3WSB
The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Farnesyltransferase, putative | polymer | 365 | 41861.8 | 4 | UniProt (Q4CWB4) Pfam (PF00494) In PDB | Trypanosoma cruzi | |
2 | A, B, C, D | S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE | non-polymer | 398.4 | 4 | Chemie (FPS) | |||
3 | A, B, C, D | N-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine | non-polymer | 330.6 | 4 | Chemie (RWZ) | |||
4 | water | water | 18.0 | 433 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 25 - 368 (UniProt: Q4CWB4)
PDB | External Database | Details |
---|---|---|
Met 4 | - | expression tag |
Gly 5 | - | expression tag |
Ser 6 | - | expression tag |
Ser 7 | - | expression tag |
His 8 | - | expression tag |
His 9 | - | expression tag |
His 10 | - | expression tag |
His 11 | - | expression tag |
His 12 | - | expression tag |
His 13 | - | expression tag |
Ser 14 | - | expression tag |
Ser 15 | - | expression tag |
Gly 16 | - | expression tag |
Leu 17 | - | expression tag |
Val 18 | - | expression tag |
Pro 19 | - | expression tag |
Arg 20 | - | expression tag |
Gly 21 | - | expression tag |
Ser 22 | - | expression tag |
His 23 | - | expression tag |
Met 24 | - | expression tag |
Glu 82 | Asp 82 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 167447.2 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2915.8 | |
All* | Total formula weight | 170363.0 |