5X5Q
Human thymidylate synthase complexed with dUMP and raltitrexed
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Thymidylate synthase | polymer | 290 | 33254.1 | 6 | UniProt (P04818) Pfam (PF00303) | Homo sapiens (Human) | TSase |
| 2 | G, I, K, M, O... (A, B, C, D, E...) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 6 | Chemie (UMP) PubChem (57164254) | |||
| 3 | H, J, L, N, P... (A, B, C, D, E...) | TOMUDEX | non-polymer | 458.5 | 6 | Chemie (D16) | |||
| 4 | S, T, U, V, W (A, B, C, D, F) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 26 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| Ser 24 | - | expression tag |
| Met 25 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 199524.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4600.0 | |
| All* | Total formula weight | 204124.8 |
