin alpha2 in complex with ORF4B Bat coronavirus HKU5 | 分子名称: | Importin subunit alpha-1, Non-structural protein ORF4b | 著者 | Foster, J.K, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | 登録日 | 2021-07-14 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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7RG2
| Importin alpha2 in complex with MERS ORF4B R33A mutant | 分子名称: | Importin subunit alpha-1, ORF4b | 著者 | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | 登録日 | 2021-07-14 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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7RG5
| Importin alpha3 in complex with p50 NLS | 分子名称: | Importin subunit alpha-3, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit | 著者 | Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K. | 登録日 | 2021-07-14 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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7RHT
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8QXW
| HCMV DNA polymerase processivity factor UL44 unphosphorylated NLS 410-433 bound to mouse importin alpha 2 | 分子名称: | DNA polymerase processivity factor, Importin subunit alpha-1 | 著者 | Cross, E.M, Marin, O, Ariawan, D, Aragao, D, Cozza, G, Di Iorio, E, Forwood, J.K, Alvisi, G. | 登録日 | 2023-10-25 | 公開日 | 2023-11-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44. Febs Lett., 598, 2024
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8QXX
| HCMV DNA polymerase processivity factor UL44 phosphorylated NLS 410-433 bound to mouse importin alpha 2 | 分子名称: | DNA polymerase processivity factor, Importin subunit alpha-1 | 著者 | Cross, E.M, Marin, O, Ariawan, D, Aragao, D, Cozza, G, Di Iorio, E, Forwood, J.K, Alvisi, G. | 登録日 | 2023-10-25 | 公開日 | 2023-11-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44. Febs Lett., 598, 2024
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4TNM
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4UAF
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8SUD
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4U2X
| Ebola virus VP24 in complex with Karyopherin alpha 5 C-terminus | 分子名称: | CHLORIDE ION, Importin subunit alpha-6, Membrane-associated protein VP24 | 著者 | Xu, W, Leung, D, Borek, D, Amarasinghe, G. | 登録日 | 2014-07-18 | 公開日 | 2014-08-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.153 Å) | 主引用文献 | Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1. Cell Host Microbe, 16, 2014
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4U5L
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4U5V
| IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | 分子名称: | Importin subunit alpha-1, N~2~-{[5-(pyridin-3-yl)thiophen-2-yl]methyl}-L-lysinamide | 著者 | Stewart, M, Valkov, E, Holvey, R.S. | 登録日 | 2014-07-25 | 公開日 | 2015-05-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.968 Å) | 主引用文献 | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
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4U5N
| IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | 分子名称: | Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzyl]-L-lysyl-N-[(1R,2S,3R)-1-{[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]amino}-1,3-dihydroxybutan-2-yl]glycinamide | 著者 | Stewart, M, Valkov, E, Holvey, R.S. | 登録日 | 2014-07-25 | 公開日 | 2015-05-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
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4U5S
| IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | 分子名称: | Importin subunit alpha-1, N-[(2S)-2-[(N~2~-acetyl-D-lysyl)amino]-3-(pyridin-3-ylmethoxy)propyl]-L-allothreonyl-D-phenylalaninamide | 著者 | Stewart, M, Valkov, E, Holvey, R.S. | 登録日 | 2014-07-25 | 公開日 | 2015-05-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
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4U54
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4UAD
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4U58
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4U5O
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4U5U
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4UAE
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8U36
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