1KZJ

Crystal Structure of EcTS W80G/dUMP/CB3717 Complex

Summary for 1KZJ

• Entry DOI: 10.2210/pdb1kzj/pdb
• Related: 1KZI
• Descriptor: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total)
• Functional Keywords: enzyme substrate cofactor analog complex, transferase
• Biological source: Escherichia coli
• Cellular location: Cytoplasm: P0A884
• Total number of polymer chains: 6
• Total formula weight: 187296.94

Authors

Fritz, T.A.,Liu, L.,Finer-Moore, J.S.,Stroud, R.M. (deposition date: 2002-02-06, release date: 2002-07-03, Last modification date: 2023-08-16)

• Primary citation: Fritz, T.A.,Liu, L.,Finer-Moore, J.S.,Stroud, R.M.; Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.; Biochemistry, 41:7021-7029, 2002; PubMed: 12033935; DOI: 10.1021/bi012108c

Experimental method

X-RAY DIFFRACTION (2.6 Å)