3WEF

Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate

Summary for 3WEF

Entry DOI	10.2210/pdb3wef/pdb
Related	3VJ8 3VJ9 3VJA 3VJB 3VJC 3VJD 3WEG 3WEH 3WEI 3WEJ 3WEK
Descriptor	Squalene synthase, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE (3 entities in total)
Functional Keywords	farnesyl-diphosphate farnesyltransferase, head-to-head synthases, cholesterol biosynthesis, oxidoreductase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	6
Total formula weight	239880.95
Authors	Liu, C.I.,Jeng, W.Y.,Wang, A.H.J. (deposition date: 2013-07-07, release date: 2014-02-12, Last modification date: 2023-11-08)
Primary citation	Liu, C.I.,Jeng, W.Y.,Chang, W.J.,Shih, M.F.,Ko, T.P.,Wang, A.H.J. Structural insights into the catalytic mechanism of human squalene synthase. Acta Crystallogr.,Sect.D, 70:231-241, 2014 Cited by PubMed: 24531458 DOI: 10.1107/S1399004713026230 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation