7RG5

Importin alpha3 in complex with p50 NLS

Summary for 7RG5

Entry DOI	10.2210/pdb7rg5/pdb
Descriptor	Importin subunit alpha-3, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit (3 entities in total)
Functional Keywords	complex, transportin, importin, transport protein-viral protein complex, transport protein/viral protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	55301.57
Authors	Smith, K.M.,Tsimbalyuk, S.,Aragao, D.,Forwood, J.K. (deposition date: 2021-07-14, release date: 2021-08-25, Last modification date: 2023-10-25)
Primary citation	Munasinghe, T.S.,Edwards, M.R.,Tsimbalyuk, S.,Vogel, O.A.,Smith, K.M.,Stewart, M.,Foster, J.K.,Bosence, L.A.,Aragao, D.,Roby, J.A.,Basler, C.F.,Forwood, J.K. MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13:1604-1604, 2022 Cited by PubMed: 35338144 DOI: 10.1038/s41467-022-28851-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation