7DP6

Crystal structure of mutant V45T Brugia malayi thymidylate synthase complexed with 2'-deoxyuridine monophosphate

Summary for 7DP6

• Entry DOI: 10.2210/pdb7dp6/pdb
• Descriptor: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, BETA-MERCAPTOETHANOL, ... (5 entities in total)
• Functional Keywords: thymidylate synthase, nucleotide synthase, transferase, methyltransferase
• Biological source: Brugia malayi (Filarial nematode worm)
• Total number of polymer chains: 1
• Total formula weight: 35357.24

Authors

Keyunratsami, K.,Nualnoi, T.,Wongkamchai, S.,Songsiriritthigul, C.,Chen, C.-J.,Canyuk, B. (deposition date: 2020-12-18, release date: 2021-12-22, Last modification date: 2023-11-29)

• Primary citation: Keyunratsami, K.,Nualnoi, T.,Wongkamchai, S.,Songsiriritthigul, C.,Chen, C.-J.,Canyuk, B.; Crystallographic investigation and inhibition of Brugia malayi thymidylate synthase by a folate analog; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)