3WSB

The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole

Summary for 3WSB

• Entry DOI: 10.2210/pdb3wsb/pdb
• Related: 3WSA
• Descriptor: Farnesyltransferase, putative, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, N-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, ... (4 entities in total)
• Functional Keywords: isoprenoids, drug discovery, trypanosoma cruzi squalene synthase, sq109, fspp, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Trypanosoma cruzi
• Total number of polymer chains: 4
• Total formula weight: 170363.01

Authors

Shang, N.,Li, Q.,Huang, C.H.,Oldfield, E.,Guo, R.T. (deposition date: 2014-03-05, release date: 2015-04-01, Last modification date: 2023-11-08)

• Primary citation: Shang, N.,Li, Q.,Huang, C.H.,Oldfield, E.,Guo, R.T.; The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole; To be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)