7DP5
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![BU of 7dp5 by Molmil](/molmil-images/mine/7dp5) | Crystal structure of mutant V45A Brugia malayi thymidylate synthase complexed with 2'-deoxyuridine monophosphate and methotrexate | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, BETA-MERCAPTOETHANOL, GLYCEROL, ... | 著者 | Keyunratsami, K, Nualnoi, T, Wongkamchai, S, Songsiriritthigul, C, Chen, C.-J, Canyuk, B. | 登録日 | 2020-12-18 | 公開日 | 2021-12-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystallographic investigation and inhibition of Brugia malayi thymidylate synthase by a folate analog To Be Published
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7DP6
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![BU of 7dp6 by Molmil](/molmil-images/mine/7dp6) | Crystal structure of mutant V45T Brugia malayi thymidylate synthase complexed with 2'-deoxyuridine monophosphate | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, BETA-MERCAPTOETHANOL, GLYCEROL, ... | 著者 | Keyunratsami, K, Nualnoi, T, Wongkamchai, S, Songsiriritthigul, C, Chen, C.-J, Canyuk, B. | 登録日 | 2020-12-18 | 公開日 | 2021-12-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystallographic investigation and inhibition of Brugia malayi thymidylate synthase by a folate analog To Be Published
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5X4Y
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![BU of 5x4y by Molmil](/molmil-images/mine/5x4y) | Mutant human thymidylate synthase M190K crystallized in a sulfate-containing condition | 分子名称: | SULFATE ION, Thymidylate synthase | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | 登録日 | 2017-02-14 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
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5X5Q
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![BU of 5x5q by Molmil](/molmil-images/mine/5x5q) | Human thymidylate synthase complexed with dUMP and raltitrexed | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, Thymidylate synthase | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | 登録日 | 2017-02-17 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
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5X67
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![BU of 5x67 by Molmil](/molmil-images/mine/5x67) | Human thymidylate synthase in complex with dUMP and nolatrexed | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-azanyl-6-methyl-5-pyridin-4-ylsulfanyl-3H-quinazolin-4-one, Thymidylate synthase | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | 登録日 | 2017-02-21 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states. J. Biol. Chem., 292, 2017
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5X4X
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![BU of 5x4x by Molmil](/molmil-images/mine/5x4x) | Mutant human thymidylate synthase A191K crystallized in a sulfate-containing condition | 分子名称: | SULFATE ION, Thymidylate synthase | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | 登録日 | 2017-02-14 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
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5X69
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![BU of 5x69 by Molmil](/molmil-images/mine/5x69) | Human thymidylate synthase with a fragment bound in the dimer interface | 分子名称: | 1-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-methanamine, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | 登録日 | 2017-02-21 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
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5X4W
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![BU of 5x4w by Molmil](/molmil-images/mine/5x4w) | Mutant human thymidylate synthase A191K crystallized in a sulfate-free condition | 分子名称: | PHOSPHATE ION, Thymidylate synthase | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | 登録日 | 2017-02-14 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
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5X5D
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![BU of 5x5d by Molmil](/molmil-images/mine/5x5d) | Human thymidylate synthase bound with dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | 登録日 | 2017-02-15 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
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5WRN
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![BU of 5wrn by Molmil](/molmil-images/mine/5wrn) | |
1LCE
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![BU of 1lce by Molmil](/molmil-images/mine/1lce) | LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CH2THF | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5,10-METHYLENE-6-HYDROFOLIC ACID, THYMIDYLATE SYNTHASE | 著者 | Birdsall, D.L, Finer-Moore, J, Stroud, R.M. | 登録日 | 1995-06-22 | 公開日 | 1995-10-15 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
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1LCB
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![BU of 1lcb by Molmil](/molmil-images/mine/1lcb) | |
1LCA
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![BU of 1lca by Molmil](/molmil-images/mine/1lca) | LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CB3717 | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | 著者 | Birdsall, D.L, Finer-Moore, J, Stroud, R.M. | 登録日 | 1995-06-22 | 公開日 | 1995-10-15 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
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1KZJ
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![BU of 1kzj by Molmil](/molmil-images/mine/1kzj) | Crystal Structure of EcTS W80G/dUMP/CB3717 Complex | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase | 著者 | Fritz, T.A, Liu, L, Finer-Moore, J.S, Stroud, R.M. | 登録日 | 2002-02-06 | 公開日 | 2002-07-03 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access. Biochemistry, 41, 2002
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6A9B
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1KZI
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![BU of 1kzi by Molmil](/molmil-images/mine/1kzi) | Crystal Structure of EcTS/dUMP/THF Complex | 分子名称: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, (6S)-5,6,7,8-TETRAHYDROFOLATE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... | 著者 | Fritz, T.A, Liu, L, Finer-Moore, J.S, Stroud, R.M. | 登録日 | 2002-02-06 | 公開日 | 2002-07-03 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access. Biochemistry, 41, 2002
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1NCE
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![BU of 1nce by Molmil](/molmil-images/mine/1nce) | Crystal structure of a ternary complex of E. coli thymidylate synthase D169C with dUMP and the antifolate CB3717 | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase | 著者 | Birdsall, D.L, Finer-Moore, J, Stroud, R.M. | 登録日 | 2002-12-05 | 公開日 | 2002-12-25 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The only active mutant of thymidylate synthase D169, a residue far from the
site of methyl transfer, demonstrates the exquisite nature of enzyme
specificity. Protein Eng., 16, 2003
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6AUJ
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1NJE
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1NJB
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![BU of 1njb by Molmil](/molmil-images/mine/1njb) | THYMIDYLATE SYNTHASE | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | 著者 | Finer-Moore, J, Stroud, R.M. | 登録日 | 1996-01-23 | 公開日 | 1996-10-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Biochemistry, 35, 1996
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1NJA
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![BU of 1nja by Molmil](/molmil-images/mine/1nja) | THYMIDYLATE SYNTHASE, MUTATION, N229C WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP) | 分子名称: | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | 著者 | Finer-Moore, J, Stroud, R.M. | 登録日 | 1996-01-23 | 公開日 | 1996-07-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Biochemistry, 35, 1996
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1NJD
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![BU of 1njd by Molmil](/molmil-images/mine/1njd) | THYMIDYLATE SYNTHASE, MUTATION, N229D WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | 著者 | Finer-Moore, J, Stroud, R.M. | 登録日 | 1996-01-23 | 公開日 | 1996-07-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Biochemistry, 35, 1996
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1NJC
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![BU of 1njc by Molmil](/molmil-images/mine/1njc) | THYMIDYLATE SYNTHASE, MUTATION, N229D WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP) | 分子名称: | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | 著者 | Finer-Moore, J, Stroud, R.M. | 登録日 | 1996-01-23 | 公開日 | 1996-07-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Biochemistry, 35, 1996
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1KCE
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![BU of 1kce by Molmil](/molmil-images/mine/1kce) | E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | 著者 | Sage, C.R, Rutenber, E.E, Stout, T.J, Stroud, R.M. | 登録日 | 1996-10-22 | 公開日 | 1997-04-21 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q. Biochemistry, 35, 1996
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6A9A
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![BU of 6a9a by Molmil](/molmil-images/mine/6a9a) | Ternary complex crystal structure of dCH with dCMP and THF | 分子名称: | (6S)-5,6,7,8-TETRAHYDROFOLATE, 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, Deoxycytidylate 5-hydroxymethyltransferase, ... | 著者 | Park, S.H, Song, H.K. | 登録日 | 2018-07-12 | 公開日 | 2019-01-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A cytosine modification mechanism revealed by the structure of a ternary complex of deoxycytidylate hydroxymethylase from bacteriophage T4 with its cofactor and substrate. Iucrj, 6, 2019
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