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PDB: 468 件
5DIU
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The Fk1 domain of FKBP51 in complex with the new synthetic ligand 2-(3-((R)-1-((S)-1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxamido)-3-(3,4-dimethoxyphenyl)propyl)phenoxy)acetic acid
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, {3-[(1R)-1-[({(2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidin-2-yl}carbonyl)amino]-3-(3,4-dimethoxyphenyl)propyl]phenoxy}acetic acid
著者Gaali, S, Feng, X, Sippel, C, Bracher, A, Hausch, F.
登録日2015-09-01
公開日2016-03-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Rapid, Structure-Based Exploration of Pipecolic Acid Amides as Novel Selective Antagonists of the FK506-Binding Protein 51.
J.Med.Chem., 59, 2016
4W9O
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The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1R)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one
分子名称: (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1R)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one, ACETATE ION, Peptidyl-prolyl cis-trans isomerase FKBP5
著者Pomplun, S, Wang, Y, Kirschner, K, Kozany, C, Bracher, A, Hausch, F.
登録日2014-08-27
公開日2014-12-03
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.27 Å)
主引用文献Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs).
Angew.Chem.Int.Ed.Engl., 54, 2015
7R0L
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Structure of the FK1 domain of the FKBP51 G64S variant in complex with SAFit1
分子名称: 2-[3-[(1~{R})-1-[(2~{S})-1-[(2~{S})-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidin-2-yl]carbonyloxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]ethanoic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ...
著者Meyners, C, Hausch, F.
登録日2022-02-02
公開日2022-11-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Binding pocket stabilization by high-throughput screening of yeast display libraries.
Front Mol Biosci, 9, 2022
3KZ7
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C-terminal domain of Murine FKBP25 rapamycin complex
分子名称: FK506-binding protein 3, RAPAMYCIN IMMUNOSUPPRESSANT DRUG
著者Stura, E.A, Galat, A.
登録日2009-12-08
公開日2010-12-15
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Diversified targets of FKBP25 and its complex with rapamycin.
Int.J.Biol.Macromol., 69, 2014
6RCY
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CRYSTAL STRUCTURE OF FK1 DOMAIN OF FKBP52 IN COMPLEX WITH A BIO-INSPIRED HYBRID FLUORESCENT LIGAND
分子名称: (2~{S})-5-carbamimidamido-2-[[(2~{S})-2-[[(2~{S})-1-[5-(dimethylamino)naphthalen-1-yl]sulfonylpiperidin-2-yl]carbonylamino]-4-phenyl-butanoyl]amino]pentanoic acid, Peptidyl-prolyl cis-trans isomerase FKBP4
著者Li de la Sierra-Gallay, I, Byrne, C.
登録日2019-04-12
公開日2020-05-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Bioinspired Hybrid Fluorescent Ligands for the FK1 Domain of FKBP52.
J.Med.Chem., 63, 2020
6B4P
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Crystal Structure of Peptidylprolyl Isomerase from Naegleria fowleri
分子名称: Peptidylprolyl Isomerase
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2017-09-27
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Crystal Structure of Peptidylprolyl Isomerase from Naegleria fowleri
to be published
4W9P
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The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1S)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one
分子名称: (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1S)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one, ACETATE ION, Peptidyl-prolyl cis-trans isomerase FKBP5
著者Pomplun, S, Wang, Y, Kirschner, K, Kozany, C, Bracher, A, Hausch, F.
登録日2014-08-27
公開日2014-12-03
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs).
Angew.Chem.Int.Ed.Engl., 54, 2015
4W9Q
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The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-5-ethyl-3,10-diazabicyclo[4.3.1]decan-2-one
分子名称: (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-5-ethyl-3,10-diazabicyclo[4.3.1]decan-2-one, Peptidyl-prolyl cis-trans isomerase FKBP5
著者Pomplun, S, Wang, Y, Kirschner, K, Kozany, C, Bracher, A, Hausch, F.
登録日2014-08-27
公開日2014-12-03
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.08 Å)
主引用文献Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs).
Angew.Chem.Int.Ed.Engl., 54, 2015
2Y78
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Crystal structure of BPSS1823, a Mip-like chaperone from Burkholderia pseudomallei
分子名称: CHLORIDE ION, GLYCEROL, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE, ...
著者Norville, I.H, O'Shea, K, Sarkar-Tyson, M, Harmer, N.J.
登録日2011-01-28
公開日2011-05-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (0.91 Å)
主引用文献The Structure of a Burkholderia Pseudomallei Immunophilin-Inhibitor Complex Reveals New Approaches to Antimicrobial Development
Biochem.J., 437, 2011
5MGX
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The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP8, yeast HSP90 C-terminus
著者Roe, S.M, Blundell, K.L, Prodromou, C.
登録日2016-11-22
公開日2017-03-22
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90.
PLoS ONE, 12, 2017
3B7X
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Crystal structure of human FK506-Binding Protein 6
分子名称: FK506-binding protein 6
著者Walker, J.R, Davis, T, Butler-Cole, C, Paramanathan, R, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2007-10-31
公開日2007-11-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Human FK506-Binding Protein 6.
To be Published
5ZR0
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Solution structure of peptidyl-prolyl cis/trans isomerase domain of Trigger Factor in complex with MBP
分子名称: Maltose-binding periplasmic protein,Trigger factor
著者Kawagoe, S, Nakagawa, H, Kumeta, H, Ishimori, K, Saio, T.
登録日2018-04-21
公開日2018-08-22
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural insight into prolinecis/transisomerization of unfolded proteins catalyzed by the trigger factor chaperone.
J. Biol. Chem., 293, 2018
4ODL
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Structure of SlyD from Thermus thermophilus in complex with S2 peptide
分子名称: 30S ribosomal protein S2, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase SlyD
著者Quistgaard, E.M, Low, C, Nordlund, P.
登録日2014-01-10
公開日2015-01-14
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.916 Å)
主引用文献Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.
BMC Biol., 14, 2016
4ODQ
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Structure of SlyD delta-IF from Thermus thermophilus in complex with S3 peptide
分子名称: 30S ribosomal protein S3, CALCIUM ION, CHLORIDE ION, ...
著者Quistgaard, E.M, Low, C, Nordlund, P.
登録日2014-01-10
公開日2015-01-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.
BMC Biol., 14, 2016
4ODP
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Structure of SlyD delta-IF from Thermus thermophilus in complex with S2-W23A peptide
分子名称: 30S ribosomal protein S2, CALCIUM ION, CHLORIDE ION, ...
著者Quistgaard, E.M, Low, C, Nordlund, P.
登録日2014-01-10
公開日2015-01-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.747 Å)
主引用文献Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.
BMC Biol., 14, 2016
6OQA
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Crystal structure of CEP250 bound to FKBP12 in the presence of FK506-like novel natural product
分子名称: (3R,4E,7E,10R,11S,12R,13S,16R,17R,24aS)-11,17-dihydroxy-10,12,16-trimethyl-3-[(2R)-1-phenylbutan-2-yl]-6,9,10,11,12,13,14,15,16,17,22,23,24,24a-tetradecahydro-3H-13,17-epoxypyrido[2,1-c][1,4]oxazacyclohenicosine-1,18,19(21H)-trione, 1,2-ETHANEDIOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ...
著者Lee, S.-J, Shigdel, U.K, Townson, S.A, Verdine, G.L.
登録日2019-04-26
公開日2020-04-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface.
Proc.Natl.Acad.Sci.USA, 117, 2020
1YAT
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IMPROVED CALCINEURIN INHIBITION BY YEAST FKBP12-DRUG COMPLEXES. CRYSTALLOGRAPHIC AND FUNCTIONAL ANALYSIS
分子名称: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, FK506 BINDING PROTEIN
著者Rotonda, J, Becker, J.W.
登録日1993-01-06
公開日1993-10-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis.
J.Biol.Chem., 268, 1993
6PV6
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Functional Pathways of Biomolecules Retrieved from Single-particle Snapshots
分子名称: CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ...
著者Dashti, A, des Georges, A, Frank, J, Ourmazd, A.
登録日2019-07-19
公開日2020-08-12
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Retrieving functional pathways of biomolecules from single-particle snapshots.
Nat Commun, 11, 2020
1Y0O
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crystal structure of reduced AtFKBP13
分子名称: FKBP-type peptidyl-prolyl cis-trans isomerase 3
著者Gayathri, G, Swaminathan, K.
登録日2004-11-15
公開日2005-11-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Crystal structure of reduced AtFKBP13
to be published
2AWG
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Structure of the PPIase domain of the Human FK506-binding protein 8
分子名称: 38 kDa FK-506 binding protein
著者Walker, J.R, Davis, T, Newman, E.M, Finerty, P, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2005-09-01
公開日2005-09-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of the human FK-506 binding protein 8
To be Published
4TW6
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The Fk1 domain of FKBP51 in complex with iFit1
分子名称: (3-{(1R)-3-(3,4-dimethoxyphenyl)-1-[({(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)pent-4-enoyl]piperidin-2-yl}carbonyl)oxy]propyl}phenoxy)acetic acid, GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP5, ...
著者Gaali, S, Kirschner, A, Cuboni, S, Hartmann, J, Kozany, C, Balsevich, G, Namendorf, C, Fernandez-Vizarra, P, Almeida, O.F.X, Ruehter, G, Uhr, M, Schmidt, M.V, Touma, C, Bracher, A, Hausch, F.
登録日2014-06-30
公開日2014-11-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Selective inhibitors of the FK506-binding protein 51 by induced fit.
Nat.Chem.Biol., 11, 2015
4TW8
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The Fk1-Fk2 domains of FKBP52 in complex with iFit-FL
分子名称: 2-(5-{[({3-[(1R)-1-[({(2S)-1-[(2S)-2-[(1S)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidin-2-yl}carbonyl)oxy]-3-(3,4-dimethoxyphenyl)propyl]phenoxy}acetyl)amino]methyl}-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid, Peptidyl-prolyl cis-trans isomerase FKBP4
著者Gaali, S, Kirschner, A, Cuboni, S, Hartmann, J, Kozany, C, Balsevich, G, Namendorf, C, Fernandez-Vizarra, P, Almeida, O.F.X, Ruehter, G, Uhr, M, Schmidt, M.V, Touma, C, Bracher, A, Hausch, F.
登録日2014-06-30
公開日2014-11-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.003 Å)
主引用文献Selective inhibitors of the FK506-binding protein 51 by induced fit.
Nat.Chem.Biol., 11, 2015
4TW7
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The Fk1 domain of FKBP51 in complex with iFit4
分子名称: (1R)-3-(3,4-dimethoxyphenyl)-1-{3-[2-(morpholin-4-yl)ethoxy]phenyl}propyl (2S)-1-[(2S)-2-[(1S)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5
著者Gaali, S, Kirschner, A, Cuboni, S, Hartmann, J, Kozany, C, Balsevich, G, Namendorf, C, Fernandez-Vizarra, P, Almeida, O.F.X, Ruehter, G, Uhr, M, Schmidt, M.V, Touma, C, Bracher, A, Hausch, F.
登録日2014-06-30
公開日2014-11-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Selective inhibitors of the FK506-binding protein 51 by induced fit.
Nat.Chem.Biol., 11, 2015
4TX0
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The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-(2-methoxyethoxy)-3-(2-methoxyethyl)-3,10-diazabicyclo[4.3.1]decan-2-one
分子名称: (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-(2-methoxyethoxy)-3-(2-methoxyethyl)-3,10-diazabicyclo[4.3.1]decan-2-one, Peptidyl-prolyl cis-trans isomerase FKBP5
著者Bischoff, M, Sippel, C, Bracher, A, Hausch, F.
登録日2014-07-02
公開日2014-10-15
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.03 Å)
主引用文献Stereoselective Construction of the 5-Hydroxy Diazabicyclo[4.3.1]decane-2-one Scaffold, a Privileged Motif for FK506-Binding Proteins.
Org.Lett., 16, 2014
6YF1
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FKBP12 in complex with the BMP potentiator compound 8 at 1.12A resolution
分子名称: (1aR,3R,5S,6R,7S,9R,10R,17aS,20S,21R,22S,25R,25aR)-25-Ethyl-10,22-dihydroxy-20-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-5,7-dimethoxy-1a,3,9,21-tetramethyloctadecahydro-2H-6,10-epoxyoxireno[p]pyrido[2,1-c][1,4]oxazacyclotricosine-11,12,18,24(1aH,14H)-tetrone, Peptidyl-prolyl cis-trans isomerase FKBP1A
著者Kallen, J.
登録日2020-03-25
公開日2021-03-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.12 Å)
主引用文献Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury.
Cell Chem Biol, 28, 2021

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