3WCJ
 
 | | The complex structure of HsSQS wtih ligand,E5700 | | 分子名称: | (3R)-3-({2-benzyl-6-[(3R,4S)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridin-3-yl}ethynyl)-1-azabicyclo[2.2.2]octan-3-ol, Squalene synthase | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | | 登録日 | 2013-05-27 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WEF
 | | Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate | | 分子名称: | S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, Squalene synthase | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J. | | 登録日 | 2013-07-07 | | 公開日 | 2014-02-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
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3WCI
 | | The complex structure of HsSQS wtih ligand,BPH1325 | | 分子名称: | Squalene synthase, hydrogen [(1R)-1-hydroxy-2-(3-pentadecyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | | 登録日 | 2013-05-27 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WEH
 | | Crystal structure of the human squalene synthase in complex with presqualene pyrophosphate | | 分子名称: | MAGNESIUM ION, Squalene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J. | | 登録日 | 2013-07-07 | | 公開日 | 2014-02-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
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3WCG
 | | The complex structure of TcSQS with ligand, BPH1344 | | 分子名称: | Farnesyltransferase, putative, hydrogen [(1R)-2-(3-pentadecyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | | 登録日 | 2013-05-27 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WCA
 | | The complex structure of TcSQS with ligand, FSPP | | 分子名称: | Farnesyltransferase, putative, MAGNESIUM ION, ... | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Oldfield, E, Guo, R.T. | | 登録日 | 2013-05-26 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WEI
 | | Crystal structure of the human squalene synthase Y73A mutant in complex with presqualene pyrophosphate | | 分子名称: | MANGANESE (II) ION, Squalene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J. | | 登録日 | 2013-07-07 | | 公開日 | 2014-02-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
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3WSB
 | | The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole | | 分子名称: | Farnesyltransferase, putative, N-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, ... | | 著者 | Shang, N, Li, Q, Huang, C.H, Oldfield, E, Guo, R.T. | | 登録日 | 2014-03-05 | | 公開日 | 2015-04-01 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole
To be Published
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3WE9
 | | The crystal structure of YisP from Bacillus subtilis subsp. subtilis strain 168 | | 分子名称: | Putative phytoene/squalene synthase YisP, TRIETHYLENE GLYCOL | | 著者 | Hu, Y, Huang, C.H, Chan, H.C, Ko, T.P, Feng, X, Oldfield, E, Guo, R.T. | | 登録日 | 2013-07-02 | | 公開日 | 2014-07-02 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Crystal structure of Bacillus subtilis YisP in complex with a PEG fragment
To be Published
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3WEJ
 | | Crystal structure of the human squalene synthase F288A mutant in complex with presqualene pyrophosphate | | 分子名称: | MAGNESIUM ION, Squalene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J. | | 登録日 | 2013-07-07 | | 公開日 | 2014-02-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
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3WCC
 | | The complex structure of TcSQS with ligand, E5700 | | 分子名称: | (3R)-3-({2-benzyl-6-[(3R,4S)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridin-3-yl}ethynyl)-1-azabicyclo[2.2.2]octan-3-ol, Farnesyltransferase, putative | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | | 登録日 | 2013-05-27 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WEG
 | | Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate and magnesium ion | | 分子名称: | MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, Squalene synthase | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J. | | 登録日 | 2013-07-07 | | 公開日 | 2014-02-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
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3W7F
 | | Crystal structure of the C(30) carotenoid dehydrosqualene synthase from staphylococcus aureus complexed with farnesyl thiopyrophosphate | | 分子名称: | Dehydrosqualene synthase, MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E. | | 登録日 | 2013-02-28 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
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3WSA
 | | The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole | | 分子名称: | N-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, Squalene synthase | | 著者 | Shang, N, Li, Q, Huang, C.H, Oldfield, E, Guo, R.T. | | 登録日 | 2014-03-05 | | 公開日 | 2015-04-01 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | SQ109, a new drug lead for Chagas disease.
Antimicrob.Agents Chemother., 59, 2015
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3VJA
 | | Crystal structure of the human squalene synthase | | 分子名称: | NICKEL (II) ION, Squalene synthase | | 著者 | Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J. | | 登録日 | 2011-10-14 | | 公開日 | 2012-04-11 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
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3VJB
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3VJE
 | | Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus in complex with zaragozic acid A | | 分子名称: | Dehydrosqualene synthase, Zaragozic acid A | | 著者 | Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J. | | 登録日 | 2011-10-14 | | 公開日 | 2012-04-11 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
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3WCD
 | | The complex structure of HsSQS wtih ligand, WC-9 | | 分子名称: | 2-(4-phenoxyphenoxy)ethyl thiocyanate, Squalene synthase | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | | 登録日 | 2013-05-27 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WCB
 | | The complex structure of TcSQS with ligand, BPH1237 | | 分子名称: | Farnesyltransferase, putative, hydrogen [(1R)-2-(3-decyl-1H-imidazol-3-ium-1-yl)-1-hydroxy-1-phosphonoethyl]phosphonate | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | | 登録日 | 2013-05-27 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WCL
 | | The complex structure of HsSQS wtih ligand,BPH1344 | | 分子名称: | Squalene synthase, hydrogen [(1R)-2-(3-pentadecyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | | 登録日 | 2013-05-28 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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