3WEF
Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | Squalene synthase | polymer | 343 | 39449.0 | 6 | UniProt (P37268) Pfam (PF00494) In PDB | Homo sapiens (human) | SQS, SS, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase |
| 2 | A, B, C, D, E | S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE | non-polymer | 398.4 | 8 | Chemie (FPS) | |||
| 3 | water | water | 18.0 | 352 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 31 - 370 (UniProt: P37268)
| PDB | External Database | Details |
|---|---|---|
| Gly 28 | - | expression tag |
| Ser 29 | - | expression tag |
| His 30 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 236693.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3187.1 | |
| All* | Total formula weight | 239880.9 |
