4U2X

Ebola virus VP24 in complex with Karyopherin alpha 5 C-terminus

Summary for 4U2X

Entry DOI	10.2210/pdb4u2x/pdb
Descriptor	Membrane-associated protein VP24, Importin subunit alpha-6, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	evp24, importin alpha6, immune antagonist, viral protein
Biological source	Zaire ebolavirus (ZEBOV) More
Total number of polymer chains	6
Total formula weight	131767.07
Authors	Xu, W.,Leung, D.,Borek, D.,Amarasinghe, G. (deposition date: 2014-07-18, release date: 2014-08-13, Last modification date: 2023-12-27)
Primary citation	Xu, W.,Edwards, M.R.,Borek, D.M.,Feagins, A.R.,Mittal, A.,Alinger, J.B.,Berry, K.N.,Yen, B.,Hamilton, J.,Brett, T.J.,Pappu, R.V.,Leung, D.W.,Basler, C.F.,Amarasinghe, G.K. Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1. Cell Host Microbe, 16:187-200, 2014 Cited by PubMed: 25121748 DOI: 10.1016/j.chom.2014.07.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.153 Å)

Structure validation