5X5Q

Human thymidylate synthase complexed with dUMP and raltitrexed

Summary for 5X5Q

Entry DOI	10.2210/pdb5x5q/pdb
Related	5X4W 5X4X 5X4Y 5X5A 5X5D 5X66 5X67 5X69
Descriptor	Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, ... (4 entities in total)
Functional Keywords	methyltransferase, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P04818
Total number of polymer chains	6
Total formula weight	204124.77
Authors	Chen, D.,Jansson, A.,Larsson, A.,Nordlund, P. (deposition date: 2017-02-17, release date: 2017-06-28, Last modification date: 2023-11-22)
Primary citation	Chen, D.,Jansson, A.,Sim, D.,Larsson, A.,Nordlund, P. Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292:13449-13458, 2017 Cited by PubMed: 28634233 DOI: 10.1074/jbc.M117.787267 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.79 Å)

Structure validation