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5X4W

Mutant human thymidylate synthase A191K crystallized in a sulfate-free condition

Summary for 5X4W
Entry DOI10.2210/pdb5x4w/pdb
Related5X4X 5X4Y 5X5A 5X5D 5X5Q 5X66 5X67 5X69
DescriptorThymidylate synthase, PHOSPHATE ION (3 entities in total)
Functional Keywordsmethyltransferase, transferase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : P04818
Total number of polymer chains1
Total formula weight36098.06
Authors
Chen, D.,Jansson, A.,Larsson, A.,Nordlund, P. (deposition date: 2017-02-14, release date: 2017-06-28, Last modification date: 2023-11-22)
Primary citationChen, D.,Jansson, A.,Sim, D.,Larsson, A.,Nordlund, P.
Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292:13449-13458, 2017
Cited by
PubMed: 28634233
DOI: 10.1074/jbc.M117.787267
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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