1KZJ
Crystal Structure of EcTS W80G/dUMP/CB3717 Complex
Summary for 1KZJ
Entry DOI | 10.2210/pdb1kzj/pdb |
Related | 1KZI |
Descriptor | Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total) |
Functional Keywords | enzyme substrate cofactor analog complex, transferase |
Biological source | Escherichia coli |
Cellular location | Cytoplasm: P0A884 |
Total number of polymer chains | 6 |
Total formula weight | 187296.94 |
Authors | Fritz, T.A.,Liu, L.,Finer-Moore, J.S.,Stroud, R.M. (deposition date: 2002-02-06, release date: 2002-07-03, Last modification date: 2023-08-16) |
Primary citation | Fritz, T.A.,Liu, L.,Finer-Moore, J.S.,Stroud, R.M. Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access. Biochemistry, 41:7021-7029, 2002 Cited by PubMed: 12033935DOI: 10.1021/bi012108c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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